Showing posts with label origin. Show all posts
Showing posts with label origin. Show all posts

Saturday 20 November 2021

New study supports natural origins of Covid-19, sources close to WHO team say

‘The virus that causes COVID-19 likely jumped from animals to humans at the Huanan wet market in Wuhan, China, according to a landmark new analysis by evolutionary biologist Michael Worobey published in the journal Science. Worobey’s article is another nail in the coffin of the Wuhan lab conspiracy theory, concocted by the fascist ideologue Stephen K. Bannon and promoted by the New York Times, Washington Post and Wall Street Journal.

“It is yet another piece of data that points to the so-called ‘natural’ origin in the wildlife farms and market system,” said a source close to an earlier WHO-China joint study on the origins of COVID-19.’

Read here (Defend Democracy Press, Nov 20, 2021)

Thursday 18 November 2021

Dissecting the early Covid-19 cases in Wuhan: Michael Worobey

‘With SARS, live-animal markets continued to sell infected animals for many months, allowing zoonotic spillover to be established as the origin and revealing multiple independent jumps from animals into humans. Unfortunately, no live mammal collected at Huanan Market or any other live-animal market in Wuhan has been screened for SARS-CoV-2–related viruses, and Huanan Market was closed and disinfected on 1 January 2020. Nevertheless, that most early symptomatic cases were linked to Huanan Market—specifically to the western section where raccoon dogs were caged—provides strong evidence of a live-animal market origin of the pandemic.

‘This would explain the extraordinary preponderance of early COVID-19 cases at one of the handful of sites in Wuhan—population 11 million—that sell some of the same animals that brought us SARS. Although it may never be possible to recover related viruses from animals if they were not sampled at the time of emergence, conclusive evidence of a Huanan Market origin from infected wildlife may nonetheless be obtainable through analysis of spatial patterns of early cases and from additional genomic data, including SARS-CoV-2–positive samples from Huanan Market, as well as through integration of additional epidemiologic data. Preventing future pandemics depends on this effort.’

Read here (Science, Nov 16, 2021)

Saturday 18 September 2021

Bats in Laos caves found to carry coronaviruses that share key feature with Sars-CoV-2

‘Bats dwelling in limestone caves in northern Laos were found to carry coronaviruses that share a key feature with Sars-CoV-2, moving scientists closer to pinpointing the cause of Covid-19. Researchers at France's Pasteur Institute and the University of Laos looked for viruses similar to the one that causes Covid-19 among hundreds of horseshoe bats.

‘They found three with closely matched receptor binding domains - the part of the coronavirus' spike protein used to bind to human ACE-2, the enzyme it targets to cause an infection. The finding, reported in a paper released on Friday (Sept 17) that is under consideration for publication by Nature journal, shows that viruses closely related to Sars-CoV-2 exist in nature, including in several Rhinolophus, or horseshoe bat, species. The research supports the hypothesis that the pandemic began from a spillover of a bat-borne virus.’

Read here (Straits Times, Sept 18, 2021)

Friday 3 September 2021

Health officials quietly moved the date of the 1st US COVID-19 death to January 2020

‘The first recorded death from COVID-19 in the U.S. occurred a month earlier than previously thought: A Kansas woman's death certificate was recently amended to say she died from the disease in January 2020, according to news reports.

‘The 78-year-old woman, Lovell "Cookie" Brown, died on Jan. 9, 2020 in Leavenworth, Kansas, several weeks before the first cases of COVID-19 were identified in the U.S., according to The Mercury News. Initially, Brown's death certificate said she died of a stroke and chronic obstructive lung disease. But in May 2021, her doctors quietly updated the certificate to add "COVID-19 pneumonia" as a cause of death, The Mercury News reported...

‘Before her death, Brown had experienced symptoms of headache, fever, diarrhea and body aches, and on Christmas Day 2019, her family remembered Brown saying that her favorite foods tasted bland, The Mercury News reported. When she began gasping for air, Brown was rushed to the hospital, where she spent a week in the ICU before her death.’

Read here (LiveScience, Sept 4, 2021)

Wednesday 18 August 2021

The origins of SARS-CoV-2: A critical review

Since the first reports of a novel severe acute respiratory syndrome (SARS)-like coronavirus in December 2019 in Wuhan, China, there has been intense interest in understanding how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in the human population. Recent debate has coalesced around two competing ideas: a “laboratory escape” scenario and zoonotic emergence. Here, we critically review the current scientific evidence that may help clarify the origin of SARS-CoV-2.

