Science alone can’t heal a sick society

‘Science is a social process, and we all live amid the social soup of personalities, parties and power. The political dysfunction that holds America hostage also holds science hostage. Dr. Virchow wrote that “mass disease means that society is out of joint.” Society’s being out of joint means that epidemiological research is out of joint, because it exists inside the same society. This is not a new problem, but the dominant “follow the science” mantra misses the fact that the same social pathology that exacerbates the pandemic also debilitates our scientific response to it.

‘To restore faith in science, there must be faith in social institutions more broadly, and this requires a political reckoning. Of course one can cite many specific challenges for scientists: The wheels are coming off the peer review system, university research is plagued by commercialization pressures, and so on. But all of these are the symptoms, not the underlying disease. The real problem is simply that sick societies have sick institutions. Science is not some cloistered preserve in the clouds, but is buried in the muck with everything else. This is why, just eight days after his investigation in Upper Silesia, Dr. Virchow went to the barricades in Berlin to fight for the revolution.‘

Read here (New York Times, Sept 10, 2021)

Kati Kariko helped shield the world from the coronavirus

‘Collaborating with devoted colleagues, Dr. Kariko laid the groundwork for the mRNA vaccines turning the tide of the pandemic...

‘Now Katalin Kariko, 66, known to colleagues as Kati, has emerged as one of the heroes of Covid-19 vaccine development. Her work, with her close collaborator, Dr. Drew Weissman of the University of Pennsylvania, laid the foundation for the stunningly successful vaccines made by Pfizer-BioNTech and Moderna.

‘For her entire career, Dr. Kariko has focused on messenger RNA, or mRNA — the genetic script that carries DNA instructions to each cell’s protein-making machinery. She was convinced mRNA could be used to instruct cells to make their own medicines, including vaccines.

‘But for many years her career at the University of Pennsylvania was fragile. She migrated from lab to lab, relying on one senior scientist after another to take her in. She never made more than $60,000 a year.’

Read here (New York Times, Apr 7, 2021)

How Covid can change your personality

‘I don’t know about you, but I’ve found the latest stage of the pandemic hard in its own distinct way. The cumulative effect of a year of repetition, isolation and stress has induced a lassitude — a settling into the familiar, with feelings of vulnerability. The shock of a year ago has been replaced by a sluggish just-getting-to-the-end.

‘I’ve got the same scattered memory issues many others in this Groundhog Day life describe: walking into a room and wondering why I went there; spending impressive amounts of time looking for my earbuds; forgetting the names of people and places outside my Covid bubble.

‘My extroversion muscles have atrophied while my introversion muscles are bulging. If you tracked me on a personality chart, I suppose “liveliness” would be down and “reserved” would be up; “carefree” down and “anxious” up.’

Read here (New York Times, Apr 1, 2021) 

How Covid can change your personality

‘I’m trying to describe a year in which we’ve all been physically hunkered down but socially and morally less connected. This has induced, at least in me, a greater fragility but also a great sense of flexibility, and a greater potential for change.

‘I’ve found I’ve burned out on my screens, burned out about the politicization of everything, and have rediscovered my love for the New York Mets. People who have endured an era of vulnerability emerge with great strength. I’m also convinced that the second half of this year is going to be more fantastic than we can imagine right now. We are going to become hyper-appreciators, savoring every small pleasure, living in a thousand delicious moments, getting together with friends and strangers and seeing them with the joy of new and grateful eyes.’

Read here (New York Times, Apr 1, 2021)

NY Times lies to say WHO investigators dissatisfied with Chinese cooperation

This story carries the rebuttals on Twitter by two WHO expert-team members, Peter Daszak, British zoologist, and Thea Kølsen Fischer, a Danish epidemiologist. It also provides a background to the story, quoting various findings elsewhere in the world. The earlier studies suggest that the Covid-19 virus could have circulated in Europe before it surfaced in Wuhan. 

Read here (Scoop NZ, Feb 15, 2021)

WHO experts slam NYT for twisting, misquoting their words on virus origins probe

‘WHO experts who recently visited Wuhan slammed the New York Times for twisting their words and casting shadows over the efforts to uncover the origins of the virus, after the newspaper accused China of refusing to hand over sensitive data to WHO experts.

‘The report by New York Times titled “On WHO Trip, China Refused to Hand Over Important Data” accuses China of failing to share important data that may help in identifying the origins of the virus and prevent future outbreaks.

 ‘After the report was published, two WHO experts [Peter Daszak, British zoologist and Thea Kølsen Fischer, a Danish epidemiologist] slammed New York Times for misquoting them in the report to fit its own narrative, with the report casting a shadow over the scientific work of seeking for virus origin.’

Read here (Global Times, Feb 14, 2021)

On WHO trip, China refused to hand over important data

‘Chinese scientists refused to share raw data that might bring the world closer to understanding the origins of the coronavirus pandemic, independent investigators for the World Health Organization said Friday.

‘The investigators, who recently returned from a fact-finding trip to the Chinese city of Wuhan, said disagreements over patient records and other issues were so tense that they sometimes erupted into shouts among the typically mild-mannered scientists on both sides.

