Tuesday 16 March 2021

Covid-19: EU warns UK over vaccine exports

‘Ursula von der Leyen, president of the European Commission, has said that if Covid vaccine supplies in Europe do not improve, the EU "will reflect whether exports to countries who have higher vaccination rates than us are still proportionate". Post-Brexit disagreements between the EU and the UK have been heightened by the diplomatic row over the export of the vaccines.

‘The European Council president, Charles Michel, claimed last week that the UK had imposed an "outright ban" on the export of vaccines and their components - there is no ban though, and his claim was dismissed by the government as "completely false". But Mrs von der Leyen says the EU is still waiting for exports from the UK, and it wants reciprocity.’

Read here (BBC, Mar 17, 2021)

Malaysia PM Muhyiddin unveils RM20 billion economic stimulus package

‘Malaysian Prime Minister Muhyiddin Yassin announced a new economic stimulus package worth RM20 billion (US$4.8 billion) on Wednesday (Mar 17), one year after Malaysia first imposed a lockdown to curb the spread of COVID-19. This is the sixth package unveiled since the start of the COVID-19 pandemic.’

Read here (Channel News Asia, Mar 17, 2020)

Why the pandemic experts failed: We’re still thinking about pandemic data in the wrong ways

‘Not until early May, when the CDC published its own deeply inadequate data dashboard, did we realize the depth of its ignorance. And when the White House reproduced one of our charts, it confirmed our fears: The government was using our data. For months, the American government had no idea how many people were sick with COVID-19, how many were lying in hospitals, or how many had died. And the COVID Tracking Project at The Atlantic, started as a temporary volunteer effort, had become a de facto source of pandemic data for the United States.

‘After spending a year building one of the only U.S. pandemic-data sources, we have come to see the government’s initial failure here as the fault on which the entire catastrophe pivots. The government has made progress since May; it is finally able to track pandemic data. Yet some underlying failures remain unfixed. The same calamity could happen again.

‘Data might seem like an overly technical obsession, an oddly nerdy scapegoat on which to hang the deaths of half a million Americans. But data are how our leaders apprehend reality. In a sense, data are the federal government’s reality. As a gap opened between the data that leaders imagined should exist and the data that actually did exist, it swallowed the country’s pandemic planning and response.’

Read here (The Atlantic, Mar 16, 2021)

Monday 15 March 2021

Traveling to China just got easier—if you take a Chinese Covid-19 vaccine (Wall Street Journal, Mar 16, 2021)

‘After a year of barring entry by most foreign citizens, China’s government plans to ease restrictions for those who have been inoculated against Covid-19. The hitch for now: Only vaccines made in China will qualify.

‘Chinese embassies in the U.S., Italy, India, the Philippines and other locations say they will provide “visa facilitation” to foreign applicants who can certify that they have received a Chinese shot. To enter China, most travelers also still need to prove they have tested negative for Covid-19, obtain an antibody test, and quarantine upon arrival, according to statements Tuesday.’

Read here (Wall Street Journal, Mar 16, 2021)

Analysis: How for-profit health care worsened the pandemic

‘The U.S. remains the only one of the 25 wealthiest countries to not provide universal health care, and the health care system’s focus on profits and not health has cost Americans their lives. Despite having less than 5% of the world’s population, the U.S. has had 25% of the world’s confirmed cases and 20% of the deaths. Public Citizen’s new report demonstrates how:

  • Before the pandemic, approximately 87 million Americans were uninsured or underinsured. About one-third of COVID-19 deaths and 40% of infections were tied to a lack of insurance;
  • About half of Americans receive their health care through their employer. With more than 22 million Americans losing their job during the pandemic, millions have lost their health insurance;
  • Racial health disparities, including access to care, have led to disproportionate deaths in communities of color;
  • We have the highest rate of unmet need of any comparably wealthy country, with one-third of Americans reporting that they or a family member has avoided going to the doctor when sick or injured in the past year due to cost;
  • Americans are significantly more likely to die of chronic respiratory disease, cardiovascular disease, diabetes or cancer than people in comparably wealthy countries with universal health care systems; and
  • A lack of essential funding led to insufficient hospital capacity. The U.S. had only around half the hospital beds per capita of peer nations and far fewer than countries like Japan or Germany.’

Read here (Public Citizen, Mar 16, 2021)

BioNTech and Fosun Pharma form Covid-19 vaccine strategic alliance in China

  • BioNTech and Fosun Pharma will jointly conduct clinical trials of BNT162 in China, leveraging BioNTech’s proprietary mRNA vaccine technology and Fosun Pharma’s clinical development and commercialization capabilities in China
  • Fosun Pharma will commercialize the vaccine in China upon regulatory approval, with BioNTech retaining full rights to develop and commercialize the vaccine in the rest of the world
  • Fosun Pharma will pay BioNTech up to USD 135M (EUR 120M) in upfront and potential future investment and milestone payments; the two companies will share future gross profits from the sale of the vaccine in China

Read here (BioNTech press statement, Mar 16, 2021)

Moderna begins study of Covid-19 vaccine in kids

‘Moderna Inc has begun dosing patients in a mid-to-late stage study of its COVID-19 vaccine, mRNA-1273, in children aged six months to less than 12 years, the company said on Tuesday (Mar 16). The study will assess the safety and effectiveness of two doses of mRNA-1273 given 28 days apart and intends to enrol about 6,750 children in the United States and Canada.’

Read here (Channel News Asia, Mar 16, 2021)

Molnupiravir: A new hope for prevention and treatment of Covid-19 and other dangerous viruses

‘The positive results of Molnupiravir represent an emerging hope for more Covid-19 therapies to come. Its oral administration indicates a potential drug that could come before hospitalization and perhaps even prevent severe symptoms. Were a pill-based treatment for Covid-19 available, many lives would be easily saved and many hospital beds could be opened for those who need them. 

‘In addition to its reduction of Covid-19 transmission, Molnupiravir is likely to be useful against influenza, ebola, and a large swath of other viruses as well. Its development appears to be a major advancement in virus control and should be active against Covid-19 variants and variants of other viruses. However, we caution Molnupiravir should be administered in conjunction with other therapies to avoid viruses rapidly developing resistance, which all these viruses are well-equipped to do. 

‘Though, as these results are preliminary, we eagerly await the full release of the phase two data and the drug’s eventual full trial outcomes. This could be a real winner.’

Read here (Forbes, Mar 16, 2021)

What’s the best Covid vaccine? Why it’s not so simple: Quick take on seven issues

‘A range of vaccines with different efficacy results now has given rise to worries that some people may refuse the shot on offer in hopes of getting a “better” one later. In reality, comparing efficacy numbers isn’t necessarily the best way to measure a vaccine’s value. And as suppliers struggle to meet global demand, experts say the best vaccine for you is probably whichever one you can get now.’

Bloomberg's Quick Take answers seven questions:

  1. What does efficacy mean?
  2. What efficacies are being reported?
  3. Are the numbers reliable?
  4. Why isn’t efficacy all that counts?
  5. So numbers may be misleading?
  6. What matters beyond the efficacy number?
  7. What’s the bottom line?

Read here (Bloomberg, Mar 15, 2021)

Covid-19: Only 0.11% of 300,000 vaccine recipients so far are govt officials, elected reps, says Khairy

‘Only 0.11% of the 300,000 Covid-19 vaccine recipients in Malaysia so far are government officials and elected representatives, says Khairy Jamaluddin. The coordinating minister of the National Covid-19 Immunisation Programme said the 0.11% constituted 302 people, while the rest are mostly healthcare workers.

“Based on the breakdown of the 292,104 people who have been vaccinated as of March 13, they comprise 23.86% nurses, 22.23% doctors and 23.4% other healthcare workers such as medical assistants, X-ray specialists and ambulance drivers. Another 21.33% are frontline workers from the armed forces, police, civil defence force, Rela (people’s volunteer corps) and Customs officers, among others. Another 5.62% are dentists while 3.45% are pharmacists.”

Read here (The Star, Mar 15, 2021)

UK clinical trial confirms SaNOtize’s breakthrough treatment for Covid-19

  • Patients with a self-administered nasal spray application found to have reduced SARS-CoV-2 log viral load by more than 95% in infected participants within 24 hours of treatment, and by more than 99% in 72 hours
  • Trial concluded that treatment accelerated clearance of SARS-CoV-2 by a factor of 16-fold versus a placebo
  • Randomized, double-blind, placebo-controlled trial evaluated 79 confirmed cases of COVID-19, the majority heavily-infected with the UK variant
  • No adverse events were recorded in the group
  • Submission for Emergency Use in the UK and Canada for the treatment and prevention of COVID-19 is planned immediately

Read here (Business Wire, Mar 15, 2021)

Sunday 14 March 2021

Mark Zuckerberg announces Facebook's plans to help get people vaccinated against Covid-19

‘Today we're launching a global campaign to help bring 50 million people a step closer to getting Covid-19 vaccines. 

‘We've already connected over 2 billion people to authoritative Covid-19 information. Now that many countries are moving towards vaccinations for all adults, we're working on tools to make it easier for everyone to get vaccinated as well. 

‘First, we're launching a tool that shows you when and where you can get vaccinated and gives you a link to make an appointment. This will be in the Covid Information Center, which we'll show people right in their News Feed. We've already seen people use Facebook to find vaccination appointments, so this should enable millions more people to do the same.

‘Second, we're bringing the Covid Information Center to Instagram, and we'll show it to people prominently there too. 

‘Third, we're working with health authorities and governments to expand their WhatsApp chatbots to help people register for vaccines. More than 3 billion messages related to Covid have already been sent by governments, non-profits and international organizations to citizens through official WhatsApp chatbots, so this update will help with the vaccination effort as well.’

