Pandemic, ‘Great Reset’ and resistance

‘The Covid pandemic is a turning point, an opportunity to change. The reset we need now is not the creation of a ‘post-human, post-nature’ world defined by unregulated corporate-led growth of artificial intelligence and biotechnology. We need to balance digitalization and commoditization with an ecological reset, a way of living that respects the environment, promotes agroecology, bioregionalism and local communities. We need to raise our consciousness and understanding of humanity as a species in nature, our connectedness to each other and the rest of planetary life.’

Read here (IPS News, Dec 1, 2020)

Five things you need to know about living with a disability during Covid-19

1. Risk of contracting COVID-19 is higher for persons with disabilities
2. Risk of severe symptoms and death is higher
3. Living in institutions increases the risk of contracting and dying from COVID-19
4. Discrimination in accessibility of healthcare and life-saving procedures
5. The broader COVID-19 crisis affects persons with disabilities more

Read here (UN DESA Voice, December 2020)

Zoom and gloom: How empathy and creativity can re-humanise video conferencing

‘Sitting in a videoconference is a uniformly crap experience. Instead of corroding our humanity, let’s design tools to enhance it...

‘Looking back on my experience of videoconferencing, I still get an odd emotional pain. The feeling is a kind of shame. Not so much for my own wooden performance and the failure of the technology. But rather a feeling that we have all lost a bit of our humanity through it. My interest in these technologies is ethically motivated. I am not at all happy with the banal dehumanisation that results from bad videoconferencing experiences. If, for example, students and teachers can’t express their humanity in education, through its technologies, then we’re just not doing it right.

‘However, I’d like to think that this exploration of videoconferencing in contrast with other more humane experiences has provided some hope and indications of the way to go... That’s how designing works: incremental improvements based on insights drawn from experience. Let’s be optimistic, and keep designing to humanise tech, and using tech to learn about being better humans.’

Read here (Aeon, Dec 1, 2020)

US Covid cases found as early as December 2019, says study

‘Testing has found Covid-19 infections in the U.S. in December 2019, according to a study, providing further evidence indicating the coronavirus was spreading globally weeks before the first cases were reported in China.

‘The study published Monday identified 106 infections from 7,389 blood samples collected from donors in nine U.S. states between Dec. 13 and Jan. 17. The samples, collected by the American Red Cross, were sent to the U.S. Centers for Disease Control and Prevention for testing to detect if there were antibodies against the virus...

‘The revelations in the paper by researchers from the CDC reinforce the growing understanding that the coronavirus was silently circulating worldwide earlier than known, and could re-ignite debate over the origins of the pandemic.’

Read here (Bloomberg, Dec 1, 2020)

The surprising mental toll of Covid

‘You didn't need a crystal ball to forecast that the COVID-19 pandemic would devastate mental health. Illness or fear of illness, social isolation, economic insecurity, disruption of routine and loss of loved ones are known risk factors for depression and anxiety. Now studies have confirmed the predictions. But psychologists say the findings also include surprises about the wide extent of mental distress; the way media consumption exacerbates it; and how badly it has affected young people.

‘For example, a report from the U.S. Centers for Disease Control and Prevention, published in August, found a tripling of anxiety symptoms and a quadrupling of depression among 5,470 adults surveyed compared with a 2019 sample. Similarly, two nationally representative surveys conducted in April, one by researchers at the Boston University School of Public Health and another at Johns Hopkins University, found that the prevalence of depressive symptoms (B.U.) and “serious psychological distress” (Hopkins) were triple the level measured in 2018. “These rates were higher than what we've seen after other large-scale traumas like September 11th, Hurricane Katrina and the Hong Kong unrest,” says Catherine Ettman, lead author of the B.U. study.’

Read here (Scientific American, Dec 1, 2020)

An effective response to Europe’s fiscal paralysis: George Soros

‘With Hungary and Poland vetoing the EU budget and Covid recovery fund, the case for issuing perpetual bonds has never been stronger

‘Perpetual bonds offer the great advantage that the principal never has to be repaid; only the annual interest is due. The discounted present value of future interest payments diminishes over time – it will approach, but never reach, zero. A certain amount of financial resources – say, the €1.8tn currently planned – would go several times further if it were used to issue perpetual bonds rather than ordinary bonds. This would largely solve Europe’s financial problems.

‘If one country issued perpetual bonds, it would have the additional advantage that other European countries would find it an example worth following. The Frugal Five should find perpetual bonds particularly attractive. After all, they like to save money.’

Read here (The Guardian, Dec 1, 2020)

UN special session on Covid-19 must recognise right to health & access to vaccines

‘The UN General Assembly is holding a Special Session on the Covid-19 pandemic at the level of Heads of State and Government on 3 and 4 December.. It took more than a year of discussions to overcome the opposition of certain states, notably the United States and President Donald Trump.

‘The holding of this Special Session (the 37th in the history of the UN) is of considerable importance. It is a unique opportunity to define and implement joint actions at the global level to fight the pandemic in order to ensure the right to life and health for all the inhabitants of the Earth. As the President of the UN General Assembly wrote in his letter of convocation: “Let us not forget that none of us are safe until we are all safe”....’

This is a lengthy opinion piece by Riccardo Petrella, Emeritus Professor, Catholic University of Louvain (Belgium). His research and teaching fields have been regional development, poverty, science and technology policy and globalisation.

Read here (IPS News, Nov 30, 2020)

What you need to know about the Pfizer, Moderna and AstraZeneca vaccines

‘All three drugmakers have moved at record speed, and the first shots of the Pfizer and Moderna vaccines could be given in the coming weeks. This article answers a list of questions that ordinary people need to know before they commit to the vaccinations.’

Read here (Washington Post, Nov 30, 2020)

Babies born to mums with Covid-19 may have antibodies, but scope of protection is unclear

‘Although babies of women infected with Covid-19 during their pregnancies have been born with antibodies, it remains unclear if this means the baby is immune to the coronavirus or how long the immunity would last. Earlier this month, Mrs Celine Ng-Chan, 31, gave birth to her second child and was told by her son's paediatrician that he has antibodies against the virus.’

Read here (Straits Times, Nov 29, 2020)

Public needs to prep for vaccine side effects

‘This summer, computational biologist Luke Hutchison volunteered for a trial of Moderna's COVID-19 vaccine. But after the second injection, his arm swelled up to the size of a “goose egg,” Hutchison says. He can't be sure he got the vaccine and not a placebo, but within a few hours, Hutchison, who was healthy and 43, was beset by bone and muscle aches and a 38.9°C fever. “I started shaking. I had cold and hot rushes,” he says. “I was sitting by the phone all night long thinking: ‘Should I call 911?’”

