John Campbell shares three theories on sudden drop of Covid-19 cases in Japan: (1) Ivermectin allowed as a treatment on August 13, two weeks before the precipitous drop in cases (2) Ituro Inoue, professor, National Institute of Genetics, on the virus’s error-correcting protein, nsp14 (3) More people in Asia have a defense enzyme called APOBEC3A that attacks RNA viruses, including the SARS-CoV-2 virus that causes COVID-19.
View here (Youtube, Nov 24, 2021)
Pharmacodynamic analyses that show that the new Pfizer antiviral works in the same way as ivermectin -- as a SARS-CoV-2-3CL protease inhibitor. Plenty of links attached to the video to back the claim.
View here (Youtube, Nov 9, 2021)
We don’t recommend Ivermectin to treat Covid-19, says health DG. Read here (Free Malaysia Today, Nov 3, 2021)
Ivermectin study: Doctor whose clinic was raided stands his ground, disputes findings Read here (Free Malaysia Today, Nov 3, 2021)
I’ll study findings, says MP who urged use of Ivermectin for Covid treatment Read here (Free Malaysia Today, Nov 3, 2021)
‘Studies suggesting ivermectin is an effective Covid treatment relied on evidence ‘that has substantially evaporated under close scrutiny’, fresh research shows...
‘On Thursday (Sept 23, 2021), the prestigious medical journal Nature Medicine published an article authored by concerned epidemiologists and researchers who interrogated studies on ivermectin. “Many hundreds of thousands of patients have been dosed with ivermectin, relying on an evidence base that has substantially evaporated under close scrutiny,” the authors wrote.
“Several … studies that claim a clinical benefit for ivermectin are similarly fraught, and contain impossible numbers in their results, unexplainable mismatches between trial registry updates and published patient demographics, purported timelines that are not consistent with the veracity of the data collection, and substantial methodological weaknesses.”
Read here (The Guardian, Sept 25, 2021)
Read here (Nature Medicine, Sept 22, 2021)
‘In this randomized clinical trial that included 476 patients, the duration of symptoms was not significantly different for patients who received a 5-day course of ivermectin compared with placebo (median time to resolution of symptoms, 10 vs 12 days; hazard ratio for resolution of symptoms, 1.07).
‘The findings do not support the use of ivermectin for treatment of mild COVID-19, although larger trials may be needed to understand effects on other clinically relevant outcomes.’
Read here (JamaNetwork, Mar 4, 2021)
‘The Front Line COVID-19 Critical Care Alliance (FLCCC) has issued a public statement in response to a press release recently issued by Merck.
‘The FLCCC Alliance reports that the Merck release of February 4, 2021— which concluded that there was no meaningful evidence for the clinical efficacy of ivermectin in patients with COVID-19 disease — did not provide any scientific data or analyses by Merck to support their conclusion.
‘Dr. Pierre Kory, President and Chief Medical Officer of the FLCCC said that, "The company's disregard for the most current medical evidence is an evidentiary indictment of their uncorroborated position. Merck's press release will cause governments, health authorities, medical providers, business leaders, and citizens to retreat from pursuing a medical agent that, according to our recent peer-reviewed and accepted publication to the highly regarded Frontiers in Pharmacology, has been proven to be an effective and globally available agent to prevent and treat every phase of COVID-19 disease."
Read here (PRWeb, Feb 16, 2021)
‘On Jan 22, it was announced that the Ministry of Health (MOH) would be conducting clinical trials for two medicines, Ivermectin and Favipiravi, to determine their efficacy in treating Covid-19. Health Director-General Tan Sri Dr Noor Hisham Abdullah has acknowledged that Ivermectin "is cheap, easily available and safe for use." But in Malaysia, it is only licensed for use in animals...
‘In view of the worsening case on Covid-19 infections in our country, many unanswered questions and lack of data on the long term safety aspects of the Pfizer experimental mRNA vaccine (which our country has already been ordered) and the current production problems faced by vaccine manufacturers overseas (with the possibility of delays), the government here should have a "PLAN B".
‘It should quickly approve Ivermectin to provide a safe, cheap and effective "weapon" against Covid-19. The clinical trials by MOH on the efficacy of Ivermectin can continue but we should not need to wait (and let many more people suffer and die from Covid-19 in the meantime) since Ivermectin has ALREADY been PROVEN to be VERY SAFE over the last 30 years or so.
‘What have we got to lose by approving Ivermectin today in Malaysia as an option for doctors to prescribe against Covid-19?’
Read here (New Straits Times, Feb 7, 2021)
‘Merck, known as MSD outside the United States and Canada, today affirmed its position regarding use of ivermectin during the COVID-19 pandemic. Company scientists continue to carefully examine the findings of all available and emerging studies of ivermectin for the treatment of COVID-19 for evidence of efficacy and safety. It is important to note that, to-date, our analysis has identified:
We do not believe that the data available support the safety and efficacy of ivermectin beyond the doses and populations indicated in the regulatory agency-approved prescribing information.
Read here (Merck press statement, Feb 4, 2021)
‘A team of researchers based in Peru and the US recently examined the role of the anti-parasitic drug ivermectin in treating COVID-19. The team has released their findings on the medRxiv preprint server... (link below).