Read here (Facebook, Mar 15, 2020)

Coronavirus vaccine: China can meet demand ‘at home and abroad’

‘China is giving priority to coronavirus inoculation campaigns at home but will still be able to honour promises of vaccines for other countries, according to a senior official in charge of producing the doses. Tian Yulong, chief engineer with the Ministry of Industry and Information Technology, said domestic needs had taken precedence but with expanded production of four approved vaccines, he was confident that China would be able to meet the combined demand of domestic inoculation, foreign aid and exports.

“We have successfully met demand to give out more than 64 million doses at home. We have also had good feedback about our exports and foreign aid,” Tian said in Beijing on Monday.

Read here (South China Morning Post, Mar 15, 2021)

Khairy set to be first recipient of Sinovac Covid-19 vaccine this Thursday

‘Malaysia will start using the Sinovac Covid-19 vaccine this Thursday, with the Coordinating Minister for the National Covid-19 Immunisation Programme, Khairy Jamaluddin, becoming the first recipient of the Chinese-produced vaccine.

‘Announcing the matter in a press conference on the development of the National Covid-19 Immunisation Programme here today, Khairy said that he would receive the Sinovac vaccine at the Rembau Hospital, Negri Sembilan.’

Read here (Malay Mail, Mar 15, 2021)

Khairy: No charges for Covid-19 vaccination at private facilities

‘Individuals who get an appointment for Covid-19 vaccine injection at private hospitals or clinics involved in the National Covid-19 Immunisation Programme will not have to pay any charges, said National Covid-19 Immunisation Programme Coordinating Minister Khairy Jamaluddin. 

“The charges are borne by the government,” he told a press conference on developments involving the progamme here today. 

‘Elaborating, Khairy, who is Minister of Science, Technology and Innovation, said Covid-19 vaccination centres (PPV) are set based on the address registered by the individual through the MySejahtera application. 

“If the vaccination centre near the address given is a private hospital, then they will go to that private hospital. Everything is based on location because we want to facilitate this immunisation programme,” he said.

Read here (Malay Mail, Mar 15, 2021)

Saturday 13 March 2021

‘A can of worms’: Experts weigh in on the vaccine passport debate

‘From Israel to Iceland, several governments around the world are adopting so-called coronavirus vaccine passports as they bid to safely reopen borders, unfreeze economies from costly lockdowns and restore a semblance of normality to social life. 

‘Supporters of the vaguely-defined certificates argue they have a critical role to play in ending restrictions imposed to curtail the spread of the pandemic, at least in countries with widescale access to vaccines.

‘But sceptics say they present insurmountable scientific, legal, and ethical issues – at least for now – and should not be used either within individual countries or as a tool to unlock international travel. As the debate continues, Al Jazeera asked five United Kingdom-based experts for their opinions.’

Read here (Aljazeera, Mar 14, 2021)

After a year of MCO, recovery is in sight

‘On March 18, 2020, the first Movement Control Order (MCO) was imposed and there was much uncertainty among the public and business community over what would happen next. One year on, the SARS-CoV-2 virus has taken 1,177 lives and infected 314,989 people in the country (as at March 10). Despite the grim circumstances, many see light at the end of the tunnel as Malaysia rolls out its National Covid-19 Immunisation Programme (NCIP).

‘Speaking to experts, we identify three main areas that beckons attention — healthcare, economy and last but not least politics. Covid-19 is still raging on globally, and the challenge is to vaccinate the community as quickly as possible so as to not allow the more transmissible variants to get a foothold in the community. Meanwhile, vaccine effectiveness is seen as one key driver for economic recovery. When that has effectively been executed, the focus should be on repairing the damage that has been caused by the pandemic.

‘Many also believe that political stability is one challenge Malaysia will face. There is a need to exit from the emergency rule and for the country to be given a clear mandate from a stable government.

‘In the accompanying stories, we take a look at the winners and losers in the post-pandemic era. Will pandemic winners such as the glove and technology players continue to prosper? Will the tourism, retail, hospitality and manufacturing industries as well as small and medium enterprises move away from the dire conditions brought on by Covid-19 anytime soon?

‘Nonetheless, it has been a fruitful year for local equities since the pandemic outbreak, with healthcare and technology stocks being the top gainers. What can we expect for the rest of the year after stock prices for most sectors rebounded significantly from their lows last year? We speak to heads of research to find out what they think about the market direction.’ 

Get the full story in this week’s issue of The Edge Malaysia.

Read here (The Edge, Mar 13, 2021)

'Covid is taking over': Brazil plunges into deadliest chapter of its epidemic

‘[André] Machado saw several explanations for the torrent of cases he and other doctors are now seeing, including political mismanagement and the slackening of social distancing measures, principally among the young. In recent months such containment efforts have largely collapsed, with schools and businesses reopening and Bolsonaro’s tourism minister even urging citizens to start holidaying again.

‘But the doctor suspected a third, more troubling element was also at work: an enigmatic and apparently more contagious variant called P1 that is thought to have emerged in the Amazon region in late 2020 but is now circulating across Brazil, including in the southern state of Rio Grande do Sul, where Machado works.’

Read here (The Guardian, Mar 13, 2021)

Friday 12 March 2021

WHO approves J&J's COVID-19 vaccine for emergency listing

‘The World Health Organization on Friday (Mar 12) approved the emergency listing of Johnson & Johnson's COVID-19 vaccine, giving its seal of approval to expedite use especially in countries with weaker regulatory agencies. It is the third COVID-19 vaccine after the two-shot regimens of Pfizer/BioNTech and AstraZeneca to receive backing from the WHO, and the first requiring just a single injection.’

Read here (Channel News Asia, Mar 13, 2021)

Coronavirus economic relief: Are we getting value for the money thrown at the pandemic? - Andrew Sheng

‘The US fiscal deficit rose from 6.4 per cent of GDP in 2019 to 17.5 per cent in 2020. This is an increase of 11.1 percentage points in GDP fiscal support to defend a decline of 5.8 percentage points in GDP growth...

‘The Biden administration is betting that the largest US stimulus package since World War II will restore American competitiveness and heal the nation. But much of this is not funded by domestic savings, such as taxing the rich, but by borrowing on the US dollar. 

‘The rest of the world will not fund the dollar forever, certainly not at near-zero interest rates. And if interest rates rise, the fiscal costs would be substantially higher. So bet on the Fed doing more to keep rates low. The truth of US debt is that it is not debt, but the rest of the world’s equity. America is the world’s too-big-to-fail borrower. If Biden fails, we will lose.’

Read here (South China Morning Post, Mar 13, 2021)

US and allies (India, Australia and Japan) promise one billion jabs for South East Asia

‘The leaders of the US, Australia, India and Japan have agreed to deliver one billion doses of coronavirus vaccine to much of Asia by the end of 2022. The joint commitment was made following the first leaders' meeting of the so-called Quad - a group formed in 2007. The vaccines - expected to be the single-dose Johnson & Johnson product - are set to be manufactured in India.’

Read here (BBC, Mar 13, 2021)

Defying rules, anti-vaccine accounts thrive on social media

‘Efforts to crack down on vaccine misinformation now, though, are generating cries of censorship and prompting some posters to adopt sneaky tactics to avoid the axe. “It’s a hard situation because we have let this go for so long,” said Jeanine Guidry, an assistant professor at Virginia Commonwealth University who studies social media and health information. “People using social media have really been able to share what they want for nearly a decade.”

‘The Associated Press identified more than a dozen Facebook pages and Instagram accounts, collectively boasting millions of followers, that have made false claims about the COVID-19 vaccine or discouraged people from taking it. Some of these pages have existed for years. Of more than 15 pages identified by NewsGuard, a technology company that analyzes the credibility of websites, roughly half remain active on Facebook, the AP found.’

Read here (APNews, Mar 12, 2021)

On the psychology of the conspiracy denier

‘We know, without question, that politicians lie and hide their connections and that corporations routinely display utter contempt for moral norms – that corruption surrounds us. We know that revolving doors between the corporate and political spheres, the lobbying system, corrupt regulators, the media and judiciary mean that wrongdoing is practically never brought to any semblance of genuine justice. We know that the press makes noise about these matters occasionally but never pursues them with true 

‘So exactly what is it that conspiracy deniers refuse to acknowledge with such fervour, righteousness and condescension? Why, against all the evidence, do they sneeringly and contemptuously defend the crumbling illusion that ‘the great and good’ are up there somewhere, have everything in hand, have only our best interests at heart, and are scrupulous, wise and sincere? That the press serves the people and truth rather than the crooks? That injustice after injustice result from mistakes and oversights, and never from that dread word: conspiracy?’

\Read here (OffGuardian, Mar 12, 2021)

Has the pandemic changed public attitudes about science?

Has the pandemic changed public attitudes about science?

‘These results [of surveys] show clear evidence that scientific and medical experts are enjoying a surge in public support on top of their already high levels of public trust. With some variation from country to country and among different groups within countries, the overall picture of pandemic-era public opinion is a success story for science’s status amidst this crisis.

‘The impacts from COVID-19 will be with us for years to come. However, questions remain as to how this re-affirmed trust might be built on. How can the increased levels of trust in science be maintained? What proactive steps can scientific institutions take to ensure that they continue earning this trust? How might support for science be used to focus further public engagement on other global challenges such as climate change? Framed in these terms, moves such as the UK government’s decision to invest in a new research agency (ARIA), may indicate more widespread changes in the direction of science policy.

‘At a structural level, the public faith in science’s trustworthiness and value can also be ‘future proofed’ through ongoing initiatives to make scientific research open and transparent, enhanced efforts to ensure a more diverse and inclusive scientific workforce and other efforts to improve science from within. Initiatives working in this direction include increased adoption of open science policies by research funders and global public policy that promotes more socially responsible research and innovation. Indeed, this moment of strong public support may be the perfect opportunity for long-needed structural reforms to make research more socially responsible and sustainable. In other words, it’s time to fix the roof while the sun is shining!’