‘Hutchison's symptoms resolved after 12 hours. But, he says, “Nobody prepared me for the severity of this.” He says the public should be better prepared than he was, because a subset of people may face intense, if transient, side effects, called reactogenicity, from Moderna's vaccine. Some health experts agree.’

Read here (Science, Nov 27, 2020) 

United States: Beyond the wasteland -- New strategies for pivoting from the pandemic crisis to a recovery built on economic justice

‘Decades of falling wage shares mean that millions of households are ready to spend more if only they could earn more income. A well-calibrated recovery strategy that combines public spending on goods and services with regulation of predatory corporate behavior and effective redistribution can unleash a virtuous growth circle that improves living standards for the vast majority and strengthens government finances even as it generates resources to boost public services and tackle the environmental catastrophe.

‘Such a strategy would consist of the following elements:

• A prolonged fiscal expansion with immediate support to employment creation and social services, including a strong component in the care economy;
• Public-infrastructure investment to accelerate the energy transition by combining policies to encourage investments in renewables and discourage fossil fuel extraction;
• Policies to improve industrial capacity based on raising productivity and greater energy efficiency;
• Progressive tax reforms shifting the burden from indirect taxes such as sales and value-added taxes (which are regressive and discourage spending) to direct taxation, especially on high-income earners (whose consumption is relatively unaffected by taxation) and on corporate earnings and rents (with exemptions depending on employment creation).

Read here (The American Prospect, Nov 27, 2020)

AstraZeneca says its Covid-19 vaccine needs 'additional study'

‘The head of British drug manufacturer AstraZeneca said on Thursday (Nov 26) further research was needed on its COVID-19 vaccine after questions emerged over the protection it offers, but the additional testing is unlikely to affect regulatory approval in Europe.

‘Instead of adding the trial to an ongoing US process, AstraZeneca might launch a fresh study to evaluate a lower dosage of its vaccine that performed better than a full dosage, AstraZeneca chief executive Pascal Soriot was quoted as saying in a Bloomberg News report.’

Read here (Channel News Asia, Nov 27, 2020)

WHO to look at controversial Italian samples in search for origins

‘The World Health Organization is looking into controversial research suggesting the coronavirus that causes Covid-19 was circulating in Italy months before it was first detected in China, the health body said on Friday, while cautioning against using such data to speculate about the disease’s origins.

‘The WHO plans to run tests with the Italian researchers who made waves earlier this month for their peer-reviewed findings based on tests of blood samples from a cancer screening carried out starting before the pathogen was detected in China.’

Read here (South China Morning Post, Nov 27, 2020) 

Coronavirus was on many continents before Wuhan outbreak, Chinese team says

‘Paper by Chinese researchers says a strain can be traced to eight countries from four continents before the Wuhan outbreak. First human transmission may have occurred on the Indian subcontinent, it says – but other scientists question the finding.’

Read here (South China Morning Post, Nov 27, 2020)

Gender equality achievements being wiped out by pandemic

‘The coronavirus pandemic could wipe out 25 years of increasing gender equality, new global data from UN Women suggests. Women are doing significantly more domestic chores and family care, because of the impact of the pandemic. "Everything we worked for, that has taken 25 years, could be lost in a year," says UN Women Deputy Executive Director Anita Bhatia. Employment and education opportunities could be lost, and women may suffer from poorer mental and physical health.

Read here (BBC, Nov 27, 2020)

Businesses and residents near Top Glove dormitories on edge, as Covid-19 cases spike among workers

"We didn't know about workers being infected until last week," said resident Kandasamy Padakat Hurian, 43 who lives in a house directly across a worker dormitory. "When I went out to work at 7am on Monday (Nov 16), army trucks and the police were already here. By evening when I returned, the (barbed) wire was in place," Mr Kandasamy recounted. Prior to last week, Jalan Teratai would be busy in the evenings as petty traders and hawkers lined the road with stalls. "When the government came and locked down the place, everyone fled. It has become very quiet,” he said 

Read here (Channel News Asia, Nov 26, 2020)

Some serious questions about the Top Glove cluster – P. Gunasegaram

‘Did world’s No. 1 glove maker put profit over safety?

‘After the Sabah debacle, where unrestricted campaigning ahead of the September 26 state elections and easy travel conditions resulted first in a steep rise in Covid-19 cases in Sabah and subsequently, in the peninsula, the Top Glove cluster now raises serious questions over the lack of controls by a major company and the government itself.

‘It is a wonder that more measures were not taken by both the company and the authorities to control the menace that has become the Top Glove cluster, even though signals were clearly there that things could get out of hand.’

Read here (The Vibes, Nov 26, 2020)

How Covid-19 will impact our cities in the long term

‘The biggest opportunity for cities from this pandemic is to build back better with the planned fiscal stimulus: more climate resilient infrastructure, green initiatives such as increasing public spaces, creating vehicle free streets, making bike lanes, refurbishing buildings to multiple uses and thereby doing more with less. This cannot be done by the public sector alone. Cities will need to attract private sector and social partners to close the financing gap. Good governance is an imperative to attract private financing and to work with the private sector.’

Read here (World Economic Forum, Nov 25, 2020)

With vaccines on the horizon, here’s how business leaders can plan ahead

‘Vaccine announcements get the globe closer to eradicating the virus, but questions still remain. Business leaders will need to consider a range of potential scenarios for access and distribution to adjust to the changes still ahead. For business planning only, Salesforce Future Lab developed a selection of hypothetical scenarios in discussions with leading experts to help leaders understand the range of scenarios for which they might need to plan.’

Hypothetical Scenario 1: “Zero Hurdles” -- In this scenario, business leaders could look forward to the crisis ending as quickly and evenly as possible around the world. In-person work and consumer confidence could come back close to pre-crisis levels over the summer and fall of 2021, though masking, distancing, and ventilation would still be necessary for many more months.

Hypothetical Scenario 2: “Sprint and Stumble” -- In this scenario, many business leaders might initially make investments betting on a rapid re-emergence from crisis conditions, only to be surprised as optimism evaporates. As the crisis stretched on, those who recognized the continuing risk would likely be in the best position, but even they would still face stiff economic headwinds.