Study details
‘The researchers included 12 qualitative and five quantitative studies, mostly preprints. These studies originated from all over the world, two being from the U.S., two from Spain, two from South America, one each from Iraq and Iran, and four from Bangladesh.
‘Altogether, there were around 7,400 participants, with a mean age of 47.5 years. About 60% were male. The treatment protocols for all included studies comprised ivermectin either alone or in combination with another anti-inflammatory, antibiotic or blood-thinning drug like azithromycin, hydroxychloroquine, dexamethasone, enoxaparin, aspirin or dicloxacillin...
‘Ivermectin was not significantly associated with a lower mortality or higher recovery of patients in this meta-analysis. However, the majority of studies were preprints, allowing for later changes in the data on which these conclusions are based.’
Read here (Medical News, Feb 1, 2021)
Read original study here (Medrxiv, Jan 27, 2021)
‘The Front Line COVID-19 Critical Care Alliance (FLCCC) has issued an open letter to researchers in England at the University of Oxford who are planning to conduct a double-blind, Randomized Controlled Trial (RCT) of ivermectin for use in COVID-19. The letter states, “Our manuscript, which reviewed both epidemiologic data and the existing clinical trials evidence base, concluded that ivermectin should be the standard of care in COVID-19.”
Read here (Newswire, Jan 25, 2021)
Download FLCCC Aliiance PDF here
‘The University of Oxford soon kicks “the PRINCIPLE Trial” into a higher gear now, in what they consider a pathbreaking “high-quality trial” of Ivermectin, a generic drug already evidencing significant efficacy in over two dozen clinical trials around the world, according to some researchers. The UK government also backs this pivotal study via the Department of Health and Social Care.
‘Searching for early-onset, home-based ambulatory treatments for COVID-19, the PRINCIPLE Trial seeks to meet a gap in research in the world’s richest nations to date. Nearly all of the taxpayer-financed research-based expenditures of governments in the US, UK and Europe, for example, have gone into vaccines, novel monoclonal antibodies, and novel therapeutics, with an emphasis on treating severely ill patients.
‘Ivermectin, hailed as the “wonder drug” or “the People’s medicine” for COVID-19, gains growing attention worldwide made more widely available, frankly, partly due to TrialSite’s consistent chronicling of these trials around the world since the original University of Monash breakthrough.’
Read here (TrialSite News, Jan 23, 2021)
Added value of this study: ‘This pilot, randomized, placebo-controlled, double blind trial failed to show a reduction in the proportion of PCR-positive patients seven days after ivermectin treatment; yet it shows a reduction in the self-reported anosmia/hyposmia and a (non-statistically significant) tendency to lower viral loads and lower IgG titers which presumably reflect milder disease.’
Implications of all the available evidence: ‘The positive signal found in this pilot together with emerging evidence from animal models and other clinical trials warrants the conduction of larger trials using ivermectin for the early treatment of COVID-19.’
Read here (EClinicalMedicine, The Lancet, Jan 19, 2021)
‘Afriforum insists that investigations regarding studies that have already been conducted globally on the use of Ivermectin be carried out as soon as possible to confirm if this drug can be used effectively in the prevention and treatment of the coronavirus. “A large range of studies in various countries show that Ivermectin can possibly be effective in the treatment of the virus,” Barend Uys, Afriforum’s head of research said.
‘According to him, it was irrational to approve the use of a vaccine that had been developed within months while at the same time banning the use of a drug that had been proven safe and been in use for four decades. “Farmers have been using Ivermectin as a livestock product for many years and it is immediately available in their medicine cabinets,” said Uys.’
Read here (IOL, Jan 16, 2021)
‘Scientists have warned against taking an anti-parasite drug as a treatment for Covid-19 despite headlines that have touted it as a cure. Facebook posts and articles endorsing ivermectin have proliferated in Brazil, France, South Africa and South Korea as governments around the world scramble to roll out vaccination programmes.
‘But health agencies say that there is not enough evidence to promote the drug as a remedy for coronavirus -- and that research into the question has often been unsound. Ivermectin has long been used to treat parasites such as head lice and has been widely distributed in sub-Saharan Africa since the 1990s to treat river blindness.’
Read here (France 24/AFP, Jan 15, 2021)
‘The National Institutes (NIH) has issued a new statement on the use of the anti-parasitic drug ivermectin for the treatment of COVID-19. Previously, it recommended against this treatment, but now states that its Panel “has determined that there are insufficient data to recommend either for or against the use of ivermectin for the treatment of COVID-19.”
‘The Association of American Physicians and Surgeons (AAPS) notes that there are now 49 ivermectin studies summarized on c19study.com, 100 percent of which show favorable results. In contrast, there are very few studies of the antibody cocktails now being used under an Emergency Use Authorization.
‘NIH concludes from its current analysis that “results from adequately powered, well-designed, and well-conducted clinical trials are needed to provide further guidance on the role of ivermectin in the treatment of COVID-19.” The NIH may be responding to requests related to the testimony strongly favoring ivermectin in a Dec 8 Senate hearing before the Committee on Homeland Security and Governmental Affairs.’