Read here (LSE Blog, Mar 12, 2021)

Thursday 11 March 2021

Fake news law is government’s attempt to silence voice of every citizen — National Union of Journalists Peninsular Malaysia

‘The National Union of Journalists Peninsular Malaysia (NUJM) expresses its grave concern over the  government’s move to gazette an ordinance purportedly to combat “fake news” relating to Covid-19 or  the Emergency proclamation. NUJ Malaysia is not agreeing to this kind of step backwards action taken as it seems like the ruling  government is trying to silent the voice of every citizen regardless of their race, religion or various  background.

‘We called on the government’s plan of setting up the Media Council to be revived and accelerate just to tackle any issues regarding to media practitioners especially journalists who are in the frontline. The union is in the view that Media Council can also be in charge of looking into the alleged fake news crime committed instead of the government having to gazette new laws to tackles this. This in turn will  display transparency over the alleged crime committed.’

Read here (Malay Mail, Mar 12, 2021)

There is no one pandemic anniversary

‘Disaster anniversaries are powerful in part because they’re communal. The bomb went off in an instant. The tornado tore through town in an afternoon. The earthquake rocked the whole region at once. The pandemic, though, did not come to everyone on the same day, or even in the same month, and nor will its anniversary. In this way, as in so many others, this is not an ordinary disaster.

‘For each of the country’s more than 526,000 dead, nine people grieve. Hundreds of thousands have spent time in the ICU, an experience that can bring its own unique trauma. And then there are the smaller losses, the ones that did not threaten lives but still changed them. Today is the day I missed my mother’s funeral. The day I would have gone to prom. Met my grandson. Gotten married.’

Read here (The Atlantic, Mar 12, 2021)

Waiver from certain provisions of the TRIPS agreement for the prevention, containment and treatment of Covid-19: A compilation of resources

‘On 2nd October India and South Africa made a joint submission (IP/C/W/669) to the World Trade Organization seeking a waiver from certain provisions of the TRIPS Agreement (patents, trade secrets, copyright and industrial designs) in relation to the containment, prevention and treatment of COVID-19. This proposal is now co-sponsored by 57 developing countries including the Africa Group and the Least Developed Country Group and has received global support from most of the other developing countries and the international community. Technical Briefing by Médecins Sans Frontières (MSF) as well as this video provides information on the importance of the waiver from TRIPS obligations.

‘Below is a list of interventions by the co-sponsors, statements and op-eds supporting the waiver proposal and news reports about the proposal...‘

Read here (Third World Network, ongoing work)

Strong support for TRIPS waiver amidst opposition by Big Pharma

‘More than 100 countries have upped the stakes for text-based negotiations on the TRIPS waiver proposal that seeks to temporarily suspend certain provisions of the WTO’s TRIPS Agreement in combating the COVID-19 pandemic, amidst attempts by Big Pharma to kill the waiver proposal, said people familiar with the development.

‘Ahead of the WTO’s TRIPS Council meeting on 10 March, the representatives of Big Pharma wrote to President Joseph Biden that the “US government has stood alongside other governments, including the European Union, United Kingdom, Japan, Canada, Switzerland, Brazil, and Norway to oppose this waiver.”

“We urge your administration to maintain this longstanding support for innovation and American jobs by continuing to oppose the TRIPS waiver,” said the CEOs of Pfizer, AstraZeneca, PhRMA (Pharmaceutical Research and Manufacturers of America), Eli Lilly, Bristol Myers Squibb, Gilead Sciences, Merck, Sanofi, Takeda Pharmaceuticals, Novartis, Abbvie, Bayer AG, Amgen Inc, and Biogen among others.

‘The CEOs of these companies, who constitute the powerful Big Pharma, decried the waiver proposal, saying that “in requesting the waiver, India and South Africa argued without evidence that the intellectual property is hindering the global response to the pandemic and that the waiver would help scale up research, development, manufacturing and supply of needed products.”

Read here (Third World Network, Mar 12, 2021)

Bar council slams ‘disturbing’ new fake news law

‘The latest clampdown on fake news comes as a shock for lawyers, with Bar Council president Salim Bashir describing the powers the government has given itself to clamp down on such news as “disturbing”. Speaking to FMT, he also said the “imprecise definition” of fake news that includes anything related to Covid-19 and the proclamation of emergency, was “worrisome.”

‘Gazetted today, the Emergency (Essential Powers) (No. 2) Ordinance 2021 penalises those who create, publish or distribute fake news with a fine of up to RM100,000, a jail term of up to three years or both. If they fail to apologise after being ordered to do so by the court, they can be fined an additional RM50,000, and those who pay to “create” such news can be fined up to RM500,000. All fines come with jail terms as well.’

Read here (Free Malaysia Today, Mar 12, 2021)

Home Ground: Ethical issues in Covid-19 vaccine roll-outs

‘A principled and pragmatic approach to securing and allocating Covid-19 vaccines works best... ‘Every vaccination programme carries with it ethical concerns over, among other things, safety, efficacy and how to distribute and allocate the vaccine when there are limited supplies...

‘A vaccine programme in the middle of a global pandemic is even trickier. On the one hand, speedy access to the vaccine can make the difference between life and death. On the other hand, the vaccines for Covid-19 are new and relatively untested: The world is learning of side effects as millions more get jabbed; and while we know the short-term efficacy, no one knows how long the protection lasts.

‘As Prof Lim said at the webinar, rolling out vaccination in the middle of a public health emergency is like chasing after a moving target. This requires constant monitoring and updating of rules and plans.’

This account also discusses, in the Singapore context: (1) The race to get hold of supplies (2) Who gets jabbed first and why (3) Why giving a choice of vaccine is not a good idea.

Read here (Straits Times, Mar 12, 2021)

Covid: Asthma drug 'speeds up recovery at home'

‘A cheap drug, commonly used to treat asthma, can help people at home recover more quickly from Covid-19, a UK trial has found.

‘Two puffs of budesonide twice a day could benefit many over-50s with early symptoms around the world, said the University of Oxford research team.’

Read here (BBC, Mar 12, 2021)

Nobel prize economists Joseph Stiglitz and Michael Spence call for vaccine equity and debt relief

‘Nobel Prize-winning economists Joseph Stiglitz and Michael Spence are spearheading calls for urgent action to help poorer countries recover from the economic ravages of the coronavirus pandemic, including measures to advance vaccine equity, debt relief, and bolstering fiscal resources for cash-strapped nations.

‘The proposals were outlined in a new interim report released on Thursday – the one-year anniversary of the global pandemic – by the Institute for New Economic Thinking’s Commission on Global Economic Transformation, co-chaired by Stiglitz and Spence.‘

Read here (Aljazeera, Mar 11, 2021)\

The pandemic and the economic crisis: A global agenda for urgent action

Read full text here (Institute for New Economic Thinking, March, 2021)

Wednesday 10 March 2021

The catch to ‘free’ Covid-19 vaccination by private hospitals – P Gunasegaram

‘I read with great interest the story that private hospitals are prepared to help the government inoculate people against Covid-19 – and here’s the curious part – by disseminating the vaccine without charge. Yes, you read that right. But if the government is not careful, it may end up giving private hospitals windfall gains of over half a billion ringgit, as we shall show.

‘It was reported that this will be for vaccines procured by the government, with private hospitals appointed as implementers of the free jabs...’

Read here (The Vibes, March 11, 2021)

How the US pandemic response went wrong — and what went right — during a year of Covid

‘Among the biggest shocks was that the U.S. fared worse than most other countries, with more than 29 million cases and nearly 530,000 deaths as of this writing. “We absolutely can’t say that we had the most robust response to the pandemic, up till this point, because we have had a higher death rate per capita than so many other places,” says Monica Gandhi, a professor of medicine at the University of California, San Francisco.

‘As the country raced to react to this new and terrifying scourge, mistakes were made that together cost hundreds of thousands of lives. Yet the tireless efforts of health care workers, along with an unprecedented vaccine push, have saved countless others. Scientific American interviewed scientists and public health experts about the biggest mistakes in the U.S.’s response, some of the key successes and the lingering questions that still need to be answered.’

Read here (Scientific American, Mar 11, 2021)

Pandemic: One year - A round-up by Associated Press

On March 11, 2020, the World Health Organization declared COVID-19 a pandemic. The Associated Press explores the ensuing year of loss, perseverance and hope:

  • Faith leaders' year of pandemic: grief, solace, resilience
  • As pandemic enters 2nd year, voices of resilience emerge
  • AP-NORC poll: People of color bear COVID-19′s economic brunt
  • ‘It’s exhausting.’ A year of distance learning wears thin
  • As pandemic enters 2nd year, voices of resilience emerge
  • AP-NORC poll: People of color bear COVID-19′s economic brunt
  • Only on AP: Italian doctor a chronic COVID patient
  • One year on: stars’ COVID-19 experiences
  • March 11, 2020: The night sports, as we knew them, ended
  • AP-NORC poll: 1 in 5 in US lost someone close in pandemic
  • A year on, WHO still struggling to manage pandemic response
  • Why the pandemic left long-term scars on global job market
  • After pandemic year, weary world looks back — and forward
  • A homebound year has meant rethinking our rooms, belongings
  • And more...

Read here (Associated Press, Mar 11, 2021)

A year on, WHO still struggling to manage pandemic response

‘When the World Health Organization declared the coronavirus a pandemic one year ago Thursday, it did so only after weeks of resisting the term and maintaining that the highly infectious virus could still be stopped. A year later, the U.N. agency is still struggling to keep on top of the evolving science of COVID-19, to persuade countries to abandon their nationalistic tendencies and help get vaccines where they’re needed most.