Hypothetical Scenario 3: “Long March” -- In this scenario, business leaders could be increasingly challenged to maintain the safety of their staff and customers before the vaccine arrives, as the public becomes less willing to adhere to public health guidance. But after its arrival, the impact is similar to “Zero Hurdles” above, with a relatively rapid return to workplace safety and consumer confidence.

Read here (World Economic Forum, Nov 25, 2020) 

What message will persuade people to take a vaccine?

‘Scientists are charging ahead to make a COVID-19 vaccine available, working out the challenging logistics of wide-scale production and distribution. Milkman is hopeful that the work of the BCFG team will, in turn, help more people take the vaccine. “Even if we get the supply chain issues right, even if we get every corner drugstore to someday be supplying these, we have to get them into arms in order for them to change the course of the pandemic,” she said. “And the messaging is going to be key to that.”

Read here (Knowledge@Wharton, Nov 24, 2020)

Crisis standards of care: Lessons from New York City hospitals’ Covid-19 experience

‘The purpose of this project was to convene a forum in which critical care physicians from a number of hospitals across New York City could frankly discuss their experiences with implementation of crisis standards of care (CSC). The Johns Hopkins Center for Health Security, in collaboration with New York City Health + Hospitals, convened a virtual working group in October 2020 consisting of 15 New York City intensive care unit (ICU) directors.’

Major themes discussed and suggestions moving forward are contained in the 23-page report.

Read here (The Johns Hopkins Center for Health Security, Nov 24, 2020) 

Scientists are puzzling over one crucial number as they evaluate the Oxford-AstraZeneca coronavirus vaccine

‘The Oxford-AstraZeneca vaccine candidate is given to people as two doses, at least one month apart. The trial data, which comes from late-stage studies in the UK, Brazil and South Africa, suggests that the vaccine is 62% effective if people get two full doses, but 90% effective when they get a half-strength version of the first dose. The information was provided in a press release and hasn't been published in a peer-reviewed journal. AstraZeneca and Oxford said they're submitting the results for review and publication.’

Read here (Business Insider, Nov 24, 2020)

China and Russia are using coronavirus vaccines to expand their influence. The US is on the sidelines

“Global health and pharmaceutical interventions are getting sucked into balance-of-power politics,” said David Fidler, senior fellow for global health at the Council on Foreign Relations. “For the U.S., this creates geopolitical nightmares, because we are not in the game.” Beijing and Moscow are marshaling the vast powers of their states to develop vaccines for domestic and international use, accompanied by grand claims of scientific and manufacturing prowess. There are critical questions about safety and efficacy — or even how much each country can produce. But, for the moment, those questions are overshadowed in a seller’s market.

Read here (Washington Post, Nov 24, 2020)

Has capitalism turned the COVID-19 emergency into a disaster?

‘Exploit it’ - Protect the People or the Profit? ‘We were in a crisis before COVID-19 - a crisis of capitalism. Join Ali Rae in this first episode of “Al Hail The Lockdown” - a 5 part series exploring the complexities of our global response to the COVID-19 pandemic. In this episode, Ali speaks with filmmaker and activist Astra Taylor, economist Aditya Chakrabortty and economic sociologist Linsey McGoey about disaster capitalism, philanthro-capitalism and how the structures of capitalism have left us ill-equipped to deal with the fallout of COVID-19.’

View here (Aljazeera, Nov 24, 2020) 

Moderna's chief medical officer says that vaccine trial results only show that they prevent people from getting sick — not necessarily that recipients won't still be able to transmit the virus

‘Moderna Chief Medical Officer Tal Zaks told Axios that the public should not "over-interpret" the vaccine trial results to assume life could go back to normal after adults are vaccinated. "They do not show that they prevent you from potentially carrying this virus transiently and infecting others," Zaks told Axios.  While he believes, based on the science, that it's likely that vaccine does prevent transmission, but said there's still no solid proof of that yet. "I think it's important that we don't change behavior solely on the basis of vaccination," he said.’

Read here (Business Insider, Nov 24, 2020)

A tale of two economies: Stephen Roach

‘As financial markets celebrate the coming vaccine-led boom, the confluence of epidemiological and political aftershocks has pushed us back into a quagmire of heightened economic vulnerability. In Dickensian terms, to reach a “spring of hope,” we first must endure a “winter of despair.”...

‘With COVID-19 still raging – and rates of infection, hospitalization, and death now spiraling out of control (again) – the near-term risks to economic activity have tipped decidedly to the downside in the United States and Europe. The combination of pandemic fatigue and the politicization of public health practices has come into play at precisely the moment when the long anticipated second wave of COVID-19 is at hand.

‘Unfortunately, this fits the script of the dreaded double-dip recession that I warned of recently. The bottom-line bears repeating: Apparent economic recoveries in the US have given way to relapses in eight of the 11 business cycles since World War II. The relapses reflect two conditions: lingering vulnerability from the recession, itself, and the likelihood of aftershocks. Unfortunately, both conditions have now been satisfied.’

Read here (Project Syndicate, Nov 24, 2020)

Qantas CEO Alan Joyce says proof of Covid-19 vaccination will be a condition of international air travel

‘Proof of COVID-19 vaccination will be a non-negotiable condition of international air travel, according to the Qantas CEO Alan Joyce. Anti-vaxxers will be grounded in the brave new world, with Mr Joyce confirming vaccination will be a requirement to fly internationally.

‘Mr Joyce has repeatedly warned that international air travel won’t resume until there’s a vaccine available for staff and travellers, but on Monday night he went a step further, telling A Current Affair host Tracy Grimshaw that as soon as a vaccine becomes available it will be a condition of travel. “For international travellers, we will ask people to have a vaccination before they get on the aircraft,’’ he said.’

Read here (News.com, Nov 23, 2020)

China pushes for QR code based global travel system

‘Chinese President Xi Jinping has called for a "global mechanism" that would use QR codes to open up international travel. "We need to further harmonise policies and standards and establish 'fast tracks' to facilitate the orderly flow of people," he said. The codes will be used to help establish a traveller's health status. But Human Rights advocates warn that the codes could be used for "broader political monitoring and exclusion".’

Read here (BBC, Nov 23, 2020)

MMA says private healthcare underutilised in battle against Covid-19

‘The Malaysian Medical Association (MMA) has called on the government to incorporate private healthcare in its fight against Covid-19, saying that the sector's capabilities are being underutilised. "Our government healthcare facilities should not be taking on this battle all on its own. Private healthcare, an important component in our country’s overall healthcare system, can be an added strength in managing Covid-19 but is still underutilised.’