‘China’s continued resistance to revealing information about the early days of the coronavirus outbreak, the scientists say, makes it difficult for them to uncover important clues that could help stop future outbreaks of such dangerous diseases.

“If you are data focused, and if you are a professional,” said Thea Kølsen Fischer, a Danish epidemiologist on the team, then obtaining data is “like for a clinical doctor looking at the patient and seeing them by your own eyes.”

‘For 27 days in January and February, the team of 14 experts for the WHO led the mission to trace the origins of the pandemic. Several say their Chinese counterparts were frustrated by the team’s persistent questioning and demands for data.’

Read here (New York Times via Economic Times, India, Feb 13, 2021)

It’s time to trust China’s and Russia’s vaccines

‘The fact is that no Covid-19 vaccine has been developed or released as transparently as it should have been. And while China and Russia may have botched their rollouts more than some Western companies, that doesn’t necessarily mean their vaccines are shoddy. The mounting evidence showing that the Chinese and Russian vaccines are reliable should be taken seriously, and fast, especially considering supply issues throughout the world...

‘What’s more, most big pharmaceutical companies in the West have resisted licensing their vaccines to non-Western manufacturers, and several wealthy countries are blocking a proposal by India and South Africa that the World Trade Organization temporarily suspend some intellectual property protections for Covid-19-related vaccines and treatments.

‘On the other hand, according to our latest analysis of data provided by the analytics firm Airfinity, Sinovac has already signed deals to export this year more than 350 million doses of its vaccine to 12 countries; Sinopharm, around 194 million doses to 11 countries; Sputnik V, about 400 million doses to 17 countries. All three manufacturers have stated publicly that they will have the capacity to produce up to 1 billion doses each in 2021. And all three have licensed their vaccines to local manufacturers in several countries.’

Read here (New York Times, Feb 5, 2021)

The ‘vaccine passport’: Answers to your questions

‘In the near future, travel may require digital documentation showing that passengers have been vaccinated or tested for the coronavirus. Answers to your questions:

• What is a vaccine pass or passport?
• Why would I need a vaccine pass or passport?
• Has this been done before?
• Do vaccine passports have to be digital?
• What are the objections to vaccine passports?
• What are the challenges to creating these digital passes?

Read here (New York Times, Feb 4, 2021)

Pregnant women get conflicting advice on Covid-19 vaccines

‘Pregnant women looking for guidance on Covid-19 vaccines are facing the kind of confusion that has dogged the pandemic from the start: The world’s leading public health organizations — the U.S. Centers for Disease Control and Prevention, and the World Health Organization — are offering contradictory advice. Neither organization explicitly forbids or encourages immunizing pregnant women. But weighing the same limited studies, they provide different recommendations.’

Read here (New York Times, Feb 2, 2021)

How Gamaleya’s vaccine (Sputnik V) works

‘The Gamaleya Research Institute, part of Russia’s Ministry of Health, developed a coronavirus vaccine known as Sputnik V or Gam-Covid-Vac. Gamaleya announced in December that the vaccine had an efficacy of 91.4 percent. Russia is using it in a mass vaccination campaign, and it is now being distributed in Argentina, Belarus and other countries.’ This story tells you in graphic form how it works...

Read here (New York Times, Jan 8, 2021)

A second Chinese coronavirus vaccine is said to be effective

‘Brazilian officials said Thursday that a coronavirus vaccine made by a Chinese company was effective, bolstering the chances of approval for a second Chinese inoculation that could be rolled out in much of the developing world. Officials in the state of São Paulo, where a prominent medical research institute carried out a large study of the vaccine made by the Beijing-based Sinovac, said the inoculation had an efficacy rate of 78 percent.

‘The vaccine prevented all participants from developing serious and mild complications from the virus, officials said, calling it a highly effective preventive tool. Sinovac Biotech has sold more than 300 million doses to the developing world, filling a gap left by Western countries.’

Read here (New York Times, Jan 7, 2021)

Blunders eroded US confidence in early vaccine front-runner

‘On the afternoon of Sept. 8, AstraZeneca officials had a conference call with the Food and Drug Administration. The discussion covered important ground: What would AstraZeneca need to do to win the F.D.A.’s blessing for the coronavirus vaccine it was developing with the University of Oxford?

‘But the AstraZeneca representatives neglected to mention a crucial development: Two days earlier, the company had quietly halted trials of its vaccine around the world, including a late-stage study in the United States. It acted after a participant in Britain fell ill.

‘A few hours after the conference call, the story broke about the halted trials. That was how key F.D.A. officials heard the news, according to people with knowledge of the discussions.’

Read here (New York Times, Dec 8, 2020)

Covid survivors with long-term symptoms need urgent attention, experts say

‘There is an urgent need to address long-term symptoms of the coronavirus, leading public health officials said this week, warning that hundreds of thousands of Americans and millions of people worldwide might experience lingering problems that could impede their ability to work and function normally.