‘The agency made some costly missteps along the way: It advised people against wearing masks for months and asserted that COVID-19 wasn’t widely spread in the air. It also declined to publicly call out countries — particularly China — for mistakes that senior WHO officials grumbled about privately. That created some tricky politics that challenged WHO’s credibility and wedged it between two world powers, setting off vociferous Trump administration criticism that the agency is only now emerging from.’

Read here (APNews, Mar 11, 2021)

Canadian-pharma solution to aid worldwide Covid vaccine access

‘Despite the optimism [over vaccines], there remains a missing space for people in low-income nations who desperately need these vaccines and who may wait too long. As the World Health Organization (WHO) noted in a recent media conference, the global vaccine stocks remain critically short of supply at this time.

‘Biolyse Pharma an Ontario based manufacturer of sterile injectable medicine hopes to be part of a solution. Biolyse has the potential of producing up to twenty million doses per year. In order to do so, the company will need access to the drug master file of an already approved vaccine which is generally patent protected. The Canadian Access to Medicines Regime (CAMR) relating to emergency-patent transfer may permit the company to achieve its objective.  

‘CAMR is the Canadian enabling legislation that reflects the Agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPS), a protocol between all the member nations of the World Trade Organisation. Under CAMR, there is an emergency provision for the federal government to waive patent rights, allowing other generic-producing companies to start expedited production of critical preventative or curative drugs. Canada therefore has a mechanism in place to allow drug companies to a compulsory license from a patent holder.’

Read here (Newswire, Mar 11, 2021)

Tuesday 9 March 2021

Khairy welcomes private sector procuring approved Covid-19 vaccines

“With regards to the purchase of vaccines by the private sector, as I have mentioned yesterday, most of the vaccine manufacturers only carry out negotiations with governments,” Khairy responded to Najib in a comment on his Facebook post...

“But if there are private parties who are able to carry out negotiations with vaccine manufacturers, especially those that have received approval from the NPRA (National Pharmaceutical Regulatory Agency) (Pfizer, AstraZeneca, and Sinovac), please do so. I really welcome it,” added the science, technology and innovation minister. 

‘Previously, Malaysian-based pharmaceutical company Pharmaniaga Bhd announced that it planned to sell some of its Sinovac vaccine doses to the private sector. Pharmaniaga is undertaking the fill-and-finish processing of Sinovac’s vaccine. Solution Biologics, the distributor of Chinese CanSino’s vaccine, has also expressed plans to supply private health care providers with the vaccine, on top of selling 3.5 million doses to the Malaysian government.’ 

Read here (Code Blue, Mar 10, 2021)

Coronavirus and the money behind vaccines

The FT explains how the vaccine market works – including the cost of a vaccine and the vaccine development process – and the impact of the Covid-19 pandemic. This short documentary features global experts including Bill Gates, the CEOs of Moderna and Gavi, and the lead scientist behind the Oxford/AstraZeneca vaccine. 

View here (Financial Times, Youtube, Mar 10, 2021)

WTO DG meets Big Pharma and opts for voluntary licenses

‘The World Trade Organization Director-General Ms Ngozi Okonjo-Iweala said on 9 March that she fully supports the TRIPS waiver, insisting that she has conveyed to Big Pharma that they need to understand the “practicalities and sentiments” behind the demand for the waiver, said people familiar with the development.

‘Yet, she maintained that the TRIPS waiver may not be able to address the issue of ramping up production of vaccines to combat COVID-19 due to difficult manufacturing conditions that need to be complied with for producing vaccines, said people familiar with her remarks.

‘Her continued ambivalent positions seem to have undermined the move towards text-based negotiations on the TRIPS waiver, said people familiar with the development.’

Read here (Third World Network, Mar 10, 2021)

Malaysia vaccinates one third of frontliners within fortnight

‘A third of 500,000 frontliners have received their first dose of the Covid-19 vaccine, some three weeks before the targeted vaccination completion by March 31. As of March 8, a total of 166,363 frontliners have received their first dose of the coronavirus vaccine, achieving 33.3 per cent of the national Covid-19 immunisation programme’s Phase One target in 13 days after the vaccines were rolled out from February 24.

‘If the current pace continues, the government will need another 26 days to administer at least the first dose to all 500,000 frontline workers, just slightly missing the March 31 target by three days.’ 

Read here (Code Blue, Mar 9, 2021)

Prioritise pandemic relief, recovery: No time for debt buybacks

‘Developing country governments are being wrongly advised to use their modest fiscal resources to pay down accumulated debt instead of strengthening pandemic relief and recovery. Thus, debt phobia risks deepening and extending COVID-19 recessions by prioritising buybacks...

‘With ‘collective action’ complications affecting negotiations, and the greater number and variety of heavily indebted countries and creditors, equitable debt buybacks are impossible to negotiate. Worse, prioritising buybacks means rejecting former debt hawk Reinhart’s current pragmatic advice to “First fight the war, then figure out how to pay for it”.

‘The urgent priority is for fiscal resources to strengthen relief, recovery and reform measures. Prioritising debt buybacks, instead of urgently augmenting fiscal resources, may thus contribute to another “lost decade” or worse.’

Read here (IPS News, March 9, 2021)

Coronavirus: How can travel be more sustainable post-pandemic?

"The coronavirus pandemic has been a global shock moment that has led to a rethink in the tourism industry, which is so accustomed to success," said Martin Balas of the Center for Sustainable Tourism (ZENAT) at the Eberswalde University for Sustainable Development.

‘Issues such as climate protection and overtourism, which were already major challenges for tourism before COVID, have now come into even sharper focus, Balas told DW. The German Travel Association (DRV) also sees the coronavirus pandemic as an opportunity for more sustainability in the industry.

"Sustainable travel is a trend that has been around for years, and the travel industry has already responded to it and will continue to do so in the future," said Ellen Madeker of DRV. Several large travel companies are preparing awareness campaigns designed to increase travelers' awareness of the impacts of travel.’

Read here (DW, Mar 9, 2021)

Monday 8 March 2021

The new normal (Phase 2)

‘So, we’re almost a year into the “New Normal” (a/k/a “pathologized totalitarianism”) and things are still looking … well, pretty totalitarian. Most of Western Europe is still in “lockdown,” or “under curfew,” or in some other state of “health emergency.” Police are fining and arresting people for “being outdoors without a valid reason.”  Protest is still banned. Dissent is still censored.

‘The official propaganda is relentless. Governments are ruling by edict, subjecting people to an ever-changing series of increasingly absurd restrictions of the most fundamental aspects of everyday life.

‘And now, the campaign to “vaccinate” the entirety of humanity against a virus that causes mild to moderate flu-like symptoms or, more commonly, no symptoms at all, in over 95% of those infected, and that over 99% of the infected survive (and that has no real effect on age-adjusted death rates, and the mortality profile of which is more or less identical to the normal mortality profile) is being waged with literally religious fervor.

“Vaccine passports” (which are definitely creepy, but which bear no resemblance to Aryan Ancestry Certificates, or any other fascistic apartheid-type documents, so don’t even think about making such a comparison!) are in the pipeline in a number of countries. They have already been rolled out in Israel.’

Read here (OffGuardian, Mar 9, 2020)

Can vaccinated people transmit COVID-19? The answer will be key to ending the pandemic

‘There’s been positive news about how effective the vaccines might be in preventing transmission—but as several experts note, some studies that have been made public so far are inconclusive. Until we have a better answer on transmission, social distancing, hand hygiene, testing, and mask wearing will remain important in the fight to limit and eventually end the pandemic.

‘A recent, unpublished Israeli study showed a nearly 90 percent reduction in infections among the vaccinated population. Wired magazine writer Megan Molteni noted that the media framing of the study may have been overly optimistic. While the headlines about this unpublished study were wildly enthusiastic, the reality is more nuanced.  “Israel finds BioNTech/Pfizer vaccine reduced virus transmission,” read one headline. But Eric Topol, a professor of molecular medicine at Scripps Research, told Wired he was skeptical about drawing any conclusions about the extent to which the Pfizer vaccine cut transmission rates. He told the magazine that to accurately study asymptomatic transmission, both vaccinated and unvaccinated people should be regularly tested. “The testing rates were such a hodgepodge, I don’t know you can make any conclusions about how much the vaccine cut transmission in Israel, let alone assigning a number as concrete as 89.4 percent,” he told Molteni.’

Read here (Bulletin of the Atomic Scientists, March 9, 2021)

Sg Buloh Hospital: Lessons from frontline of country's main Covid-19 centre

‘Sungai Buloh Hospital (HSB) had been at the forefront of the fight against the Covid-19 pandemic since the day the virus was detected on our shores. Serving as the main dedicated Covid-19 centre, it has treated nearly 50,000 positive patients to date.

‘While the hospital had been successful in helping the country battle the outbreak, little is known about what has been happening behind the scenes, especially the struggles faced by frontliners who had dedicated their lives for the sake of their patients.

‘Malaysiakini spoke to HSB director Dr Kuldip Kaur (above) in an exclusive interview recently, during which she revealed some of the biggest challenges they faced.’

Read here (Malaysiakini, Mar 9, 2021)

Most Covid-19 hospitalisations due to four conditions

‘Based on this data, the model calculated the percentage of COVID-19 hospitalizations that could have been prevented without these four underlying conditions. Results were published in the Journal of the American Heart Association on February 25, 2021. The researchers estimated that more than 900,000 COVID-19 hospitalizations occurred through November 2020. Based on their model, 30% of these hospitalizations were attributable to obesity, 26% to hypertension, 21% to diabetes, and 12% to heart failure. These people would still have been infected with COVID-19, but likely would not have been sick enough to need hospitalization.