Read here (Malaysiakini, Nov 23, 2020)

A larger, more sinister pandemic lurks beneath Covid-19

‘More than one in five Americans hospitalised with COVID-19 also contracts a bacterial infection. Absent effective antibiotics, those lucky enough to beat the coronavirus might die at the hands of these not-so-novel pathogens. 

‘Unfortunately, the pipeline of new antibiotics is running dry. Less than 100 years after the development of penicillin, drug-resistant superbugs are threatening to gain the upper hand in our fight against bacterial infections.Superbugs already take an enormous toll on health-care systems around the world. About 700,000 people globally die each year due to antimicrobial resistance (AMR). Without new and better treatments, that figure could rise to ten million by 2050.’

Read here (Channel News Asia, Nov 23, 2020)

The efficacy of the Sputnik V vaccine is 91.4%, based on the second interim analysis

‘The Sputnik V vaccine is based on a well-studied human adenoviral vector platform that has proven safe and effective with no long-term side effects in more than 250 clinical trials globally conducted during the past two decades - while the history of the use of human adenoviruses in vaccine development began in 1953. More than 100,000 people have received approved and registered drugs based on human adenoviral vectors. The uniqueness of the Russian vaccine lies in the use of two different human adenoviral vectors which allows for a stronger and longer-term immune response as compared to the vaccines using one and the same vector for two doses.’

Read here (Sputnik V, Nov 23, 2020)

Is emergency use authorisation the best way to get a Covid-19 vaccine to the public?

‘While an emergency use authorization may be the speediest way for public health officials to begin a vaccination campaign, it may not end up shaving that much time off of a more traditional route to government approval. Using a different expedited process, the FDA cleared a novel Ebola vaccine in just six months. Polls have shown that many Americans are wary of getting a COVID-19 vaccine. Other paths toward granting official approval to COVID-19 vaccines may get vaccines to the public almost as quickly as emergency use authorization can—while providing the public with greater reassurance that those vaccines are safe and effective.’

Read here (Bulletin of the Atomic Scientists, Nov 23, 2020)

Oxford vaccine: How did they make it so quickly?

‘Ten years' vaccine work achieved in about 10 months. Yet no corners cut in designing, testing and manufacturing... They are two statements that sound like a contradiction, and have led some to ask how we can be sure the Oxford vaccine - which has published its first results showing it is highly effective at stopping Covid-19 - is safe when it has been made so fast. So, this is the real story of how the Oxford vaccine happened so quickly.’

Read here (BBC, Nov 23, 2020)

Coronavirus vaccine hesitancy in Black and Latino communities

‘COVID Collaborative, Langer Research, UnidosUS and the NAACP conducted a poll on attitudes and impacts of COVID-19 vaccine hesitancy and resistance in the Black and Latinx communities. The report summarizes these findings and highlights key areas of focus for policy makers, health care professionals, and others working to increase vaccine uptake.’

Read here (Covid Collaborative, Nov 23, 2020)

Why emergency Covid-vaccine approvals pose a dilemma for scientists

‘Immunizations are speeding towards approval before clinical trials end, but scientists say this could complicate efforts to study long-term effects...

‘Once a vaccine is granted emergency approval, there is pressure on developers to offer the immunization to trial participants who received a placebo. But if too many people cross over to the vaccine group, the companies might not have enough data to establish long-term outcomes, such as safety, how long vaccine protection lasts and whether the jab prevents infection or just the disease.

“It’s a real vaccine-development dilemma,” says Klaus Stöhr, who formerly headed vaccine design at the pharmaceutical company Novartis in Cambridge, Massachusetts, and is now retired. Still, Stöhr thinks that the vaccine should be granted emergency-use authorization, because its effectiveness has been established and there is a dire need.’

Read here (Nature, Nov 23, 2020)

Coronavirus vaccines face trust gap in Black and Latino communities, study finds

‘If offered a coronavirus vaccine free of charge, fewer than half of Black people and 66 percent of Latino people said they would definitely or probably take it, according to a survey-based study that underscores the challenge of getting vaccines to communities hit hard by the pandemic... Perhaps its most sobering findings: 14 percent of Black people trust that a vaccine will be safe, and 18 percent trust that it will be effective in shielding them from the coronavirus. Among Latinos, 34 percent trust its safety, and 40 percent trust its effectiveness.’

Read here (Washington Post, Nov 23, 2020)

Doctors say CDC should warn people the side effects from Covid vaccine shots won’t be ‘a walk in the park’

‘The CDC must be transparent about the side effects people may experience after getting their first shot of a coronavirus vaccine, doctors urged during a meeting Monday with CDC advisors. Dr. Sandra Fryhofer said that both Pfizer’s and Moderna’s Covid-19 vaccines require two doses and she worries whether her patients will come back for a second dose because of potentially unpleasant side effects after the first shot. Both companies acknowledged that their vaccines could induce side effects that are similar to symptoms associated with mild Covid-19, such as muscle pain, chills and headache.’

Read here (CNBC, Nov 23, 2020)

When will the Covid-19 pandemic end? Could be 2022 or beyond, says McKinsey & Co

‘Our estimate is based on the widest possible reading of the current scientific literature and our discussions with public-health experts in the United States and around the world. It’s possible that unforeseen developments such as significantly more infections than expected this winter could lead to earlier herd immunity. And real downside risk remains, especially with respect to duration of immunity and long-term vaccine safety (given the limited data available so far). Herd immunity might not be reached until 2022 or beyond.’

Read here (McKinsey & Co, Nov 23, 2020)

WHO head has singled out one developing country for its success in managing the coronavirus pandemic

‘Thailand’s numbers “speak for themselves,” said Tedros Adhanom Ghebreyesus in closing remarks to the World Health Assembly, which took place this week. Thailand was the first country outside China to report a case of COVID-19, but to date it has counted fewer than 4,000 cases and just 60 fatalities, despite having a population of 70 million and one of the world’s biggest and most tightly packed cities in Bangkok. By comparison, the U.K., with a population of about 68 million, has had 1.3 million cases and 51,396 fatalities, according to data aggregated by Johns Hopkins University.’

Read here (Market Watch, Nov 23, 2020)

Puzzling, often debilitating after-effects plaguing COVID-19 "long-haulers"

‘It's not unusual for viruses to cause aftereffects, but as you'll hear tonight, doctors tell us they've never seen anything like this. While researchers around the world are scrambling to figure out what's happening, Mount Sinai Hospital here in New York opened one of the first centers to study and treat people with what they're calling "Post-acute COVID Syndrome." The patients we met have a less clinical term - they call themselves "long-haulers." Anderson Cooper interviews some of them.