We contend that although the animal reservoir for SARS-CoV-2 has not been identified and the key species may not have been tested, in contrast to other scenarios there is substantial body of scientific evidence supporting a zoonotic origin. Although the possibility of a laboratory accident cannot be entirely dismissed, and may be near impossible to falsify, this conduit for emergence is highly unlikely relative to the numerous and repeated human-animal contacts that occur routinely in the wildlife trade. Failure to comprehensively investigate the zoonotic origin through collaborative and carefully coordinated studies would leave the world vulnerable to future pandemics arising from the same human activities that have repeatedly put us on a collision course with novel viruses.

Read here (Cell, Aug 18, 2021). Download PDF here

Friday 14 May 2021

Investigate the origins of Covid-19: ‘Take hypotheses about both natural and laboratory spillovers seriously’

‘As scientists with relevant expertise, we agree with the WHO director-general, the United States and 13 other countries, and the European Union that greater clarity about the origins of this pandemic is necessary and feasible to achieve. We must take hypotheses about both natural and laboratory spillovers seriously until we have sufficient data. A proper investigation should be transparent, objective, data-driven, inclusive of broad expertise, subject to independent oversight, and responsibly managed to minimize the impact of conflicts of interest. Public health agencies and research laboratories alike need to open their records to the public. Investigators should document the veracity and provenance of data from which analyses are conducted and conclusions drawn, so that analyses are reproducible by independent experts.’

Read here (Science, May 14, 2021)

Wednesday 5 May 2021

The origin of Covid: Did people or nature open Pandora’s box at Wuhan?

‘If the case that SARS2 originated in a lab is so substantial, why isn’t this more widely known? As may now be obvious, there are many people who have reason not to talk about it. The list is led, of course, by the Chinese authorities. But virologists in the United States and Europe have no great interest in igniting a public debate about the gain-of-function experiments that their community has been pursuing for years.

‘Nor have other scientists stepped forward to raise the issue. Government research funds are distributed on the advice of committees of scientific experts drawn from universities. Anyone who rocks the boat by raising awkward political issues runs the risk that their grant will not be renewed and their research career will be ended. Maybe good behavior is rewarded with the many perks that slosh around the distribution system. And if you thought that Andersen and Daszak might have blotted their reputation for scientific objectivity after their partisan attacks on the lab escape scenario, look at the second and third names on this list of recipients of an $82 million grant announced by the National Institute of Allergy and Infectious Diseases in August 2020.

‘The US government shares a strange common interest with the Chinese authorities: Neither is keen on drawing attention to the fact that Shi’s coronavirus work was funded by the US National Institutes of Health. One can imagine the behind-the-scenes conversation in which the Chinese government says, “If this research was so dangerous, why did you fund it, and on our territory too?” To which the US side might reply, “Looks like it was you who let it escape. But do we really need to have this discussion in public?”

‘Fauci is a longtime public servant who served with integrity under President Trump and has resumed leadership in the Biden Administration in handling the COVID-19 epidemic. Congress, no doubt understandably, may have little appetite for hauling him over the coals for the apparent lapse of judgment in funding gain-of-function research in Wuhan.

‘To these serried walls of silence must be added that of the mainstream media. To my knowledge, no major newspaper or television network has yet provided readers with an in-depth news story of the lab escape scenario, such as the one you have just read, although some have run brief editorials or opinion pieces. One might think that any plausible origin of a virus that has killed three million people would merit a serious investigation. Or that the wisdom of continuing gain-of-function research, regardless of the virus’s origin, would be worth some probing. Or that the funding of gain-of-function research by the NIH and NIAID during a moratorium on such research would bear investigation. What accounts for the media’s apparent lack of curiosity?

‘The virologists’ omertà is one reason. Science reporters, unlike political reporters, have little innate skepticism of their sources’ motives; most see their role largely as purveying the wisdom of scientists to the unwashed masses. So when their sources won’t help, these journalists are at a loss.

