First ‘milestone’ vaccine offers 90% protection

‘The first effective coronavirus vaccine can prevent more than 90% of people from getting Covid-19, a preliminary analysis shows. The developers - Pfizer and BioNTech - described it as a "great day for science and humanity". Their vaccine has been tested on 43,500 people in six countries and no safety concerns have been raised. The companies plan to apply for emergency approval to use the vaccine by the end of the month.’

Read here (BBC, Nov 9, 2020) 

‘Mutant coronavirus’ seen before on mink farms, say scientists

‘The coronavirus mutation causing concern in Denmark has arisen before in mink, scientists have revealed. The mutated virus has been detected retrospectively in mink at a farm in the Netherlands, but it did not spread to humans, said a leading Dutch expert...

‘The genetic data from Denmark was released on an international database a few days ago, with some scientists questioning why it had not been released sooner. "I think that it is most disappointing that the data have only just reached the light of day," said Prof James Wood, head of the department of veterinary medicine at the University of Cambridge, UK...

‘Six countries have reported coronavirus outbreaks at mink farms: the Netherlands, Denmark, Spain, Sweden, Italy and the US.’

Read here (BBC, Nov 9, 2020)

Antibodies ‘fall rapidly after infection’

‘Levels of protective antibodies in people wane "quite rapidly" after coronavirus infection, say researchers. Antibodies are a key part of our immune defences and stop the virus from getting inside the body's cells. The Imperial College London team found the number of people testing positive for antibodies has fallen by 26% between June and September. They say immunity appears to be fading and there is a risk of catching the virus multiple times. The news comes as figures from the Office for National Statistics show that the number of Covid-19 deaths in the UK rose by 60% in the week of 16 October.’

Read here (BBC, Oct 28, 2020)

Read here NEJM paper on Iceland which throws into question this

Back to intensive care, where I notice one major change

‘When I first reported from a Covid intensive care unit in April, I was left haunted by what I'd seen. All but one patient had been on a ventilator, in a medically induced coma. It was eerily quiet, just the rhythmical sound of machines pumping air into lungs.

‘The medical teams were at a loss to know how best to treat a savage condition which was ravaging victims' lungs and other organs. Lives hung in the balance, often for weeks on end. In early April, two out of three ventilated patients did not survive.

‘Today, in this intensive care unit (ICU) at the Royal Victoria Infirmary, Newcastle upon Tyne, only one of the five patients is on a ventilator. The others are sitting up, engaging with the nurses, reading or watching TV.’

Read here (BBC, Oct 27, 2020)

Coronavirus: How the world of work may change forever

‘More than seven months have passed since the World Health Organization declared Covid-19 a pandemic. Hundreds of millions of people have lived through lockdowns. Many have made the abrupt shift to working from home; millions have lost jobs. The future looks uncertain. We don't know when, or if, our societies might return to normal – or what kind of scars the pandemic will leave.

‘Amid the upheaval, BBC Worklife spoke to dozens of experts, leaders and professionals across the globe to ask: what are the greatest unknowns we face? How will we work, live and thrive in the post-pandemic future? How is Covid-19 reshaping our world – potentially, forever?

‘We’ll roll out these important views from some of the top minds in business, public health and many other fields in several articles over the next few weeks. We'll hear from people including Melinda Gates on gender equality, Zoom founder Eric Yuan on the future of video calls, Lonely Planet founder Tony Wheeler on what’s next in travel and Unesco chief Audrey Azoulay on the ethics of artificial intelligence.’

Read here (BBC, as at Oct 26, 2020)

Why is coronavirus so deadly?

1. Master of deception: ‘In the early stages of an infection the virus is able to deceive the body. Coronavirus can be running rampant in our lungs and airways and yet our immune system thinks everything is a-ok.’
2. It behaves like a 'hit and run' killer: ‘The amount of virus in our body begins to peak the day before we begin to get sick. But it takes at least a week before Covid progresses to the point where people need hospital treatment.’ 
3. It's new, so our bodies are unprepared: ‘This lack of prior-protection is comparable to when Europeans took smallpox with them to the New World, with deadly consequences.’
4. It does peculiar and unexpected things to the body: ‘Covid starts off as a lung disease (even there it does strange and unusual things) and can affect the whole body.’ Like “corrupting” lung cells, clotting blood and causing runaway inflammation.
5. And we're fatter than we should be: ‘Covid is worse if you are obese, as a generous waistline increases the risk of needing intensive care, or death.’

