‘Until recently most people had never even heard of mRNA vaccines. Now scientists believe they may be the key to solving a wealth of health problems...
‘The theory behind the mRNA vaccine was pioneered by University of Pennsylvania scientists Katalin Karikó and Drew Weissman, who both recently received the 2021 Lasker Award, America's top biomedical research prize. Even in 2019, however, mainstream mRNA vaccines were believed to be at least five years away. The pandemic fast-forwarded this field of medicine by half a decade. Kathryn Whitehead, an associate professor of chemical engineering and biomedical engineering at Carnegie Mellon University, and a key collaborator of Weissman and Karikó admits, "there weren't many people in the mRNA therapeutics world who would have imagined 95% initial efficacy rates in this emergency scenario".
‘But now, the possibilities are seemingly endless. Or, as Blakney puts it: "Now it's like, OK, so it's worked for a viral glycoprotein, what other vaccines can we make with it? And what can we do beyond that?"...
‘All this raises the question: could mRNA therapeutics give us almost superhuman immunity? Already Covid-19 mRNA vaccines lead some people to produce very high levels of antibodies, able to neutralise several variants of Covid-19 at once.
‘There's also the potential to mix various mRNA vaccines together into a single health booster vaccine, which could ward off cancers and viruses at the same time. While it's just speculation at present, Fu says, "you could take a whole bunch of different flavours… a cocktail of mRNAs that make different proteins selective for your particular need." Both Moderna and Novavax already have combined Covid-19 and flu vaccines in development.’
Read here (BBC, Nov 23, 2021)