‘More than one of these conditions are often present in the same person. The model also estimated hospitalizations due to different combinations. The numbers weren’t simply additive. In total, 64% of the hospitalizations might have been prevented if not for the four conditions. The model suggested that COVID-19 hospitalizations due to these conditions varied by age. Older adults with diabetes, heart failure, or hypertension were more likely to be hospitalized than younger people with the same condition. However, obesity affected COVID-19 hospitalization risk similarly across age groups.’

Read here (NIH, Mar 9, 2021)

The differences between the vaccines matter

‘It’s certainly true that all three of the FDA-authorized vaccines are very good—amazing, even—at protecting people’s health. No one should refrain from seeking vaccination on the theory that any might be second-rate. But it’s also true that the COVID-19 vaccines aren’t all the same: Some are more effective than others at preventing illness, for example; some cause fewer adverse reactions; some are more convenient; some were made using more familiar methods and technologies. As for the claim that the vaccines have proved perfectly and equally effective at preventing hospitalization and death? It’s just not right.

‘These differences among the options could matter quite a bit, in different ways to different people, and they should not be minimized or covered over. Especially not now: Vaccine supplies in the U.S. will soon surpass demand, even as more contagious viral variants spread throughout the country. In the meantime, governors are revoking their rules on face masks, or taking other steps to loosen their restrictions. It’s tempting to believe that a simple, decisive message—even one that verges on hype—is what’s most needed at this crucial moment. But if the message could be wrong, that has consequences.’

Read here (The Atlantic, Mar 8, 2021)

Unlocking the mysteries of Long Covid

‘A growing number of clinicians are on an urgent quest to find treatments for a frighteningly pervasive problem. They’ve had surprising early success...

‘The unlucky remainder—more than 90 percent of the patients the center has seen—was a puzzling group “where we couldn’t see what was wrong,” Chen said. These tended to be the patients who had originally had mild to moderate symptoms. They were overwhelmingly women, even though men are typically hit harder by acute COVID‑19. (Acute COVID‑19 refers to the distinct period of infection during which the immune system fights off the virus; the acute phase can range from mild to severe.) And they tended to be young, between the ages of 20 and 50—not an age group that, doctors had thought, suffered the worst effects of the disease. Most of the patients were white and relatively well-off, raising concern among clinicians that many people of color with ongoing symptoms were not getting the care they needed.

‘These patients’ tests usually showed nothing obviously the matter with them. “Everything was coming back negative,” says Dayna McCarthy, a rehabilitation-medicine physician and a lead clinician at the center. “So of course Western medicine wants to say, ‘You’re fine.’ ”

‘But the patients were self-evidently not fine. An international survey by Patient-Led Research for COVID‑19, one of various groups drawing attention to persisting problems, asked nearly 3,800 patients with ongoing illness to describe their symptoms. A significant number—85.9 percent—reported having relapses in the months after their initial infection, usually triggered by mental or physical exertion. (Not all patients in this group had confirmed cases of COVID‑19, given that tests were hard to come by last March and April.) Many patients were experiencing severe fatigue and brain fog. Other patients suffered from chest tightness and tachycardia—a condition in which the heart beats more than 100 times a minute—when they stood up or walked. Others had diarrhea and lost their appetite; some had terrible bone pain. Nearly a quarter said they were still unable to work; many had gone on disability or taken medical leave. Patient groups of COVID‑19 “long-haulers” were springing up on Facebook and elsewhere online, where people shared data and compared notes about what they began to call “long COVID.”’

Read here (The Atlantic, Mar 8, 2021)

Late-stage pandemic is messing with your brain

‘This is the fog of late pandemic, and it is brutal. In the spring, we joked about the Before Times, but they were still within reach, easily accessible in our shorter-term memories. In the summer and fall, with restrictions loosening and temperatures rising, we were able to replicate some of what life used to be like, at least in an adulterated form: outdoor drinks, a day at the beach. But now, in the cold, dark, featureless middle of our pandemic winter, we can neither remember what life was like before nor imagine what it’ll be like after.

‘To some degree, this is a natural adaptation. The sunniest optimist would point out that all this forgetting is evidence of the resilience of our species. Humans forget a great deal of what happens to us, and we tend to do it pretty quickly—after the first 24 hours or so. “Our brains are very good at learning different things and forgetting the things that are not a priority,” Tina Franklin, a neuroscientist at Georgia Tech, told me. As the pandemic has taught us new habits and made old ones obsolete, our brains have essentially put actions like taking the bus and going to restaurants in deep storage, and placed social distancing and coughing into our elbows near the front of the closet. When our habits change back, presumably so will our recall.’

Read here (The Atlantic, Mar 8, 2021)

US CDC issues ‘Interim public health recommendations for fully vaccinated people’

Fully vaccinated people can:

  • Visit with other fully vaccinated people indoors without wearing masks or physical distancing
  • Visit with unvaccinated people from a single household who are at low risk for severe COVID-19 disease indoors without wearing masks or physical distancing
  • Refrain from quarantine and testing following a known exposure if asymptomatic

For now, fully vaccinated people should continue to:

  • Take precautions in public like wearing a well-fitted mask and physical distancing
  • Wear masks, practice physical distancing, and adhere to other prevention measures when visiting with unvaccinated people who are at increased risk for severe COVID-19 disease or who have an unvaccinated household member who is at increased risk for severe COVID-19 disease
  • Wear masks, maintain physical distance, and practice other prevention measures when visiting with unvaccinated people from multiple households
  • Avoid medium- and large-sized in-person gatherings
  • Get tested if experiencing COVID-19 symptoms
  • Follow guidance issued by individual employers
  • Follow CDC and health department travel requirements and recommendations

Read here (US CDC, Mar 8, 2021) 

Sunday 7 March 2021

What’s ahead in the second year of Covid-19?

‘When COVID-19 began its insidious march across the globe more than a year ago, it disrupted every industry and forced fast innovation as business leaders worked to adjust to a new world order. Last year, in Wharton’s Fast Forward video series, several of the School’s faculty offered their insight into what the second half of 2020 would look like during the pandemic. That insight is needed even more this year as the ground keeps shifting, vaccines are rolled out, and new coronavirus mutations emerge.

‘Much has changed since the start of the pandemic, from consumer behavior to health care delivery to working from home. What changes are lasting? And what lessons have we learned? We’ve asked some of our faculty to analyze what’s in store for the rest of 2021. Their responses appear below:

  • Will working from home become permanent for nonessential employees?
  • What’s the outlook for the stock market and the economy this year?
  • How will the pandemic continue to change the delivery of health care in the U.S.?
  • What crisis management lessons will business leaders keep going forward?
  • What changes in retail and shopping will become permanent?
  • What is the future of the gig economy in the U.S.?

Read here (Wharton@Knowledge, Mar 8, 2021) 

In 2018, diplomats warned of risky Coronavirus experiments in a Wuhan lab. No one listened

‘Knowing the significance of the Wuhan virologists’ discovery, and knowing that the WIV’s top-level biosafety laboratory (BSL-4) was relatively new, the U.S. Embassy health and science officials in Beijing decided to go to Wuhan and check it out. In total, the embassy sent three teams of experts in late 2017 and early 2018 to meet with the WIV scientists, among them Shi Zhengli, often referred to as the “bat woman” because of her extensive experience studying coronaviruses found in bats.

‘When they sat down with the scientists at the WIV, the American diplomats were shocked by what they heard. The Chinese researchers told them they didn’t have enough properly trained technicians to safely operate their BSL-4 lab. The Wuhan scientists were asking for more support to get the lab up to top standards...

‘Taken together, those two points—a particularly dangerous groups of viruses being studied in a lab with real safety problems—were intended as a warning about a potential public-health crisis, one of the cable writers told me. They kept the cables unclassified because they wanted more people back home to be able to read and share them, according to the cable writer. But there was no response from State Department headquarters and they were never made public. And as U.S.-China tensions rose over the course of 2018, American diplomats lost access to labs such as the one at the WIV.’

Read here (Politico, March 8, 2021)

Covid-19's impact could mean millions more child marriages: UNICEF

‘The outsized impact COVID-19 has had on women in some countries could result in an additional 10 million child marriages in this decade, according to a new analysis released on Monday (Mar 8) by UNICEF. "School closures, economic stress, service disruptions, pregnancy and parental deaths due to the pandemic are putting the most vulnerable girls at increased risk of child marriage," said a study titled COVID-19: A Threat to Progress Against Child Marriage.’

Read here (Straits Times, Mar 7, 2021)

China to issue ‘health certificates’ for travel; open to vaccinate athletes for Games: Foreign Minister

‘China said on Sunday (March 7) that it would be issuing "health certificates" - an apparent first step to a global health passport - to allow for international travel amid the Covid-19 pandemic. The country is also open to working with the International Olympic Committee to immunise athletes taking part in the sporting event.

‘It would also be setting up regional vaccination sites to inoculate its citizens overseas, Foreign Minister Wang Yi said at his annual press conference.’

Read here (Straits Times, Mar 7, 2021)

The Nightingale alternative: Cast out fear in favour of love

‘According to Miss Nightingale: “True nursing ignores infection, except to prevent it. Cleanliness and fresh air from open windows, with unremitting attention to the patient, are the only defence a true nurse either asks or needs. Wise and humane management of the patient is the best safeguard against infection.”

‘Tell that to those who decided that old people already suffering from life-threatening complaints should be shut away for months on end, deprived of free movement in the open air and of the contact they crave with those they love!

‘And what would a woman who remarked, “How very little can be done under the spirit of fear!” have thought of the deliberate incitement of terror which has been the hallmark of public policy in the UK for the past eleven months?

‘What would her opinion have been of a government that splashes out apparently unlimited sums of public money on fear-inducing propaganda, with the aim of increasing “the perceived level of personal threat…using hard-hitting emotional messaging”?

