Covid-19 virus survives on skin five times longer than flu virus: Study

‘The Covid-19 virus remains active on human skin for nine hours, Japanese researchers have found, in a discovery they said showed the need for frequent hand washing to combat the Covid-19 pandemic. The pathogen that causes the flu survives on human skin for about 1.8 hours by comparison, said the study published this month in the Clinical Infectious Diseases journal.’

Read here (Straits Times, Oct 18, 2020)

Is the coronavirus a threat to democracy?

‘Researchers say the pandemic has been used to roll back democracy and human rights in 80 countries. The coronavirus pandemic is causing a worldwide crisis for democracy, according to Freedom House, a United States-based research group. In a new report, Freedom House identified 80 nations where democracy or human rights have been curtailed since the virus emerged at the end of last year.’

Watch panel discussion here (Aljazeera, Oct 4, 2020)

The Chinese scientist who sequenced the first Covid-19 genome speaks out about the controversies surrounding his work

‘Over the past few years, Professor Zhang Yongzhen has made it his business to sequence thousands of previously unknown viruses. But he knew straight away that this one was particularly nasty. It was about 1:30 p.m. on Jan. 3 that a metal box arrived at the drab, beige buildings that house the Shanghai Public Health Clinical Center. Inside was a test tube packed in dry ice that contained swabs from a patient suffering from a peculiar pneumonia sweeping China’s central city of Wuhan. But little did Zhang know that that box would also unleash a vicious squall of blame and geopolitical acrimony worthy of Pandora herself. Now, he is seeking to set the record straight.’

Read here (Time Magazine, August 24, 2020) 

Oxford developers of rapid Covid-19 test awarded RAEng President's Special Award

‘Professor Cui and his team from Oxford's Department of Engineering Science and OSCAR, the Oxford Suzhou Centre for Advanced Research, are one of the winners announced today of the Royal Academy of Engineering's President's Special Awards for Pandemic Service for their rapid viral RNA test for COVID-19.’

Read here (OUP, Aug 17, 2020) 

China's lead in coronavirus vaccines raises concern as well as hope

‘China has emerged as a leader in novel coronavirus vaccines, a development that will enhance it as a global power but also raises concerns over safety and the potential for Beijing to use its status in territorial disputes. The country has nine vaccine candidates in clinical trials, including five in Phase 3, the final stage of the process toward approval. This achievement is the result of years of state-led research on infectious diseases. Last week, Chinese drugmaker CanSino Biologics announced it would conduct a Phase 3 trial in Saudi Arabia with 5,000 volunteers. Of the 29 new vaccines in clinical trials around the world, nine are in China, the most of any country. Of the seven that are in Phase 3, China has five. Chinese vaccines are expected to be in practical use as early as the next few months.’

[This story is behind a paywall]

Read here (Nikkei Asian Review, August 17, 2020)

Hopes for a Covid-19 vaccine in early 2021, but that’s only the start of the story, experts say

‘With six Covid 19 vaccine candidates undergoing final clinical trials, initial data about whether they can protect people from the disease is expected to be available in the next two to three months, assuming all goes well. That gives hope to the possibility that a vaccine could hit the market by early next year...

“Most of the data so far supports the notion that they all do what it says on the tin: induce neutralising antibody and T-cells,” said Daniel Altmann, a professor in the department of medicine at Imperial College London. “But it is a long way from there to proof of safe, long-term, protective immunity.”

Read here (South China Morning Post, August 10, 2020)

German sniffer dogs show promise at detecting coronavirus

‘Scientists at the University of Veterinary Medicine Hanover have found that trained sniffer dogs could be used to detect COVID-19 in human samples with a relatively high rate of accuracy, a study published on Thursday revealed... The animals were able to positively detect SARS-CoV-2 infected secretions with an 83% success rate, and control secretions at a rate of 96%. The overall detection rate, combining both, was 94%.’

Read here (DW, July 23, 2020)

Inside the global quest to trace the origins of Covid-19 — and predict where it will go next

‘It has been 100 years since an infectious disease pushed the entire world’s population into hiding to the extent that COVID-19 has. And the primary approaches we take to combatting emerging microbes today are likewise centuries old: quarantine, hygiene and social distancing. We may never learn exactly where SARS-CoV-2 came from, and it’s clearly too late to prevent it from becoming a global tragedy. But extraordinary advances in scientific knowledge have given us new tools, like genetic sequencing, for a more comprehensive understanding of this virus than anyone could have imagined even a decade or two ago. These are already providing clues about how emerging viruses like SARS-CoV-2 operate and, most important, how they can be thwarted with more effective drugs and vaccines.’