Read here (BBC, Oct 23, 2020)

Covid reinfection: Man gets Covid twice and second hit 'more severe'

‘A man in the United States has caught Covid twice, with the second infection becoming far more dangerous than the first, doctors report. The 25-year-old needed hospital treatment after his lungs could not get enough oxygen into his body. Reinfections remain rare and he has now recovered. But the study in the Lancet Infectious Diseases raises questions about how much immunity can be built up to the virus.’

Read here (BBC, Oct 13, 2020)

WHO head calls herd immunity approach ‘immoral’

‘The head of the World Health Organization has ruled out a herd immunity response to the pandemic. Herd immunity occurs when a large portion of a community becomes immune to a disease through vaccinations or through the mass spread of a disease. Some have argued that coronavirus should be allowed to spread naturally in the absence of a vaccine. But WHO chief Tedros Ghebreyesus said such an approach was "scientifically and ethically problematic".’

Read here (BBC, Oct 13, 2020)

India's new paper Covid-19 test could be a ‘game changer’

‘A team of scientists in India has developed an inexpensive paper-based test for coronavirus that could give fast results similar to a pregnancy test. The test, named after a famous Indian fictional detective, is based on a gene-editing technology called Crispr. Scientists estimate that the kit - called Feluda - would return results in under an hour and cost 500 rupees (about $6.75; £5.25). Feluda will be made by a leading Indian conglomerate, Tata, and could be the world's first paper-based Covid-19 test available in the market.

‘Researchers at the Delhi-based Institute of Genomics and Integrative Biology (IGIB), where Feluda was developed, as well as private labs, tried out the test on samples from about 2,000 patients, including ones who had already tested positive for the coronavirus. They found that the new test had 96% sensitivity and 98% specificity...’

Read here (BBC, Oct 4, 2020)

What is the risk to Donald Trump's health?

‘Donald Trump has clear risk factors - including his age, weight and being male - that all raise the chances of a severe coronavirus infection. He is 74 and has a Body Mass Index (BMI) over 30, which is the clinical definition of obesity. So now he has tested positive for the virus, what does it mean?’

Read here (BBC, Oct 2, 2020)

Covid-19: UK could face 50,000 cases a day by October without action - Vallance

‘The UK could see 50,000 new coronavirus cases a day by mid-October without further action, the government's chief scientific adviser has warned. Sir Patrick Vallance said that "would be expected to lead to about 200 deaths per day" a month after that. It comes as the PM prepares to chair a Cobra emergency committee meeting on Tuesday morning, then make a statement in the House of Commons.’

Read here (BBC, Sept 21, 2020)

Could bartering become the new buying in a changed world?

‘The increase in bartering is nowhere better exemplified than in Fiji, which inspired Dunne’s London group. The country has a long tradition of barter, known as ‘veisa’. It’s only grown amid Covid-19, and Fijians have harnessed modern technology to connect even more people...

‘Along with goods, some people have been trading another precious commodity that they may have had more of recently – time. ‘Time banking’, which started in Japan in the 1970s, and in the US in 1992, is seeing a jump in popularity. Members of a time bank spend one hour helping another member, and can receive one hour of help in return. People offer and receive things such as piano lessons, painting services or language teaching.’

Read here (BBC, August 27, 2020) 

False and misleading claims about vaccines debunked

‘In the week that Oxford University announced promising results from its coronavirus vaccine trial, we're looking at claims on social media about vaccines and misleading statements about their safety.

‘The anti-vaccination movement has gained traction online in recent years, and campaigners opposed to vaccination have moved their focus to making claims relating to the coronavirus.’

Read here (BBC, July 26, 2020)

The people with hidden immunity against Covid-19

‘While the latest research suggests that antibodies against Covid-19 could be lost in just three months, a new hope has appeared on the horizon: the enigmatic T cell... T cells are a kind of immune cell, whose main purpose is to identify and kill invading pathogens or infected cells. It does this using proteins on its surface, which can bind to proteins on the surface of these imposters... Several studies have shown that people infected with Covid-19 tend to have T cells that can target the virus, regardless of whether they have experienced symptoms...