‘A Nightingale approach to Covid, and to all infections, would allow us to cast out fear in favour of love, resolving the present conflict between concern for public health and the moral imperatives which should always take precedence over panicked speculation.

‘It would, however, be exceedingly inconvenient for those currently seizing the chance to impose their anti-human agendas on humanity, under cover of a pandemic.’

Read here (OffGuardian, Mar 7, 2021) 

India’s Covid vaccine rollout ‘rescued the world’: Top US scientist

‘Dr Peter Hotez, Dean of the National School of Tropical Medicine at Baylor College of Medicine (BCM) in Houston during a recent webinar said that the two mRNA vaccines may not impact the world's low- and middle-income countries, but India's vaccines, made in collaboration with universities across the world such as BCM and the Oxford University, have "rescued the world" and its contributions must not be underestimated.

‘During the webinar, "Covid-19: Vaccination and Potential Return to Normalcy - If and When", Dr Hotez, an internationally-recognised physician-scientist in neglected tropical diseases and vaccine development, said that the Covid-19 vaccine rollout is "India's gift'' to the world in combating the virus.

‘India's drugs regulator gave emergency use authorisation to Covishield, produced by Pune-based Serum Institute of India after securing licence from British pharma company AstraZeneca, and Covaxin, indigenously developed jointly by Hyderabad-based Bharat Biotech and Indian Council of Medical Research scientists.’

Read here (India Today, Mar 7, 2021)

Saturday 6 March 2021

Oral Covid-19 treatment yields promising trial data: Drugmakers

‘German pharmaceutical giant Merck and a US partner reported promising results on Saturday (Mar 6) in trials of a drug administered orally to fight COVID-19, saying it helps reduce patients' viral load...

‘In January, Merck halted work on two COVID-19 vaccine candidates but has pressed on with research into two products to treat the disease, including a pill-based one called molnupiravir, which it has developed with Ridgeback Biotherapeutics.

‘This drug caused a significant drop in patients' viral load after five days of treatment with it, Merck said at a meeting with infectious disease experts. This Phase 2A test - drug trials have three stages before a product can be approved - was carried out among 202 non-hospitalised people with symptoms of COVID-19.’

Read here (Channel News Asia, Mar 7, 2021)

The antibody deception

‘Virtually every study and piece of marketing material related to Covid is premised on scientists having positively and correctly identified the presence of the novel coronavirus (also known as SARS-CoV-2) in the material they’re working with.

‘The job of that identification is usually given to antibodies that are said to bind to the novel coronavirus. The assumption is these antibodies are able to pick out the virus and only the virus from among every other organism and substance surrounding it.

‘Unfortunately it turns out that the antibodies rarely (if ever) do that. This is because of, among other things, inadequate verification of the antibodies’ accuracy in targeting the virus by the companies that manufacture and sell them. And there’s even less verification by government regulators.’

Read here (OffGuardian, Mar 6, 2021)

Friday 5 March 2021

Multitude of coronavirus variants found in the US — but the threat is unclear

‘For the scientists who have spent the past year poring over hundreds of thousands of coronavirus genomes, the United States has been an enigma. Despite having world-leading genome sequencing infrastructure and experiencing more COVID infections than any other country, the United States has until recently lagged far behind in sequencing coronavirus genomes and spotting worrisome variants.

‘But in recent weeks, US researchers have identified a host of new variants, including in California, New York State, Louisiana and elsewhere. And they are continuing to ramp up SARS-CoV-2 sequencing efforts.

‘That has brought another challenge: making sense of the variants that are discovered. They carry potentially worrying mutations and might be becoming more common, but a dearth of data on how the variants are spreading means the threat they pose is unclear.’

Read here (Nature, Mar 6, 2021)

From Pfizer to Moderna: Who's making billions from Covid-19 vaccines?

‘Among the biggest winners will be Moderna and Pfizer – two very different US pharma firms which are both charging more than $30 per person for the protection of their two-dose vaccines. While Moderna was founded just 11 years ago, has never made a profit and employed just 830 staff pre-pandemic, Pfizer traces its roots back to 1849, made a net profit of $9.6bn last year and employs nearly 80,000 staff.

‘But other drugmakers, such as the British-Swedish AstraZeneca and the US pharma Johnson & Johnson, have pledged to provide their vaccines on a not-for-profit basis until the pandemic comes to an end.’

Also carried in this story are: Sinovac, Sputnik V, Novavax, CureVac 

Read here (The Guardian, Mar 6, 2021)

The political economy of Covid-19 vaccines

‘Vaccine grabs, the refusal to relax patents to enable mass production, and the use of vaccines for diplomacy run the risk that poorer nations may not be protected against Covid-19 quickly enough. This will prolong the pandemic, even for the richer nations.’

Read here (The India Forum, Mar 5, 2021)

I’m alive today because of our healthcare frontliners! — Joseph Ong See Sung

‘While at the hospital, I also made many friends among the patients. I was touched by what I saw. Everyone in the ward was helping one another. There was no racial barrier. Everyone took turns to look out for one another. I told myself — this should be the Malaysia that we should have, not one that’s divisive and ruined by people with selfish interests! 

‘I saw one very filial son who was with his father. Both had Covid-19. But this young man, despite being down with the virus, made all efforts to care for his father, who even suffered a stroke there! 

‘Every minute of my waking hour there, I saw people putting aside their personal and ethnic differences to help anyone within their sight! It warmed my heart and spurred me to get better so that I can tell the outside world that people were so caring at the hospitals. Both frontliners and patients! Why can’t more people be like that?’

Read here (Malay Mail, Mar 5, 2021)

Thursday 4 March 2021

The secret weapon [abolishing factory farming] against pandemics that nobody wants to talk about | Alex O'Connor

‘Alex O’Connor is a prominent podcaster, YouTuber and student at the University of Oxford. In his TEDx talk, Alex puts forward the case against factory farming, not only based on ethical concerns, but also by exploring how factory farms can become breeding grounds for Zoonotic viruses.’

View here (TedTalk, Youtube, Mar 5, 2021)

Germany approves AstraZeneca vaccine for over-65s

‘Germany's vaccine commission has approved the use of the Oxford-AstraZeneca jab in people aged over 65. The country previously approved it for under-65s only, citing insufficient data on its effects on older people. That led to public scepticism about its effectiveness, with some Germans spurning it and leaving many doses unused.

‘But German Chancellor Angela Merkel said recent studies had now provided enough data to approve it for all ages. Announcing the commission's decision on Thursday, Health Minister Jens Spahn said the move was "good news for older people who are waiting for an injection".’

Read here (BBC, Mar 5, 2021) 

Finding an ultimate vaccine to fight the mutating “emperor” virus

‘We are commenting on the shocking CNN website report (March 2), headlined “All our recent progress with COVID-19 could be wiped out by variants, CDC director says”. The first two paragraphs (below) are enough to sum up the CNN report: “The US is at risk of losing all its recent gains in the battle against COVID-19 as highly contagious variants take advantage of Americans getting lax with safety measures... “Please hear me clearly: At this level of cases with variants spreading, we stand to completely lose the hard-earned ground we have gained,” said Dr Rochelle Walensky, director of the US centers for Disease Control and Prevention (CDC).”...

‘With new variants, serious doubts are suggested by the CNN report on whether this “vaccine” [mRNA], the first in the global market, would work, even if safety factor is put aside. Nevertheless, there are safe and workable vaccines, using tried and tested technologies like using inactivated or attenuated virus from nature to stimulate the body to produce anti-body response. Even the adenovirus viral vector technology, tried and tested for Ebola, appears to be safer than mRNA.

‘There are also safe and good alternatives, like the anti-viral “broad spectrum” drug Ivermectin, which can destroy the new variants. In the meantime, it is vital that we improve our body immunity against COVID-19 by taking Vitamin C with zinc, Vitamin D, minerals and trace elements needed, explore proven traditional and complimentary medicines, and maintain established standard operating procedures (SOPs) of physical distancing, wearing surgical masks and personal hygiene in public places.’

Read here (Focus Malaysia, Mar 4, 2021)

China’s vaccine diplomacy falls flat in the Philippines

‘The Philippines has finally kicked off its Covid-19 vaccine rollout with much-publicized donations from China but rising controversies around the rollout will prevent Beijing from declaring a “vaccine diplomacy” win.

‘China recently delivered 600,000 doses of the vaccine developed by the Beijing-based company Sinovac Biotech and frontliners across the country are set to be among the primary beneficiaries. The drive kicks off as the Philippines grapples with one of the region’s worst outbreaks and steepest economic recessions caused by extended lockdowns.’

Read here (Asia Times, Mar 4, 2021)

Fighting the medical monopoly: Mobilising for Zero-Covid and decommodified healthcare

‘As I have discussed in an article on Interferon 2b and Cuba’s other treatments for COVID-19, decommodified universal healthcare is the alternative to monopoly-driven healthcare ravaging countries around the globe. Not for profit production and delivery of all health related goods responding to general and specific human needs of the majority of any given country is the only means to assure quality health for all, in pandemic as well as non-pandemic times.

‘More concretely, decommodified universal healthcare is ecologically sound, public sector production of everything from food to psychological support, medicines to medical technology, and medical care. Rather than results based management and other corporate models adopted by most state owned enterprises globally in the past four decades, such public production would be designed and managed democratically by citizens, health professionals, scientists, and the range of other workers involved.

‘Taxation of corporations and rich individuals would be the primary means of financing decommodified universal healthcare. Due to the social importance of health related goods, and high employment potential given the extent of need in most countries around the globe, decommodified universal healthcare would constitute a significant segment of needs based, ecologically sound, nationally focused economies.’