‘Another reason, perhaps, is the migration of much of the media toward the left of the political spectrum. Because President Trump said the virus had escaped from a Wuhan lab, editors gave the idea little credence. They joined the virologists in regarding lab escape as a dismissible conspiracy theory. During the Trump administration, they had no trouble in rejecting the position of the intelligence services that lab escape could not be ruled out. But when Avril Haines, President Biden’s director of national intelligence, said the same thing, she too was largely ignored. This is not to argue that editors should have endorsed the lab escape scenario, merely that they should have explored the possibility fully and fairly.

‘People round the world who have been pretty much confined to their homes for the last year might like a better answer than their media are giving them. Perhaps one will emerge in time. After all, the more months pass without the natural emergence theory gaining a shred of supporting evidence, the less plausible it may seem. Perhaps the international community of virologists will come to be seen as a false and self-interested guide. The common sense perception that a pandemic breaking out in Wuhan might have something to do with a Wuhan lab cooking up novel viruses of maximal danger in unsafe conditions could eventually displace the ideological insistence that whatever Trump said can’t be true.

‘And then let the reckoning begin.’

Read here (Bulletin of the Atomic Scientists, May 5, 2021)

Wednesday 14 April 2021

A coronavirus epidemic may have hit East Asia about 25,000 years ago

‘An ancient coronavirus, or a closely related pathogen, triggered an epidemic among ancestors of present-day East Asians roughly 25,000 years ago, a new study indicates.

‘Analysis of DNA from more than 2,000 people shows that genetic changes in response to that persistent epidemic accumulated over the next 20,000 years or so, David Enard, an evolutionary geneticist at the University of Arizona in Tucson, reported April 8 at the virtual annual meeting of the American Association of Physical Anthropologists. The finding raises the possibility that some East Asians today have inherited biological adaptations to coronaviruses or closely related viruses.

‘The discovery opens the way to exploring how genes linked to ancient viral epidemics may contribute to modern disease outbreaks, such as the COVID-19 pandemic. Genes with ancient viral histories might also provide clues to researchers searching for better antiviral drugs, although that remains to be demonstrated.’

Read here (ScienceNews, Apr 14, 2021)

Tuesday 30 March 2021

Data withheld from WHO team probing Covid-19 origins in China: Tedros

‘Although the team concluded that a leak from a Wuhan laboratory was the least likely hypothesis for the virus that causes COVID-19, Tedros said the issue required further investigation, potentially with more missions to China. "I do not believe that this assessment was extensive enough," he told member states in remarks released by the WHO. "Further data and studies will be needed to reach more robust conclusions."

‘The WHO team's leader, Peter Ben Embarek, told a press briefing it was "perfectly possible" the virus had been circulating in November or October 2019 around Wuhan, and so potentially spreading abroad earlier than documented so far. "We got access to quite a lot of data in many different areas, but of course there were areas where we had difficulties getting down to the raw data and there are many good reasons for that," he said, citing privacy laws and other restrictions.’

Read here (Reuters, Mar 31, 2021)

Monday 29 March 2021

WHO says Covid-19 likely passed from bats to humans through another animal

‘The coronavirus probably spread from bats to humans via another animal, with the likelihood it was leaked from a lab in China “extremely unlikely”, according to the long-awaited results of a joint World Health Organisation-China study into the origins of Covid-19 reported by the Associated Press. 

‘The findings align with what researchers said last month, at the end of their mission to Wuhan, the central Chinese city where the first Covid cases emerged at the end of 2019, and in their subsequent public comments, including to Bloomberg News.

‘The scientists proposed further research in every area except the lab leak hypothesis, the AP reported on Monday (March 29), citing a draft copy of the report, which it said left many questions unanswered.’

Read here (Straits Times, Mar 29, 2021)

Thursday 25 March 2021

Did former CDC director offer a ham sandwich theory of Covid-19? Maybe. Maybe not.

‘As Robert Redfield awoke Friday morning, he found himself transformed in his TV into a gigantic target of viral scorn.

‘The former director of the Centers for Disease Control and Prevention (CDC) lifted many expert eyebrows from their microscopes, telling CNN’s Sanjay Gupta he believes the coronavirus responsible for COVID-19 originated in a lab in China. In clips CNN aired from an upcoming special this Sunday (which Gupta dubbed an “autopsy” of the pandemic), Redfield dismissed the possibility that the virus could have evolved sufficiently on its own to have “somehow jumped” quickly from bats to humans. “I just don’t think this makes biological sense,” Redfield told Gupta, arguing it’s easier to conclude that the virus gained greater efficiency at infecting humans inside a lab.