‘In a two-day meeting Thursday and Friday, the federal government’s first workshop dedicated to long-term Covid-19, public health officials, medical researchers and patients said the condition needed to be recognized as a syndrome, given a name and taken seriously by doctors. “This is a phenomenon that is really quite real and quite extensive,” Dr. Anthony S. Fauci, the nation’s top infectious diseases expert, said at the conference on Thursday.’

Read here (New York Times, Dec 4, 2020)

US states that imposed few restrictions now have the worst outbreaks

‘Coronavirus cases are rising in almost every U.S. state. But the surge is worst now in places where leaders neglected to keep up forceful virus containment efforts or failed to implement basic measures like mask mandates in the first place, according to a New York Times analysis of data from the University of Oxford. Using an index that tracks policy responses to the pandemic, these charts show the number of new virus cases and hospitalizations in each state relative to the state’s recent containment measures.’

Read here (New York Times, Nov 18, 2020)

Stanford study suggests indoor dining presents huge Covid-19 infection risk

‘According to the New York Times, the study followed the movement of 98 million people to and from indoor public spaces, then calculated traffic to each spot visited as well as how long people stay and each venue’s square footage. Using the area’s infection rate, they then used “standard infectious disease assumptions” to determine how the illness spread across cities.

‘Stanford computer scientist Jure Leskovec, the senior author of the report, tells the Times that “restaurants were by far the riskiest places” for new infections, “about four times riskier than gyms and coffee shops, followed by hotels,” he says. It’s news that jibes with another recent study from the Centers for Disease Control and Prevention (CDC), which said in September that a study of adults across 11 U.S. cities who tested positive for the novel coronavirus were twice as likely to have dined out within the last two weeks than those who tested negative.’

Read here (Eater San Francisco, Nov 11, 2020)

What fans of ‘herd immunity’ don’t tell you

‘First, it makes no mention of harm to infected people in low-risk groups, yet many people recover very slowly. More serious, a significant number, including those with no symptoms, suffer damage to their heart and lungs. One recent study of 100 recovered adults found that 78 of them showed signs of heart damage. We have no idea whether this damage will cut years from their lives or affect their quality of life...

‘Second, it says little about how to protect the vulnerable. One can keep a child from visiting a grandparent in another city easily enough, but what happens when the child and grandparent live in the same household? And how do you protect a 25-year-old diabetic, or cancer survivor, or obese person, or anyone else with a comorbidity who needs to go to work every day?...

‘Third, the declaration omits mention of how many people the policy would kill. It’s a lot...If these restrictions are simply eased — as opposed to eliminating them entirely, which would occur if herd immunity were pursued — deaths could rise to as many as 571,527. That’s just by Feb. 1. The model predicts daily deaths will still be increasing then.

‘Will we have achieved herd immunity then? No.’

Read here (New York Times, Oct 19, 2020)

China got better. We got sicker. Thanks, Trump

‘Public health expert Dr. David Katz argued in a New York Times op-ed and in an interview with me back in March that we needed a national plan that balanced saving the most lives and the most livelihoods at the same time. If we just focused on saving every life, we would create millions of deaths of despair from lost jobs, savings and businesses. If we just focused on saving every job, we would cruelly condemn to death fellow Americans who deserved no such fate.

‘Katz argued for a strategy of “total harm minimization” that would have protected the elderly and most vulnerable, while gradually feeding back into the work force the young and healthy most likely to experience the coronavirus either asymptomatically or mildly — and let them keep the economy humming and build up some natural herd immunity as we awaited a vaccine.

‘Unfortunately, we could never have a sane, sober discussion about such a strategy. From the right, said Katz, we got “contemptuous disdain” for doing even the simplest things, like wearing a mask and social distancing. The left was much more responsible, he added, but not immune from treating any discussion of economic trade-offs in a pandemic as immoral and “treating any policy allowing for any death as an act of sociopathy.”

Read here (New York Times via Salt Lake Tribune, Oct 15, 2020)

Europe, which thought it had the virus tamed, faces a resurgence: Averaged over 100,000 new cases per day last week

‘From France to Russia, from Britain to the Czech Republic, European leaders are confronting a surge in coronavirus cases that is rapidly filling hospital beds, driving up death tolls and raising the grim prospect of further lockdowns in countries already traumatized by the pandemic. The continent, which once compared favorably to the United States in its handling of the pandemic, is being engulfed by a second wave of infection. With an average of more than 100,000 new infections per day over the past week, Europe now accounts for about one-third of new cases reported worldwide.’

Read here (New York Times, Oct 14, 2020)

Uncertainty is hope

‘As her husband continued to fail, with his odds of survival lessening and his end drawing near, she realized, “When things are overwhelmingly hard and scary, and the prognosis is generally not good, sometimes hope lies in the unknown,” she told me. It took me a few minutes to grasp what she meant as she continued, “Uncertainty and unpredictability — suddenly and surprisingly — are where there’s an opening for hope.” She summed up her hard-earned wisdom this way: “Uncertainty is hope.” Uncertainty can be hope. I might add that uncertainty can also be possibility, which I needed all those years ago, as much as we do right now.’

Read here (New York Times, Oct 8, 2020)