Read/view here (CBS News, Nov 22, 2020)

Xi says China ready to boost global Covid-19 vaccine cooperation and travel

‘President Xi Jinping said on Saturday (Nov 21) that China is ready to step up global Covid-19 vaccine cooperation, and called for better international coordination on policies to facilitate movement of people.

‘Pharmaceutical companies and research centres around the world are working on potential Covid-19 vaccines, with large global trials of several of the candidates involving tens of thousands of participants underway. China has five home-grown candidates undergoing Phase III trials. With that [global movement] in mind, Mr Xi said China would propose the creation of a mechanism by which travellers' coronavirus test results were recognised internationally through digital health codes.’

Read here (Straits Times, Nov 20, 2020)

After coronavirus: Our relationship with meat and the next pandemic

‘All pandemics in recorded human history have come via the animal kingdom. With mutations abounding and our interaction with wildlife widening, when are we finally going to address the sick animal in the room?...

‘To be precise, three out of four of those "new diseases" come from animals, and the frequency with which they have emerged has been accelerating for over 40 years... [Delia] Randolph was the lead author of a joint International Livestock Research Institute and UNEP report published in July looking into the reasons for this acceleration. Research from dozens of scientists spanning the globe came to one conclusion: human behaviour, i.e., the way we interact with and consume animals, is the main driver increasing the prevalence of zoonotic disease. 

‘The report lists seven "human-mediated factors" behind the emergence, with numbers one through three as follows: 1) increasing human demand for animal protein, 2) unsustainable agricultural intensification, 3) increased use and exploitation of wildlife.’

Read here (DW, Nov 20, 2020)

Inside Britain's test-and-trace: How the ‘world beater’ went wrong

‘The name NHS Test and Trace sounds like it is one whole service that is part of the NHS. Nothing could be further from the truth. It is a complex web of different programmes, led by the civil service, that have been bolted together rapidly. Private firms play a key role in terms of both testing and tracing, which has meant some of the local expertise available in the NHS, universities and councils has been bypassed.’

Read here (BBC, Nov 20, 2020)

What Covid-19 reveals about twenty-first century capitalism: Adversity and opportunity

‘Twenty-first century capitalism features financialization and monopoly power. A structural perspective of contemporary political economy illuminates how these aspects shape the COVID-19 response. COVID-19 has exposed failures across health care systems, working conditions, supply chains, the depth of inequality, systemic racism, and features of globalization that exacerbate negative outcomes for the many. Examining access to medicines, personal protective equipment and vaccines, inequality and working conditions highlights just some of what is broken and what needs to be fixed. The unsparing challenge and immiseration of COVID-19 offer an opportunity to re-think basic structures of contemporary capitalism and re-imagine a more compassionate future.’

Read here (Springer, Nov 20, 2020)

What the data say about asymptomatic Covid infections

‘Research early in the pandemic suggested that the rate of asymptomatic infections could be as high as 81%. But a meta-analysis published last month1, which included 13 studies involving 21,708 people, calculated the rate of asymptomatic presentation to be 17%...Byambasuren’s review also found that asymptomatic individuals were 42% less likely to transmit the virus than symptomatic people.’

Read here (Nature, Nov 20, 2020)

AstraZeneca Covid-19 vaccine candidate shows promise among elderly in trials

‘A potential Covid-19 vaccine developed by AstraZeneca and Oxford University produced a strong immune response in older adults, giving hope it may protect some of those most vulnerable to the disease, data from mid-stage trials showed. The data, reported in part last month but published in full in The Lancet medical journal on Thursday (Nov 19), suggest that those aged over 70 - who are at higher risk of serious illness and death from Covid-19 - could build robust immunity to the disease, researchers said.

"The robust antibody and T-cell responses seen in older people in our study are encouraging," said Dr Maheshi Ramasamy, a consultant and a co-lead investigator at the Oxford Vaccine Group.’

Read here (Straits Times, Nov 20, 2020)

Almost a million people inoculated with Chinese Covid-19 vaccine: Sinopharm

‘Nearly a million people have taken an experimental coronavirus vaccine developed by Chinese company Sinopharm, the firm said, although it has not yet provided any clear clinical evidence of efficacy. China has been giving experimental Covid-19 vaccines to people including state employees, international students and essential workers heading abroad since July. 

‘Sinopharm's chairman told media this week that nearly a million people have now received their vaccine for emergency use, though he did not provide a specific figure. "We have not received a single report of severe adverse reaction, and only a few had some mild symptoms," Mr Liu Jingzhen said in an interview re-published by the state-owned firm on Wednesday (Nov 18).’

Read here (Straits Times, Nov 20, 2020)

WHO advises against remdesivir for COVID-19 treatment

‘The anti-viral drug remdesivir should not be used to treat COVID-19 patients no matter how severe their illness as it has "no important effect" on survival chances, the World Health Organization said on Friday (Nov 20).

‘Scratching one of the few treatments that had shown some initial promise in severe patients, a WHO Guideline Development Group (GDG) of international experts said there was "no evidence based on currently available data that it does improve patient-important outcomes".’

Read here (Channel News Asia, Nov 20, 2020) 

Evaluating Covid risk on planes, trains and automobiles

‘Many transit companies have established frequent cleaning routines, but evidence suggests that airborne transmission of the novel coronavirus poses a greater danger than surfaces. The virus is thought to be spread primarily by small droplets, called aerosols, that hang in the air and larger droplets that fall to the ground within six feet or so. Although no mode of public transportation is completely safe, there are some concrete ways to reduce risk, whether on an airplane, train or bus—or even in a shared car.’

Read here (Scientific American, Nov 19, 2020)

Three Australian kids baffle doctors after developing Covid antibodies without ever testing positive: Study published in Nature Communications

‘The kids – aged six, seven and nine – took the COVID-19 test and the results were negative. “It was jaw-droppingly amazing because they'd spent a week and a half with us while we were COVID-positive,” added the mother. While two kids had mild symptoms, one daughter remained completely asymptomatic. They were tested again, just to get negative results. This continued for several weeks, until everyone in the family tested negative.