Read here (The Bullet, Mar 4, 2021)

Without official vaccine guidance, pregnant people are left to do their own research

‘The lack of clear guidance around pregnancy has ripple effects. Despite abundant evidence that the vaccines are safe for lactating parents and their babies, last month the Chicago Tribune reported that a new mom who was breastfeeding was denied the COVID-19 vaccine by her county’s health department. Officials said they decided not to allow pregnant or lactating women to receive the vaccine, citing a lack of data.

‘Dr. Peter Hotez, a vaccinologist and dean of the National School of Tropical Medicine at Baylor College of Medicine, told me he was appalled by the mixed messaging around vaccines in pregnancy, which he said leaves patients “reading the tea leaves.” The government “has not made a good faith effort to take down the anti-vaccine misinformation and disinformation,” he said. “So by telling a pregnant woman to do her own research online means you’re basically telling her not to get vaccinated.”

Read here (Mother Jones, Mar 4, 2021)

Wednesday 3 March 2021

Effect of ivermectin on time to resolution of symptoms among adults with mild Covid-19: A randomised clinical trial

‘In this randomized clinical trial that included 476 patients, the duration of symptoms was not significantly different for patients who received a 5-day course of ivermectin compared with placebo (median time to resolution of symptoms, 10 vs 12 days; hazard ratio for resolution of symptoms, 1.07).

‘The findings do not support the use of ivermectin for treatment of mild COVID-19, although larger trials may be needed to understand effects on other clinically relevant outcomes.’

Read here (JamaNetwork, Mar 4, 2021)

India's Covid vaccine wins over some sceptics after promising data

‘Indian doctors and politicians on Thursday welcomed efficacy data for a state-backed coronavirus vaccine that was given emergency approval in January without the completion of a late-stage trial, making people reluctant to receive the shot.

‘Government data shows (dashboard.cowin.gov.in) that only 10% of about 13.3 million people immunised in India have taken the COVAXIN shot, which was found to be 81% effective in an interim analysis of the late-stage trial, its developer Bharat Biotech said on Wednesday.’

Read here (Reuters, Mar 4, 2021)

Covid year: Topsy-turvy and gains

‘What should spring up eternally is compassion, tolerance, humility and other qualities that would unite us in this beloved land no matter what our ethnic or religious affiliations...

‘Any change in societal or personal lives is influenced by gender, social class, race, culture, age and other variables. I can only speak as a 73-year-old woman, former academic, Christian and Malaysian-Chinese, and post-polio person. Each facet of our multi-layered identity will be affected in different degrees by this season of Covid-19.’

Read here (Aliran, Mar 4, 2021)

How Covid-19 vaccine efforts could help defeat other diseases

  • A proposed way of immunizing against malaria uses an RNA-based approach similar to COVID-19 vaccines.
  • ‘Viral vector’ methods used to stem the pandemic could also yield vaccines for other purposes.
  • COVID-19 vaccination achievements could be applied to diseases that kill millions of people annually.

Read here (World Economic Forum, Mar 4, 2021)

Why has P1 appeared? Heads it wins, tails we lose?

‘You may already know that viruses mutate, that this is normal and these small changes to the virus’s genetic code are to be expected. Well, that’s true, but that doesn’t mean they’re always harmless. Many mutations will be irrelevant, and some will make a virus weaker and will die out. But others will make it fitter, giving it an advantage over other variants and allowing it to out-compete them.

‘As people socially distance, observe stricter personal hygiene and wear masks, it becomes an advantage for the virus to be more transmissible. Similarly, as more people around the world gain immunity through being infected or vaccinated, another advantage would be for the virus to change so that antibodies can no longer attach to it and prevent it from infecting cells.

‘It’s therefore not surprising to see variants with mutations that provide these advantages now out-competing other forms of the coronavirus. Control measures and rising immunity are pressuring the coronavirus to evolve.’

Read here (The Conversation, Mar 3, 2021)

As the world vies for vaccines, Cuba’s making its own

‘Cuba may be on the verge of a coronavirus vaccine breakthrough and not a moment too soon, as deaths and cases spike on the communist-run island.

‘Starting in March, two of the island's four homegrown vaccine candidates will begin their third and final trials, the Cuban government has announced. While other developing countries compete with richer nations for a limited supply of doses, Cuba has gambled everything on producing their own vaccines, as much an exercise in national pride as a response to a public health crisis.’

Read here (CNN, Mar 3, 2021)

US Catholic group tells followers to avoid Johnson & Johnson vaccine

‘An American Catholic church body on Tuesday urged its followers to avoid the coronavirus vaccine developed by Johnson & Johnson, alleging that it was “developed, tested and produced using abortion-derived cell lines.”

‘The US Conference of Catholic Bishops (USCCB) urged Catholics to choose between the alternatives offered by Pfizer and Moderna because the J&J vaccine raised questions about “moral permissibility.”

“The approval of Johnson & Johnson’s Covid-19 vaccine for use in the United States again raises questions about the moral permissibility of using vaccines developed, tested, and/or produced with the help of abortion-derived cell lines,” said Bishop Kevin C Rhoades, chairman of USCCB.’

Read here (Independent, Mar 3, 2021) 

Tuesday 2 March 2021

‘A conflict of interest mars paper on Ayurvedic Covid drug Coronil – and it should be retracted’

‘Yoga guru Baba Ramdev and his FMCG company Patanjali Ayurved have recently been in the news for advancing a supposedly Ayurvedic drug named Coronil as the “first evidence-based medicine” for COVID-19. But despite the dubiety of this claim, Coronil has been approved for sale by the Government of India on the sole basis of a scientific paper, published in the journal Phytomedicine in February 2021.

‘A previous article discussed the wobbly assertions in the paper and their mismatch with Patanjali’s conclusion that Coronil has been properly tested or that it is efficacious. But there is another bit of detail that may disqualify the paper’s publication itself. In the paper’s ‘Declaration of Competing Interest’ section, the authors say:

“Authors declare no conflict of interests with regards to the submitted work. The medications were provided by Divya Pharmacy, Haridwar, Uttarakhand, India. Acharya Balkrishna is an honorary trustee in Divya Yog Mandir Trust. Besides, providing the medications, Divya Pharmacy was not involved in any aspect of the clinical trial reported in this study. Clinical trial was conducted at National Institute of Medical Sciences, Jaipur, India.”

Read here (Science TheWire, Mar 3, 2021)

Science and society are failing children in the Covid Era

‘In spite of the increasingly polarized debate about school reopenings, community infection rates and prioritization of vaccination, it seems clear that both science and society are failing children. Children have proven uniquely resilient to COVID-19, but many are already suffering lasting educational, mental and physical harms. The greatest harm is falling on the most vulnerable children, and yet we know so little of the true extent and duration of these harms, because relatively little research has focused on them, compared to the research on COVID-19-related spread and mitigation.

‘School closures are a prominent example where following the science is not in itself an answer. These are hard decisions based on ethical and moral considerations for elected officials to make, in ways that acknowledge the evidence on the harms, the requirement for safeguarding and the emerging evidence on COVID-19. Understanding the evidence on the potential trade-offs for children is a critical component of such policies and decisions. It is time science and society elevated this central responsibility.’

Read here (Scientific American, Mar 3, 2021) 

Don’t let private hospitals jump the vaccination queue ― no special privileges for the rich! ― Suaram

‘Suara Rakyat Malaysia (Suaram) believes that the commercialisation of the Covid-19 vaccination by the private hospitals would only encourage “queue-cutting” where the rich and powerful stands to gain and potentially undermine the government's national programme and weakens social solidarity.

‘Furthermore, allowing private hospitals to procure vaccines and subsequently running their own vaccination programme also contradicts the principles of giving everyone an equal opportunity in the country’s largest vaccination programme ever.’

Read here (Malay Mail, March 3, 2021)

Malaysia approves Sinovac, AstraZeneca Covid-19 vaccines for use

‘Malaysia on Tuesday (Mar 2) granted conditional approval for the use of vaccines made by UK firm AstraZeneca and China's Sinovac, just days after launching its nationwide COVID-19 inoculation programme. Malaysia began its vaccination drive on Feb 24 using a shot developed by US drugmaker Pfizer and German partner BioNTech, as it tries to rein in a spike in infections and help revive an economy that recorded its worst slump in more than two decades last year.’

Read here (Channel News Asia, Mar 2, 2021)

The Covid bubble

‘When it comes to this year, growth may yet fall short of expectations. New strains of the coronavirus continue to emerge, raising concerns that existing vaccines may no longer be sufficient to end the pandemic. Repeated stop-go cycles undermine confidence, and political pressure to reopen the economy before the virus is contained will continue to build. Many small- and medium-size enterprises are still at risk of going bust, and far too many people are facing the prospects of long-term unemployment. The list of pathologies afflicting the economy is long and includes rising inequality, deleveraging by debt-burdened firms and workers, and political and geopolitical risks.

‘Asset markets remain frothy – if not outright bubbly – because they are being fed by super-accommodative monetary policies. But today’s price/earnings ratios are as high they were in the bubbles preceding the busts of 1929 and 2000. Between ever-rising leverage and the potential for bubbles in special-purpose acquisition companies, tech stocks, and cryptocurrencies, today’s market mania offers plenty of cause for concern.’

Read here (Project Syndicate, Mar 2, 2021)

China ships millions of Covid-19 vaccines to poor nations abroad; denies ‘vaccine diplomacy’

‘China's vaccine diplomacy campaign has been a surprising success: It has pledged roughly half a billion doses of its vaccines to more than 45 countries, according to a country-by-country tally by The Associated Press. With just four of China's many vaccine makers claiming they are able to produce at least 2.6 billion doses this year, a large part of the world's population will end up inoculated not with the fancy Western vaccines boasting headline-grabbing efficacy rates, but with China's humble, traditionally made shots.