Read here (Bulletin of Atomic Scientists, Mar 26, 2021)

China’s exotic farms may be a missing link behind the pandemic’s leap to people

‘Given that more than a year passed between late 2019, when the disease was linked to the market, and December 2020, when China says it shut down all its food-supplying wildlife farms, acquiring such evidence may prove impossible. Still, filling in gaps about how the virus may have leaped to humans is essential for understanding the COVID-19 pandemic and combating future zoonotic diseases.

‘Yunnan, the southern Chinese province where many of the now-shuttered wildlife farms are located, is also where virologists found a bat virus almost identical to the coronavirus circulating in humans. Some wildlife farms sold animals that can be infected with other coronaviruses, including civets, so scientists suspect that these species may also be susceptible to SARS-CoV-2, the virus that causes COVID-19. “Potentially, some of these animals were infected at those farms and then brought the virus into the market,” Peter Ben Embarek, the Danish food safety scientist heading WHO’s delegation, told Science in February, after he and the WHO team returned from China, adding that more testing was needed.’

Read here (National Geographic, Mar 25, 2021)

Wednesday 17 March 2021

Lab leak: A scientific debate mired in politics — and unresolved

‘More than a year into the SARS-CoV-2 pandemic, some scientists say the possibility of a lab leak never got a fair look...

‘As it stands now, pandemic preparedness faces two simultaneous fronts. On the one hand, the world has experienced numerous pandemic and epidemic outbreaks in the last 20 years, including SARS, chikungunya, H1N1, Middle East Respiratory virus, several Ebola outbreaks, three outbreaks of norovirus, Zika, and now SARS-CoV-2. Speaking of coronaviruses, says Ralph Baric, an epidemiologist at the University of North Carolina, Chapel Hill, “it’s hard to imagine there aren’t variants” in bats with mortality rates approaching MERS’ 30 percent that also have “a transmissibility that is much more efficient. And that is terrifying.” Baric is emphatic that genetic research with viruses is essential to staying ahead of the threat.

‘Yet according to Richard Ebright, a molecular biologist at Rutgers University, lab-release dangers are growing as well. The risk increases in proportion with the number of labs handling bioweapons and potential pandemic pathogens (more than 1,500 globally in 2010), he says, many of them, like the Wuhan lab, located in urban areas close to international airports. “The most dramatic expansion has occurred in China during the last four years — driven as an arms-race-style reaction to biodefense expansion in the U.S., Europe, and Japan,” Ebright wrote in an email to Undark. “China opened two new BSL-4 facilities, in Wuhan and in Harbin, in the last four years,” he added, “and has announced plans to establish a network of hundreds of new BSL-3 and BSL-4 labs.”

Read here (Undark, Mar 17, 2021)

Sunday 7 March 2021

In 2018, diplomats warned of risky Coronavirus experiments in a Wuhan lab. No one listened

‘Knowing the significance of the Wuhan virologists’ discovery, and knowing that the WIV’s top-level biosafety laboratory (BSL-4) was relatively new, the U.S. Embassy health and science officials in Beijing decided to go to Wuhan and check it out. In total, the embassy sent three teams of experts in late 2017 and early 2018 to meet with the WIV scientists, among them Shi Zhengli, often referred to as the “bat woman” because of her extensive experience studying coronaviruses found in bats.

‘When they sat down with the scientists at the WIV, the American diplomats were shocked by what they heard. The Chinese researchers told them they didn’t have enough properly trained technicians to safely operate their BSL-4 lab. The Wuhan scientists were asking for more support to get the lab up to top standards...

‘Taken together, those two points—a particularly dangerous groups of viruses being studied in a lab with real safety problems—were intended as a warning about a potential public-health crisis, one of the cable writers told me. They kept the cables unclassified because they wanted more people back home to be able to read and share them, according to the cable writer. But there was no response from State Department headquarters and they were never made public. And as U.S.-China tensions rose over the course of 2018, American diplomats lost access to labs such as the one at the WIV.’