‘What surprised the doctors was when the results came negative despite the polymerase chain reaction (PCR) tests of the kids showing antibodies of Sars-CoV-2. This definitely caused curiosity as the kids never tested positive for the virus. While the researchers are keen to do a further study on the immune response of the kids, paediatrician Shidan Tosif from the University of Melbourne said, “The fact these children were able to shut down the virus and without even showing a positive test result suggests they have some level of their immune system which is able to respond and deal effectively with the virus, without them ever becoming very unwell.”

Read here (Yahoo News, Nov 19, 2020)  

The end of the pandemic is now in sight

‘Both vaccines, from Moderna and from Pfizer’s collaboration with the smaller German company BioNTech, package slightly modified spike-protein mRNA inside a tiny protective bubble of fat. Human cells take up this bubble and simply follow the directions to make spike protein. The cells then display these spike proteins, presenting them as strange baubles to the immune system. Recognizing these viral proteins as foreign, the immune system begins building an arsenal to prepare for the moment a virus bearing this spike protein appears... This overall process mimics the steps of infection better than some traditional vaccines, which suggests that mRNA vaccines may provoke a better immune response for certain diseases...

‘All of this is how mRNA vaccines should work in theory. But no one on Earth, until last week, knew whether mRNA vaccines actually do work in humans for COVID-19. Although scientists had prototyped other mRNA vaccines before the pandemic, the technology was still new. None had been put through the paces of a large clinical trial. And the human immune system is notoriously complicated and unpredictable. Immunology is, as my colleague Ed Yong has written, where intuition goes to die. Vaccines can even make diseases more severe, rather than less. The data from these large clinical trials from Pfizer/BioNTech and Moderna are the first, real-world proof that mRNA vaccines protect against disease as expected. The hope, in the many years when mRNA vaccine research flew under the radar, was that the technology would deliver results quickly in a pandemic. And now it has.’

Read here (The Atlantic, Nov 19, 2020)

Sinopharm JVCo to sponsor 10,000 doses of Covid-19 vaccine for Malaysian frontliners

‘China National Pharmaceutical Group (Sinopharm), through GI Healthcare Resources Sdn Bhd — a joint-venture company (JVCo) with local investors — has agreed to sponsor 10,000 doses of the former's Covid-19 vaccine for Malaysian frontliners.

‘The sponsorship was agreed upon yesterday via a meeting between Malaysian officials, led by Home Minister Datuk Seri Hamzah Zainuddin and Health Minister Datuk Dr Adham Baba, and Sinopharm's chairman Liu Jingzhen via video conferencing.’

Read here (The Edge, Nov 19, 2020)

US states that imposed few restrictions now have the worst outbreaks

‘Coronavirus cases are rising in almost every U.S. state. But the surge is worst now in places where leaders neglected to keep up forceful virus containment efforts or failed to implement basic measures like mask mandates in the first place, according to a New York Times analysis of data from the University of Oxford. Using an index that tracks policy responses to the pandemic, these charts show the number of new virus cases and hospitalizations in each state relative to the state’s recent containment measures.’

Read here (New York Times, Nov 18, 2020)

The Delinquent Dozen of pandemic profiteers -- A report on billionaire wealth versus community health

‘There are few stories more sordid than the surging wealth gains of the world’s billionaire class during a pandemic when so many have lost their lives, health, and livelihoods. A handful of billionaires and corporations have seen their wealth surge to record levels, in part as a result of their monopoly status and opportunism during the pandemic...

‘Meanwhile, private equity firms have bought up essential businesses in the health care, grocery, and pet care industries, only to aggressively cut costs, skimp on worker safety, and load companies up with debt to boost their own profits. Hundreds of thousands of essential workers employed by these companies have remained vulnerable and exposed. These frontline workers risk their lives every day to do the work that increases already obscene corporate wealth.

‘This report focuses on a list of 12 emblematic bad actors. We call them the Delinquent Dozen — corporations that should do significantly more to protect their workers as their owners and executives continue to reap billions.’

Read here (Inequality.org, Nov 18, 2020)

China insists coronavirus can be imported through food, the world disagrees

‘There have been sporadic outbreaks across China, mostly linked to workers dealing with cold-chain imported food. The country said last week that it would ban food imports from countries with coronavirus outbreaks in their production facilities, or whose products were found to contain traces of the virus. Trade partners have bristled at the restrictions targeted at preventing imports of the virus, but China's severe measures should not be hastily written off: its travel bans and mandatory mask-wearing efforts earlier this year have proven prescient.’

Read here (Straits Times, Nov 18, 2020)

What history can teach us about the post-Covid economy (Morningstar, Nov 17, 2020)

‘To investigate the means through which these shifts could happen—and the likelihood that they will—we identified three main ways the coronavirus could shape the economy long after the pandemic has subsided:

• Habits could evolve, causing lasting change in consumer behavior. As an example of the impact of habits, consider the rise of recycling in the United States over the past several decades. This shift was due in part to the advent of Earth Day in 1970 and the nationwide campaign encouraging Americans to "reduce, reuse, recycle." The Environmental Protection Agency reported that 34.7% of municipal solid waste was recycled in 2015, as compared with 6.6% in 1970.
• Fear can make consumers reluctant to engage in certain activities—in this case, fear of the next pandemic (including a COVID-19 resurgence). An instance where fear led to consumer shifts is when research in the 1960s demonstrated the health risks of smoking cigarettes. This led to a permanent reduction in cigarette sales—approximately 42% of U.S. adults smoked in 1964, compared with approximately 19% in 2011.
• Sunk costs, or costs that have already been incurred and cannot be recouped, could change the long-term plans of consumers and firms. A classic example of sunk costs is the Concorde. British and French manufacturers poured such exorbitant sums into developing the aircraft in the 1950s and 1960s that the jet never became profitable over the decades it was commercially available. (This was such a notorious incident that the sunk-cost fallacy is sometimes also referred to as the Concorde fallacy.)

Read here (Morningstar, Nov 17, 2020)

FDA authorises first at-home coronavirus test

‘The Food and Drug Administration has authorized the first prescription at-home coronavirus test, in a long-awaited milestone. The test, developed by Lucira Health, can be used by people who are at least 14 years old when their health provider suspects they have Covid-19, the FDA said late Tuesday. The test can be used on younger people, but in that case a health care provider must collect the sample.

‘The test involves swabbing the inside of the nose, placing the swab in a vial and swirling it before putting the vial in a "test unit." The process gives results in 30 minutes or less. FDA medical device director Jeff Shuren said the test, which can be fully run outside a lab or health care settings, represents a significant step forward.’