Read here (Time Magazine, July 23, 2020)

Press releases by RECOVERY (Randomised Evaluation of Covid-19 Therapy) Trial, University of Oxford

This UK national clinical trial, conducted by researchers at the University of Oxford in concert with other relevant institutions, aims to identify treatments that may be beneficial for people hospitalised with suspected or confirmed COVID-19... A range of potential treatments have been suggested for COVID-19 but nobody knows if any of them will turn out to be more effective in helping people recover than the usual standard of hospital care which all patients will receive. The RECOVERY Trial is aimed at evaluating the efficacy of such treatments. It has made a series of press statements from end-March 2020. This link takes you to them.

Read here (RECOVERY Trial website)

The vaccine race

’Rarely has the fate of the world depended on an international competition like the one for a Covid-19 vaccine. It's a race against time, it's a race to save lives, it's a race for glory. Trials are underway. Who develops a vaccine first? Who gets to take it first? How much will vaccines cost? And will they be effective enough, or safe enough?’

Read here (Politico, June 30, 2020)

Coronavirus traces found in March 2019 sewage sample, Spanish study shows

‘Spanish virologists have found traces of the novel coronavirus in a sample of Barcelona waste water collected in March 2019, nine months before the Covid-19 disease was identified in China, the University of Barcelona said on Friday (June 26). The discovery of virus genome presence so early in Spain, if confirmed, would imply the disease may have appeared much earlier than the scientific community thought.’

Read here (Straits Times, June 27, 2020)

Antibody tests don't mean a ton right now. But that could change soon

‘In the study published in medRxiv, a preprint server for posting studies before they are peer-reviewed, a team at the Lindsley F. Kimball Research Institute of the New York Blood Center and Rockefeller University analyzed 370 plasma samples donated from people who recovered from COVID-19 and found some surprising results...

‘Overall, around 88% of the people generated varying levels of antibodies to the virus. But only about 10% of them had high levels that were able to neutralize the lab-based version of the COVID-19 virus—and, on the other side of the spectrum, 17% had almost no antibody response to their infection.’

Read here (Time Magazine, June 16, 2020)

Lancet editor spills the beans and the unfolding of a pharmaceutical scandal

‘In a videotaped interview on May 24, 2020, Dr [Philippe] Douste-Blazy provided insight into how a series of negative hydroxychloroquine studies got published in prestigious medical journals. He revealed that at a recent Chatham House top secret, closed door meeting attended by experts only, the editors of both, The Lancet and the New England Journal of Medicine expressed their exasperation citing the pressures put on them by pharmaceutical companies... [Douste-Blazy is a cardiologist and former French Health Minister who served as Under-Secretary General of the United Nations. He was a candidate in 2017 for Director of the World Health Organization]

‘The alarming findings and serious negative impact of the Lancet report led numerous scientists around the globe to scrutinise the report in detail. That scrutiny by legitimate, independent scientists has led to many serious questions about the integrity of the study, the authenticity of the data, and the validity of the methods the authors used... [many details are provided in this story]

Demonisation of favourable HCQ-AZ treatment studies: ‘Since publishing favourable reports about a treatment combination of two cheap, widely prescribed medicines: hydroxychloroquine and the antibiotic azithromycin, as a treatment of choice against Covid-19, Dr [Didier] Raoult has become the subject of intense demonisation by the corporate-influenced medical establishment, the media, and the [sic] who resort to this tactic whenever they lack evidence or legitimate grounds to support public health policies that cause people harm.’

Read here (Health Impact News, received on June 13, 2020)

The role of vitamin D in reducing risk of COVID-19: A brief survey of the literature

‘The evidence that higher vitamin D status is causally linked to lower risk of COVID-19 incidence, severity, and death continues to increase. This brief report outlines what has been learned through early June 2020 and provides links to some of the key references.

