The politics of stopping pandemics

‘As the world nervously watches the rollout of the various covid-19 vaccines and surveys the human and economic cost of the pandemic, this period of optimism is hard to imagine. Yet Hotez, a pediatrician and a specialist in tropical infectious diseases at Baylor College of Medicine who co-directs a vaccine-development center at the Texas Children’s Hospital, shows that pandemics had been rebounding well before the first covid-19 cases emerged in Wuhan. His book draws lessons from the field of tropical infectious diseases, and also from his international work as a science envoy—a position created jointly by the State Department and the White House—during Barack Obama’s Presidency. 

‘Hotez is perhaps uniquely positioned to expound a broad vision that marries science with geopolitics. (In the past year, he has been a prominent TV expert on the pandemic.) We learn not only about familiar scourges such as polio and diphtheria but also about a host of so-called neglected tropical diseases, including dengue, leishmaniasis, schistosomiasis, and Chagas. He melds an account of their biology with documentation of the social and political factors that enable them to spread, and passionately insists that we cannot prevent pandemics in isolation from wider global currents. He identifies a cluster of non-medical drivers of deadly outbreaks—war, political instability, human migration, poverty, urbanization, anti-science and nationalist sentiment, and climate change—and maintains that advances in biomedicine must be accompanied by concerted action on these geopolitical matters.’

Read here (The New Yorker, Mar 29, 2021)

The influence of the anti-vaccine movement

‘To try to understand why anti-vaccine sentiment is so prevalent in the United States, I recently spoke by phone with Dr. Peter Hotez, a professor of pediatrics and molecular virology at Baylor College of Medicine, and the co-director of the Texas Children’s Center for Vaccine Development. In March, he will publish a book called “Preventing the Next Pandemic: Vaccine Diplomacy in a Time of Anti-Science.” During our conversation, which has been edited for length and clarity, we discussed the historical reasons for vaccine skepticism among many Black Americans, how doctors can speak the truth without appearing political, and how the fight over vaccines became so similar to the fight over every political issue in America.’

Read here (The New Yorker, Dec 18, 2020)

When a virus is the cure

‘As bacteria grow more resistant to antibiotics, bacteriophage therapy is making a comeback...

‘Phages, or bacteriophages, are viruses that infect only bacteria. Each kingdom of life—plants, animals, bacteria, and so on—has its own distinct complement of viruses. Animal and plant viruses have always received most of our scientific attention, because they pose a direct threat to our health, and that of our livestock and crops. The well-being of bacteria has, understandably, been of less concern, yet the battle between viruses and bacteria is brutal: scientists estimate that phages cause a trillion trillion infections per second, destroying half the world’s bacteria every forty-eight hours. As we are now all too aware, animal-specific viruses can mutate enough to infect a different animal species. But they will not attack bacteria, and bacteriophage viruses are similarly harmless to animals, humans included. Phage therapy operates on the principle that the enemy of our enemy could be our friend.’

Read here (The New Yorker, Dec 14, 2020) 

What an FDA committee weighed in voting for the Pfizer Covid vaccine

‘An all-day hearing of the Food and Drug Administration’s vaccine advisory committee closed, on Thursday evening, with a vote to recommend an Emergency Use Authorization of the Pfizer-BioNTech covid-19 vaccine for people sixteen and older. 

‘The proceedings involved a great deal of data and technical talk, but might be quickly summarized this way: there are things we still do not know about the vaccine, but nothing that we do know looks bad. Indeed, the vaccine looks very, very good. And its known goodness applies to a diverse range of populations, including Black and Latinx and older people. An F.D.A. analysis of the raw data, released earlier this week, confirmed previous reports that the vaccine’s efficacy in preventing disease in trial participants was close to ninety-five per cent. That number held up under questioning from committee members, who represented a range of specialties, from pediatrics to virology, throughout the eight hours of the hearing. 

‘Amid a pandemic—on a day when more than three thousand people in this country were reported to have died from covid-19—that result is far more than it would have been reasonable to hope for even a couple of months ago. As Dr. Doran Fink, of the F.D.A., said in one of the day’s presentations, there is no “adequate, approved, and available alternative.” It was a long day, but a reassuring and even energizing one.’

Read here (The New Yorker, Dec 11, 2020)

The billionaires who profited from the pandemic should help pay for our recovery

‘The collective wealth gain of roughly a trillion dollars that the billionaires have enjoyed is more “than it would cost to send a stimulus check of $3,000 to every one of the roughly 330 million people in America,” the report states. “A family of four would receive over $12,000.” The report points out that a trillion dollars is also “double the two-year estimated budget gap of all state and local governments”—the deficit facing states that will certainly prompt them to make more cuts in public jobs and services if it isn’t addressed. The authors of the report don’t argue that taxing the recent gains of the mega-rich would cover the entire fiscal cost of the pandemic. They stress, instead, the undoubted fact that, at the very apex of U.S. society, there is now a staggering—and historic—amount of wealth that could be taxed.’

Read here (The New Yorker, Dec 10, 2020)

How China controlled the coronavirus: From the micro point of view of an American teaching and learning in Sichuan during the pandemic

‘Despite the political indoctrination involved in Chinese schooling, the system teaches people to respect science. Hard work is another core value, and somehow society has become more prosperous without losing its edge. Nearly a quarter century ago, I taught young people who were driven by the desire to escape poverty; these days, my middle-class students seem to work at least as hard, because of the extreme competitiveness of their environment. Such qualities are perfect for fighting the pandemic, at least when channelled effectively by government structures. In comparison, the American response often appears passive—even enlightened citizens seem to believe that obeying lockdown orders and wearing masks in public is enough. But any attempt to control the virus requires active, organized effort, and there needs to be strong institutional direction.

‘Instead, the flailing American leadership seems more interested in finding scapegoats, sometimes with a racial tinge—the Kung Flu and the China Virus. Throughout the spring, the Chinese government periodically responded by lashing out at the U.S. and other foreign countries, but such tensions had little impact on my life in Chengdu. Daily interactions remained friendly, and people often made a point of telling me that the problems between governments had nothing to do with our personal relationships.’

Read here (The New Yorker, August 17, 2020)