‘Amid a dearth of public data on China's vaccines, hesitations over their efficacy and safety are still pervasive in the countries depending on them, along with concerns about what China might want in return for deliveries. Nonetheless, inoculations with Chinese vaccines already have begun in more than 25 countries, and the Chinese shots have been delivered to another 11, according to the AP tally, based on independent reporting in those countries along with government and company announcements.’

Read here (CP24, Mar 2, 2021)

The search for animals harbouring coronavirus — and why it matters

‘Ever since the coronavirus started spreading around the world, scientists have worried that it could leap from people into wild animals. If so, it might lurk in various species, possibly mutate and then resurge in humans even after the pandemic has subsided.

‘That would bring the tale of SARS-CoV-2 full circle, because wild animals probably brought it to humans in the first place. Strong evidence suggests that the virus originated in horseshoe bats (Rhinolophus spp.), possibly hitching a ride on other animals before infecting people1. In the current stage of the pandemic, with hundreds of thousands of confirmed COVID-19 infections every day, people are still driving transmission of SARS-CoV-2. But years from now, when community spread has been suppressed, a reservoir of SARS-CoV-2 in free-roaming animals could become a recalcitrant source of new flare-ups.’

Read here (Nature, Mar 2, 2021)

Coronavirus crisis unlikely to be over by the end of the year, WHO warns

‘Despite the spread of Covid-19 being slowed in some countries due to lockdowns and vaccination programs, it is “premature” and “unrealistic” to the think the pandemic will be over by the end of the year, the World Health Organization’s executive director of emergency services has said.

‘Speaking at a press briefing Geneva, Dr Michael Ryan said while vaccinating the most vulnerable people, including healthcare workers, would help remove the “tragedy and fear” from the situation, and would help to ease pressure on hospitals, the “virus is very much in control”.’

Read here (The Guardian, Mar 2, 2021) 

NIH halts trial of Covid-19 convalescent plasma in emergency department patients with mild symptoms: ‘Safe but no significant benefit’

‘The National Institutes of Health has halted a clinical trial evaluating the safety and effectiveness of COVID-19 convalescent plasma in treating emergency department patients who developed mild to moderate symptoms of COVID-19, the disease caused by the coronavirus SARS-CoV-2.

‘An independent data and safety monitoring board (DSMB) met on Feb. 25, 2021 for the second planned interim analysis of the trial data and determined that while the convalescent plasma intervention caused no harm, it was unlikely to benefit this group of patients. After the meeting, the DSMB recommended that the National Heart, Lung, and Blood Institute (NHLBI), part of NIH, stop enrolling new patients into the study. NHLBI did so immediately.’

Read here (NIH, Mar 2, 2021) 

Monday 1 March 2021

Coronil: The misleading claims about an Indian remedy

‘A controversial herbal concoction has been in the news again in India, with renewed claims that it is effective against coronavirus. The substance, called Coronil, was launched recently at an event attended by some Indian government ministers. But there is no evidence that it works, and misleading claims have been made about approval for its use.’

Read here (BBC, Mar 2, 2021) 

Countries urge drug companies to share vaccine know-how

‘Across Africa and Southeast Asia, governments and aid groups, as well as the World Health Organization, are calling on pharmaceutical companies to share their patent information more broadly to meet a yawning global shortfall in a pandemic that already has claimed over 2.5 million lives. Pharmaceutical companies that took taxpayer money from the U.S. or Europe to develop inoculations at unprecedented speed say they are negotiating contracts and exclusive licensing deals with producers on a case-by-case basis because they need to protect their intellectual property and ensure safety.’

Read here (AP, Mar 2, 2021)

100,000 deaths and a White Paper: What we need instead in Britain

‘We must refuse to engage on this paltry terrain. The pandemic, and the government’s abject failure to respond to it, should prompt a radical set of popular demands. Not since 1948 has there been such overwhelming public support for the NHS, or for the medical scientists and public health experts without whose knowledge and warnings even more lives would have been lost. In this context, and in recognition of how close we have come to an even greater disaster, we must reject this tinkering with the status quo.

‘Integration’ has served as a useful cover for Simon Stevens’s dismantling of the Lansley competition-based model, but it is a perverse misnomer for what the white paper proposes to embody in law. True integration is incompatible with a system of in-built conflicts of interest. Decisions about service provision need to be clearly accountable both to Parliament, and locally, to the public, neither of which is the case in what is proposed. Integration of healthcare with social care is indeed also needed, but is only possible if social care also becomes a public service. And neither this, nor adequate funding for the NHS, is ‘unaffordable’, especially while real interest rates are negative. What is unaffordable is to face the next pandemic as unprotected as we were for COVID-19.’

Read here (The Bullet, Mar 2, 2021)

Don’t rush vaccine passports, address fundamental issues ― Ameen Kamal

‘As it would take time for nations to reach herd immunity, mechanisms to help re-open the economy and international borders such as health passports have been met with increased enthusiasm and strong support from economic sectors.

‘However, issues related to immunological uncertainties, social-ethical concerns related to its implementation as well as operational challenges in global standardisations have to be addressed in order for vaccine passports to be effective.’

Read here (Malay Mail, March 2, 2021)

Children’s hospitals grapple with young Covid ‘long haulers’

‘While statistics indicate that children have largely been spared from the worst effects of covid, little is known about what causes a small percentage of them to develop serious illness. Doctors are now reporting the emergence of downstream complications that mimic what’s seen in adult “long haulers.”

‘In response, pediatric hospitals are creating clinics to provide a one-stop shop for care and to catch any anomalies that could otherwise go unnoticed. However, the treatment offered by these centers could come at a steep price tag to patients, health finance experts warned, especially given that so much about the condition is unknown.

‘Nonetheless, the increasing number of patients like Delaney is leading to a more structured follow-up plan for kids recovering from covid, said Dr. Uzma Hasan, division chief of pediatric infectious diseases at St. Barnabas Medical Center in New Jersey.’

Read here (KHN News, Mar 2, 2021)

Neoliberal finance undermines poor countries’ recovery

‘After being undermined by decades of financial liberalisation, developing countries now are not only victims of vaccine imperialism, but also cannot count on much financial support as their COVID-19 recessions drag on due to global vaccine apartheid...

‘Undoubtedly, distressed developing countries desperately need foreign exchange to cope. But IMF Managing Director Kristalina Georgieva’s call to boost global liquidity with “a sizeable SDR” (Special Drawing Right) allocation was blocked by the Trump administration, who objected that it would give China, Iran, Russia, Syria and Venezuela access to new funds.

‘The Financial Times (FT) argues that the proposed new SDR1tn (US$1.37tn) issuance – almost five times the US$283bn issued in 2009 – is justified by the scale of the crisis. For the FT, it would be “the simplest and most effective way to get additional purchasing power into the hands of the countries that need it”...

‘With 85% of IMF votes required to issue new SDRs, and the US holding veto power with 16.5%, Biden administration support is vital. For SDR issuance under US$650 billion, the White House only needs to consult, rather than get approval from the US Congress.’

Read here (IPS News, Mar 1, 2021)

The raging evolutionary war between humans and Covid-19

‘Fighting the pandemic isn’t only about vaccines and drugs. It’s about understanding how viruses mutate and change inside us, and among us...

‘The major change to the immunity of all the hosts SARS-CoV-2 is likely to try to infect will be, of course, vaccination. That’s human ingenuity fighting viral expertise, but it can also exert a kind of direct adaptive pressure on the virus. History has examples of so-called leaky vaccines—those that aren’t effective enough to prevent all infections or all transmission, and allow better-adapted variants of whatever bug they’re trying to squish to live to fight another day.

‘In fact, one group of researchers has a model that suggests that could even happen with the new batch of vaccines against Covid—especially those that require two doses and seem to confer different levels of immunity depending on how far apart they’re administered, or whether someone skips the second one. Here's how: If one extreme is a population totally naive to a new virus, completely vulnerable and with no immunity, and the other extreme is a population with perfect sterilizing immunity, what happens to a population in between? If a vaccine allows infection but no transmission, the virus doesn’t have a chance to evolve.

‘But if a vaccine or vaccination strategy allows some infection and some transmission? “The ones that are the best at getting around the host’s defenses are the ones that are most likely to persist,” says Caroline Wagner, a bioengineer at McGill and one of the people working on the model. If that’s all true, a leaky vaccine or leaky vaccination strategy could actually drive antigenic drift and create even worse variants. Wagner and her colleagues acknowledge that they don’t have enough data to put bounds on their model yet, but they worry about strategies like one proposed in the UK to abandon second doses as a way of speeding the process and husbanding scarce vaccine, or the way some countries are hoarding vaccine while others go without (potentially letting the virus, and variants, circulate and evolve freely).’

Read here (Wired, Mar 1, 2021)

I have allergies – Can I take the Covid-19 vaccine? — Dr Amar-Singh HSS

‘I believe there are three possible options for those of us with severe allergies:

  • We may choose not to get vaccinated as we feel the risk is too high. But we will have to accept a much stricter SOP for our lives and be prepared to have our lives restricted for some time.
  • The second option is that we choose to vaccinate and, due to the high risk, ask that it be done with enhanced health professional support, i.e. vaccinate in a hospital and have good backup with adrenaline at hand.
  • The third option is to delay vaccination and watch the data as more is made available. The risk of anaphylaxis is small and likely to be even smaller as we get more vaccination data. We will also have a clearer idea which vaccine has the lowest rate of severe allergic reaction. Once this data is available we hope to be able to choose the least allergic vaccine and vaccinate in a hospital with good physician backup.’

Read here (Code Blue, Mar 1, 2021)

Worst ever Covid variant? Omicron

John Campbell shares his findings on Omicron.  View here (Youtube, Nov 27, 2021)