‘Most bizarrely of all, when researchers tested blood samples taken years before the pandemic started, they found T cells which were specifically tailored to detect proteins on the surface of Covid-19. This suggests that some people already had a pre-existing degree of resistance against the virus before it ever infected a human. And it appears to be surprisingly prevalent: 40-60% of unexposed individuals had these cells.’

Read here (BBC, July 20, 2020)

Protein treatment trial ‘a breakthrough’

‘The preliminary results of a clinical trial suggest a new treatment for Covid-19 dramatically reduces the number of patients needing intensive care, according to the UK company that developed it. The treatment from Southampton-based biotech Synairgen uses a protein called interferon beta which the body produces when it gets a viral infection... The initial findings suggest the treatment cut the odds of a Covid-19 patient in hospital developing severe disease - such as requiring ventilation - by 79%.’

Read here (BBC, July 20, 2020

UN makes record $10.3bn appeal for pandemic fight: Up to 265m people could face starvation by end-2020

‘The United Nations is making an appeal for $10.3 billion (£8.2 billion) to help fight the coronavirus pandemic, its largest ever fundraising call. The UN says up to 265 million people could face starvation by the end of the year because of the impact of Covid-19. The money will be for used for low income and fragile countries.’

Read here (BBC, July 17, 2020)

The coronavirus may not have originated in China, says Oxford professor

‘The coronavirus may have been lying dormant across the world until emerging under favourable environmental conditions, rather than originating in China, an expert has claimed.

‘Dr Tom Jefferson, from the Centre for Evidence-Based Medicine (CEBM) at Oxford University, has pointed to a string of recent discoveries of the virus’s presence around the world before it emerged in Asia as growing evidence of its true origin as a global organism that was waiting for favourable conditions to finally emerge.

‘Traces of COVID-19 have been found in sewage samples from Spain, Italy and Brazil which pre-date its discovery in China. A preprint study, which has not been peer reviewed, claims to have found the presence of SARS-CoV-2 genomes in a Barcelona sewage sample from 12 March 2019.’

Read here (BBC Science Focus, July 6, 2020)

The long-term effects of Covid-19 infection

‘Some scientists suspect that Covid-19 causes respiratory failure and death not through damage to the lungs, but the brain – and other symptoms include headaches, strokes and seizures... For Julie Helms, it started with a handful of patients admitted to her intensive care unit at Strasbourg University Hospital in northeast France in early March 2020. Within days, every single patient in the ICU had Covid-19 – and it was not just their breathing difficulties that alarmed her. “They were extremely agitated, and many had neurological problems – mainly confusion and delirium,” she says. “We are used to having some patients in the ICU who are agitated and require sedation, but this was completely abnormal. It has been very scary, especially because many of the people we treated were very young – many in their 30s and 40s, even an 18-year-old.”

‘Helms and her colleagues published a small study in the New England Journal of Medicine documenting the neurological symptoms in their Covid-19 patients, ranging from cognitive difficulties to confusion. All are signs of “encephalopathy” (the general term for damage to the brain) – a trend that researchers in Wuhan had noticed in coronavirus patients there in February.’

Read here (BBC, June 23, 2020)

New Covid-19 tracing tool appears on smartphones

‘A Covid-19 tracing software tool has appeared in the settings of both Android phones and iPhones as part of an update of their operating systems. The "exposure notification" tool is switched off by default, and is not a tracing app itself. It enables an app to run in the background while still using Bluetooth. This lets the app measure the distance between two handsets - and then alert the phone owner if someone near them later tests positive for Covid-19.’

Read here (BBC, June 20, 2020)

What is the true death toll of the pandemic?

‘At least another 130,000 people worldwide have died during the coronavirus pandemic on top of 440,000 officially recorded deaths from the virus, according to BBC research. A review of preliminary mortality data from 27 countries shows that in many places the number of overall deaths during the pandemic has been higher than normal, even when accounting for the virus.’

Read here (BBC, June 19, 2020)