‘It should be noted that acceptance of the role of vitamin D supplementation will probably not be achieved before reports are published that demonstrate randomized controlled trials of vitamin D supplementation significantly reduced COVID-19 incidence or death. Several RCTs and observational studies regarding vitamin D supplementation and COVID-19 incidence and outcomes are either in the planning stage or in progress. The obvious groups to study are those at highest risk: dark-skinned people living at high latitudes, people in nursing homes or health care facilities; prisoners; factory workers such as in meat-packing facilities in the U.S.; health care workers. A major problem is that the powers that be see vitamin D as a threat to income and profit, so use the Disinformation Playbook to suppress positive information on vitamin D...

‘In a review published in early April, it was proposed that vitamin D supplementation could reduce the risk of COVID-19. Two mechanisms were identified: 1, reduced survival and replication of viruses through vitamin D-stimulated release of cathelicidin and defensins, and 2, reduced risk of the cytokine storm by reducing production of pro-inflammatory cytokines...’

Read here (Orthomolecular Medicine News Service, June 9, 2020)

What are the long-term health implications of Covid-19?

‘Six months into the Covid-19 pandemic, and with more than 380,000 people dead, the picture we have of Sars-CoV-2 remains opaque and unclear. Thousands of papers and reports have flooded the academic sphere during this period, as scientists have rushed to understand the virus, which, according to the journal Science, “acts like no pathogen humanity has ever seen”...

‘What initially appeared to be a predictable respiratory infection, similar to Sars or Avian flu, Sars-CoV-2 is now known to affect the lungs, brain, eyes, nose, heart, blood vessels, livers, kidneys and intestines — virtually every organ in the human body.’

Read here (The Independent, June 4, 2020)

Distancing and masks cut Covid-19 risk, says largest review of evidence

‘Keeping at least one metre apart and wearing face masks and eye protection are the best ways to cut the risk of Covid-19 infection, according to the largest review to date of studies on coronavirus disease transmission. In a review that pooled evidence from 172 studies in 16 countries, researchers found frequent handwashing and good hygiene are also critical - though even all those measures combined can not give full protection.’ The findings were published in The Lancet journal on Monday.

Read here (Malaysiakini, June 2, 2020)

The world needs Covid-19 vaccines. It may also be overestimating their power

‘In the public imagination, vaccines are often seen effectively as cure-alls, like inoculations against measles. Rather than those vaccines, however, the Covid-19 vaccines in development may be more like those that protect against influenza — reducing the risk of contracting the disease, and of experiencing severe symptoms should infection occur, a number of experts told STAT.’

Read here (STAT News, May 22, 2020)

Scientists in China believe new drug can stop Covid-19 ‘without vaccine’

‘A Chinese laboratory has been developing a drug it believes has the power to bring the coronavirus pandemic to a halt. A drug being tested by scientists at China's prestigious Peking University could not only shorten the recovery time for those infected, but even offer short-term immunity from the virus, researchers say. Sunney Xie, director of the university's Beijing Advanced Innovation Centre for Genomics, told AFP that the drug has been successful at the animal testing stage.’

Read here (The Star, May 19, 2020)

World Health Assembly: what is it, and what is the coronavirus inquiry proposal?

‘A key conference paper, already filed ahead of the assembly, and supported by 122 countries, including the members of the European Union and the African Group, the UK, Russia, Canada, Australia and New Zealand, calls for a systemic review of the world’s response to Covid-19. “Initiate, at the earliest appropriate moment, and in consultation with member states, a stepwise process of impartial, independent and comprehensive evaluation ... to review experience gained and lessons learned from the WHO-coordinated international health response to Covid-19.”

‘The draft motion does not mention China or Wuhan (the city where the virus was first detected) by name. But it urges the global health community to: “... identify the zoonotic source of the virus and the route of introduction to the human population, including the possible role of intermediate hosts, including through efforts such as scientific and collaborative field missions.”

And the paper argues the response to the pandemic must be global. The motion: “… calls for the universal, timely and equitable access to and fair distribution of all quality, safe, efficacious and affordable essential health technologies and products including their components and precursors required in the response to the Covid-19 pandemic as a global priority.”

Read here (The Guardian, May 18, 2020)

Download the 73rd WHA, Agenda Item 3, ‘Covid-19 response’ draft resolution here

Singapore study finds overweight Asians three times as likely to need intensive care

The study of 91 Covid-19 patients under the age of 60 also found those with a BMI of 25 or higher were six times more likely to need supplemental oxygen. Asians are known to have higher disease risks at lower body mass index thresholds, the researchers said, possibly because of body fat distribution.

Read here (South China Morning Post, May 15, 2020)