Read here (Politico, March 8, 2021)

Tuesday 2 March 2021

The search for animals harbouring coronavirus — and why it matters

‘Ever since the coronavirus started spreading around the world, scientists have worried that it could leap from people into wild animals. If so, it might lurk in various species, possibly mutate and then resurge in humans even after the pandemic has subsided.

‘That would bring the tale of SARS-CoV-2 full circle, because wild animals probably brought it to humans in the first place. Strong evidence suggests that the virus originated in horseshoe bats (Rhinolophus spp.), possibly hitching a ride on other animals before infecting people1. In the current stage of the pandemic, with hundreds of thousands of confirmed COVID-19 infections every day, people are still driving transmission of SARS-CoV-2. But years from now, when community spread has been suppressed, a reservoir of SARS-CoV-2 in free-roaming animals could become a recalcitrant source of new flare-ups.’

Read here (Nature, Mar 2, 2021)

Thursday 25 February 2021

Where did Covid come from? Five mysteries that remain

‘In the wake of the World Health Organization’s investigation, there are still key questions about when, where and how the pandemic began.

  1. Was the virus circulating in Wuhan before the first known cases?
  2. Was the virus spreading in people outside China before December 2019?
  3. What was the role of the Huanan market?
  4. Did frozen wild-animal meat have a role in the early spread of the virus?
  5. Was the virus circulating in animals in China before the pandemic?

Read here (Nature, Feb 26, 2021)

Sunday 21 February 2021

I was the Australian doctor on the WHO’s Covid-19 mission to China. Here’s what we found about the origins of the coronavirus

‘As part of the mission, we met the man who, on December 8, 2019, was the first confirmed COVID-19 case; he’s since recovered. We met the husband of a doctor who died of COVID-19 and left behind a young child. We met the doctors who worked in the Wuhan hospitals treating those early COVID-19 cases, and learned what happened to them and their colleagues. We witnessed the impact of COVID-19 on many individuals and communities, affected so early in the pandemic, when we didn’t know much about the virus, how it spreads, how to treat COVID-19, or its impacts.

‘We talked to our Chinese counterparts — scientists, epidemiologists, doctors — over the four weeks the WHO mission was in China. We were in meetings with them for up to 15 hours a day, so we became colleagues, even friends. This allowed us to build respect and trust in a way you couldn’t necessarily do via Zoom or email.

‘This is what we learned about the origins of SARS-CoV-2:

  • Animal origins, but not necessarily at the Wuhan markets
  • Frozen or refrigerated food not ruled out in the spread
  • Extremely unlikely the virus escaped from a lab

Read here (The Conversation, Feb 22, 2021)

Monday 15 February 2021

NY Times lies to say WHO investigators dissatisfied with Chinese cooperation

This story carries the rebuttals on Twitter by two WHO expert-team members, Peter Daszak, British zoologist, and Thea Kølsen Fischer, a Danish epidemiologist. It also provides a background to the story, quoting various findings elsewhere in the world. The earlier studies suggest that the Covid-19 virus could have circulated in Europe before it surfaced in Wuhan. 

Read here (Scoop NZ, Feb 15, 2021)

Sunday 14 February 2021

WHO experts slam NYT for twisting, misquoting their words on virus origins probe

‘WHO experts who recently visited Wuhan slammed the New York Times for twisting their words and casting shadows over the efforts to uncover the origins of the virus, after the newspaper accused China of refusing to hand over sensitive data to WHO experts.

‘The report by New York Times titled “On WHO Trip, China Refused to Hand Over Important Data” accuses China of failing to share important data that may help in identifying the origins of the virus and prevent future outbreaks.

 ‘After the report was published, two WHO experts [Peter Daszak, British zoologist and Thea Kølsen Fischer, a Danish epidemiologist] slammed New York Times for misquoting them in the report to fit its own narrative, with the report casting a shadow over the scientific work of seeking for virus origin.’

Read here (Global Times, Feb 14, 2021)

US and UK in a spat with China over WHO probe on Covid-19

  • White House cites 'deep concerns' about WHO Covid-19 report, demands early data from China (read here)
  • UK says it shares US concerns over WHO COVID-19 mission to China (read here)
  • China fires back at US allegations of lack of transparency over Covid-19 probe (read here)

All reports on Channel News Asia, Feb 14, 2021

Worst ever Covid variant? Omicron

John Campbell shares his findings on Omicron.  View here (Youtube, Nov 27, 2021)