Read here (Politico, Nov 17, 2020)

Vaccine rollout could cause US dollar to fall 20% in 2021: Citi

‘The widespread distribution of vaccines to combat the coronavirus pandemic and ongoing monetary easing could cause the U.S. dollar to weaken as much as 20% next year, Citibank said on Monday. “When viable, widely distributed vaccines hit the market, we believe that this will catalyze the next leg lower in the structural USD downtrend we expect,” the U.S. bank said in a research note.’

Read here (Reuters, Nov 17, 2020)

Is the new Covid vaccine our way back to normality? - Video explainer by The Guardian

‘The news this week that the Pfizer/BioNTech Covid-19 vaccine was effective on more than 90% of trial recipients is of huge importance. The efficacy is significantly higher than hoped for and so far there appear to be no safety concerns.

‘The Guardian's health editor, Sarah Boseley, explains that, while this is a major breakthrough, there are still several hurdles to overcome, and restrictions, such as wearing masks, social distancing and remote working, must remain in place for the time being.’

View here (The Guardian, Nov 13, 2020)

Hopes of Covid vaccine for more than 1bn people by end of 2021

‘More than 1 billion people could be immunised against coronavirus by the end of next year with shots from the first two companies to reveal positive results, after the latest vaccine was shown to be nearly 95% effective in trials. The inclusion of high-risk and elderly people in the Moderna trial suggested the vaccine would protect those most vulnerable to the disease, said Peter Openshaw, a professor of experimental medicine at Imperial College London, who described the results as “tremendously exciting”.

‘Though it is more expensive, Moderna’s vaccine could potentially provide a major advantage over Pfizer’s, which requires ultracold freezing between -70C (-94F) and -80C from production facility to patient. Moderna said it had improved the shelf life and stability, meaning its vaccine can be stored for six months at -20C for shipping and long-term storage, and at standard refrigeration temperatures of 2C to 8C for 30 days.’

Read here (The Guardian, Nov 16, 2020)

Covid-19 was present in Italy as early as SEPTEMBER 2019, study of lung cancer screenings shows

‘The Covid-19 virus had been active in Italy months before it was first officially detected, new research has found, raising further questions about the true origins, extent and actual duration of the ongoing pandemic. The new groundbreaking study, conducted by scientists with Milan Institute of Cancer and the University of Siena, was published this week by the Tumori Journal. The research is based on the analysis of blood samples from 959 people, collected during lung cancer screening tests conducted between September 2019 and March 2020.

‘More than 11 percent of the tested – 111 people – turned out to have had coronavirus-specific antibodies. All the tested people were asymptomatic and were not showing any signs of the disease. Some 23 of the positive results date back to September 2019, suggesting that the virus was actually present in the country as early as during last summer – some six months before the pandemic ‘began’ and ‘reached’ Italy.

‘The new research is poking new holes in the already well-battered belief that the novel coronavirus emerged from the Chinese city of Wuhan around December 2019 and that it turned into pandemic in January 2020. The data from Italian researchers is particularly valuable, as it’s based on actual blood samples, as compared to the earlier, less conclusive findings that also suggested that the established pandemic timeline could be wrong.’

Read here (RT, Nov 15, 2020)

Movement control orders are not the way to defeat Covid-19: Academy of Professors Malaysia (APM)

Here are their suggestions in seven parts:

1. Red Zones with more than 40 new daily cases should continue to be under EMCO, but the rest of the country should return to RMCO. Perhaps these acronyms could best be replaced with number codes in order to avoid the misconceptions.
2. The continued detection of localised outbreaks (clusters) should continue. However, since the Covid-19 infection survival rate is 99.9 per cent for healthy people under 70, to achieve an optimal balance between health, social wellbeing, and the economy, the emphasis should be on "focused protection" and "targeted approach" for those at risk while allowing the less vulnerable to work and go to school. (a) Young and healthy adults and children above the age of 12 should be allowed to go back to school and work. (b) People with co-morbidities regardless of age and the elderly should stay at home. (c) People who go to work and school should be taught how to clean themselves and how to approach vulnerable family members when they return home. These measures should be taught on media, at the workplace and at school.
3. As advocated earlier, people should be taught and continually reminded about carrying out the responsibility of protecting themselves against Covid-19 by practicing the 3W and 3C as the daily norms. The public should also be educated on the level of risk of getting an infection from activities so as to avoid the activities that are high risk, for example avoiding bars, indoor close contact, meetings and parties, eating in crowded indoor restaurants, etc. Activities outside, with physical distancing, is generally low risk and since we need the sun to produce Vitamin D, exercising outside should be encouraged.
4. That the SOPs need to be well defined, complete and accurate to avoid confusion. For instance, the misunderstanding on the usage of masks during fuelling at petrol stations, and the restriction of travelling together and eating at a table in restaurants, while the group may be from the same household, hence sharing the same living environment and air. Such restrictions may further increase the risk of depression, lethargy, and family discord of being cooped up for too long.
5. That nutritional education on the right food would assist the development of a stronger immune system. Get nutritionists and dieticians on board in the media to tell people what to eat, how to prepare and cook and when to eat is as important as showing people how to exercise in the mornings.
6. The creation of platforms for people with mental health issues to reach out to either at the university, healthcare, organisational or even individual level and if possible make it free so that anyone can get help when needed.
7. That the message of keeping the vulnerable and high risk groups safe should be constantly reaffirmed and resonated to the public via media and to communities. It is important to make sure that people above 70 and anyone who has chronic diseases do not get infected.

Read here (New Straits Times, Nov 14, 2020)

Modelling suggests Covid-19 cases to rise steadily unless more is done

‘The number of Covid-19 cases in Malaysia is expected to rise steadily over the next four weeks unless stronger interventions are introduced to curtail its spread, according to projections by Imperial College London’s MRC Centre for Global Infectious Disease Analysis.

‘Its model estimated that the number of Covid-19 infections in Malaysia is projected to increase steadily to about 7,467 infections per day by Dec 8 if no new measures are introduced to curb its spread. It also projected there would be about 16 Covid-19 deaths per day.

‘This is an increase from the model’s estimate of 4,413 infections per day as of Nov 10. The figure is vastly different from the official tally of 869 confirmed cases that day due to the model’s particular approach to account for underreporting of Covid-19 cases.’

Read here (Malaysiakini, Nov 14, 2020)

The Chinese model against Covid-19: A total war of the people, for the people, by the people

‘Wang Hui, an intellectual leader of the so-called New Left movement, offers an interesting alternative explanation [on China's Covid response]... Wang, by the way, is quite well-known among China specialists in the West. Harvard University Press is scheduled to publish an English edition of his multivolume The Rise of Modern Chinese Thought.