Read here (Globe Newswire, Jan 15, 2021)
‘One week after Dr. Paul Marik and Dr. Pierre Kory – founding members of the Front Line Covid-19 Critical Care Alliance (FLCCC) – along with Dr. Andrew Hill, researcher and consultant to the World Health Organization (WHO), presented their data before the NIH Treatment Guidelines Panel, the NIH has upgraded their recommendation and now considers Ivermectin an option for use in COVID-19.
‘Their recommendation has now been upgraded to the same level as those for widely used monoclonal antibodies & convalescent plasma, which is a “neither for nor against” recommendation. The significance of this change is that the NIH has decided to no longer recommend against the use of ivermectin in the treatment of COVID-19 by the nation’s health care providers. A consequence of this change is that ivermectin has now been made a clear therapeutic option for patients.’
Read here and press release here (FLCCC Alliance, Jan 15, 2021)
‘Several factors distinguish the handling of the pandemic in the state but I aim to discuss a few in this article. Of the many innovative steps taken there are three clear winners.
‘First is the setting up of Team 11 — a group of 11 senior government officials tasked with managing different aspects like surveillance and contact tracing, testing and treatment, sanitisation, containment, enforcement, doorstep delivery, issues of migrants, communication strategy, etc — in March itself...
‘The second winner is the Integrated Covid Command and Control Centre (ICCC) set up in every district. This is the nerve centre of pandemic management in the district, sending testing teams to different areas as per plan, ensuring surveillance and contact tracing, sending positive patients to different Covid hospitals or placing them under home isolation...
‘The third winner is the integrated data management portal (upcovid19tracks.in). It provides us with the ability to crunch and analyse data on a daily basis...
‘Let me also discuss two strategic interventions, out of many, which we have taken.
‘The first is the widespread use of the drug, ivermectin, not just for treatment of cases but also as a prophylactic. The state government provides free medicines to all patients in home isolation or in government COVID-19 facilities, which have more than 1.5 lakh beds. We have used the combination of ivermectin and doxycyclin to successfully treat over three lakh home-isolated patients with mild symptoms so far. This combination has also been used by the hospitals across the state for admitted COVID-19 patients. But what is more interesting is the state’s successful use of ivermectin as a prophylactic.
‘The second strategic intervention is the targeted testing of selected groups. We started doing this in June with residents of urban slums, workers at nursing homes, pharmacy shops, bus and auto drivers, shopkeepers, security guards in malls, hospitals, etc.’
Read here (Indian Express, Dec 17, 2021)
Dr John Campbell examines the evidence on ivermectin and suggests that health authorities the world over study its efficacy as a prophylactic and treatment for Covid-19; they should consider including it in the treatment regime if it is found to be effective.
View here (Youtube, Dec 12, 2020)
‘Numerous studies have provided evidence supporting the use of ivermectin to prevent and treat COVID-19, according to the Frontline COVID-19 Critical Care Alliance. Paul Marik, MD, FCCM, FCCP, founder of the alliance and a professor and chief of the division of pulmonary and critical care medicine at Eastern Virginia Medical School, said that ivermectin “is a safe drug that is exceedingly cheap.”
‘He added that “what is truly remarkable — this was a gift to us — ivermectin has high activity against COVID-19.” In a press conference, researchers said that ivermectin is an FDA-approved anti-parasitic drug that has been available for approximately 40 years and previously earned researchers a Nobel Prize.’
Read here (Healio, Dec 8, 2020)
FLCCC Alliance: Review of the emerging evidence demonstrating the efficacy of Ivermectin in the prophylaxis and treatment of COVID-19
Read PDF here (FLCCC Alliance, Dec 7, 2020)
‘A combination of FDA and TGA approved Ivermectin, Zinc and Doxycycline has shown positive results for COVID-19 and should be considered immediately to fight the pandemic' says CDD Medical Director Professor Thomas Borody...
‘Australia's The Centre for Digestive Disease (CDD) Medical Director Professor Thomas Borody MB, BS, BSc(Med), MD, PhD, DSc, FRACP,FACP,FACG, AGAF, says FDA and TGA approved Ivermectin which he uses regularly in his hospital, has shown positive results for COVID-19 and should be considered immediately to fight the pandemic. Ivermectin was discovered in the 1970s and is on the World Health Organization (WHO) list of essential medicines.
‘Professor Borody has used the same methodology with the COVID-19 Ivermectin Triple Therapy as he used when he developed the world’s first cure for peptic ulcers saving millions of lives around the globe. He says this combination of 3 approved “off the shelf” drugs could be the answer to Australia’s COVID-19 crisis. “If nothing else, make it available in aged care homes immediately. Our elderly are at the highest risk and this is a very safe option especially when we have nothing else except ventilators. Also, our frontline workers deserve more protection with a preventative medication like this, and as an emergency treatment if they test positive,” says Professor Borody.
“An Ivermectin tablet can cost as little as $2 – which could make it by far the cheapest, safest, and fastest cure for Australians and the Australian economy," he added.’
Read here (Biospectrum, August 6, 2020)