‘...he argued that Beijing utilised the old Maoist-Leninist models of the people’s war and total war, to mobilise the entire nation – horizontally across the medical and scientific professions, and up and down the ranks from the top Chinese leadership to humblest local neighbourhood units. Everything was put on hold, even the all-important economy, while the nation’s resources were devoted to a single task.’

Read here (South China Morning Post, Nov 13, 2020) 

World's top intensive care body advises against remdesivir for sickest Covid patients

‘Antiviral remdesivir should not be used as a routine treatment for COVID-19 patients in critical care wards, the head of one of the world's top bodies representing intensive care doctors said, in a blow to the drug developed by U.S. firm Gilead GILD.O.

‘Remdesivir, also known as Veklury, and steroid dexamethasone are the only drugs authorised to treat COVID-19 patients across the world. But the largest study on remdesivir’s efficacy, run by the World Health Organization (WHO), showed on Oct. 15 it had little or no impact, contradicting previous trials.

‘In light of the new interim data from the WHO’s Solidarity trial “remdesivir is now classified as a drug you should not use routinely in COVID-19 patients,” the President of the European Society of Intensive Care Medicine (ESICM), Jozef Kesecioglu, said in an interview with Reuters.’

Read here (Reuters, Nov 13, 2020) 

WHO-backed probes move forward to try to shed light on early days of coronavirus

‘Among the work laid out is further investigation into wild animals traded at Wuhan’s Huanan market, where a number of the first known patients worked and shopped. The virus is believed to have originated in bats before passing to humans, likely through an intermediary animal, but it remains unclear whether this crossover happened at the market or outside it, according to the WHO. So far that market has proved a dead-end for animal clues: of the 336 samples from “frozen animal carcasses” that were tested in the market, none were positive for the virus, according to the November 5 report, which updated known figures on animal sampling.

‘Other research will involve looking back before December 2019 to review hospital records, death registers and disease surveillance data, and test stored blood samples to find any cases that appeared before those that are already known. Unpublished government records obtained by the South China Morning Post indicated that Covid-19 cases were identified in Hubei province as early as November 17.’

Read here (South China Morning Post, Nov 13, 2020) 

Covid-19: Politicisation, “corruption,” and suppression of science

‘When good science is suppressed by the medical-political complex, people die

‘Politicians and governments are suppressing science. They do so in the public interest, they say, to accelerate availability of diagnostics and treatments. They do so to support innovation, to bring products to market at unprecedented speed. Both of these reasons are partly plausible; the greatest deceptions are founded in a grain of truth. But the underlying behaviour is troubling.

‘Science is being suppressed for political and financial gain. Covid-19 has unleashed state corruption on a grand scale, and it is harmful to public health. Politicians and industry are responsible for this opportunistic embezzlement. So too are scientists and health experts. The pandemic has revealed how the medical-political complex can be manipulated in an emergency—a time when it is even more important to safeguard science.’

Read here (BMJ, Nov 13, 2020)

‘No one is listening to us’

‘More people than ever are hospitalised with COVID-19. Health-care workers can’t go on like this...

‘For many health-care workers, the toll of the pandemic goes beyond physical exhaustion. COVID-19 has eaten away at the emotional core of their work. “To be a nurse, you really have to care about people,” Neville said. But when an ICU is packed with COVID-19 patients, most of whom are likely to die, “to protect yourself, you just shut down. You get to the point when you realise that you’ve become a machine. There’s only so many bags you can zip.”...

‘As hard as the work fatigue is, the “societal fatigue” is harder, said Hatton, the Utah pulmonary specialist. He is tired of walking out of an ICU where COVID-19 has killed another patient, and walking into a grocery store where he hears people saying it doesn’t exist. Health-care workers and public-health officials have received threats and abusive messages accusing them of fearmongering. They’ve watched as friends have adopted Donald Trump’s lies about doctors juking the hospitalization numbers to get more money. They’ve pleaded with family members to wear masks and physically distance, lest they end up competing for ICU beds that no longer exist. “Nurses have been the most trusted profession for 18 years in a row, which is now bullshit because no one is listening to us,” Neville said.’

Read here (The Atlantic, Nov 13, 2020)

‘Lean into loneliness like it is holding you’ – A poetic reflection on life in lockdown

‘The audiovisual poem How to Be Alone (2010) was a viral hit for the Canadian musician and poet Tanya Davis and the Canadian filmmaker Andrea Dorfman. Their sequel How to Be at Home updates the original for our age of COVID-19 lockdown, pairing Dorfman’s charming animations – a distinctive melding of stop-motion and illustration – with Davis’s lyrical musings on the isolation that she and much of the rest of the world has endured over the past eight months. The resulting short is an artful – and, depending on your current degree of solitude, perhaps cathartic – meditation on the many conflicting emotions inspired by being forced to spend time at home during a crisis.’

View here (Aeon, Nov 12, 2020)

Early and systematic tracking of high-risk contacts helped Uttar Pradesh step up the fight against Covid-19

‘The state of Uttar Pradesh continues to be one of the high-burden states and reported 474 054 cases and 6940 fatalities as of 27 October 2020. Being the most populous state of India, with a population of more than 199 812 341 (as per 2011 census), its fight against COVID-19 has been particularly challenging. When the cases surged post lifting of restrictions, as part of its surveillance response activities with support from WHO, the state government put in place a mechanism to evaluate the status and quality of contact tracing to guide policy level decision making for an informed public health response.

‘The World Health Organization (WHO)- National Public Health Surveillance Project (NPSP) team of medical officers along with 800 field monitors undertook a massive exercise to assess the status and quality of contact tracing amongst the 58 000 laboratory-confirmed cases of COVID-19 in 75 districts across the state during two weeks from 01-14 August 2020...

‘This massive effort led to identification of several cases that would not have been otherwise detected and helped in containing the further spread of the disease. Quality assessment exercise also enabled improved data collection and allowed authorities to make evidence-based decisions on containment measures. The government also deployed more teams to strengthen surveillance activities in districts with high-case load.

‘Acknowledging the key role of contact tracing as an essential public health tool for controlling disease outbreaks, Dr Roderico Ofrin, WHO Country Representative to India shares that systematic tracking of contacts through a proper mechanism is key, along with a well-trained health workforce to implement the surveillance activities.

“The UP government’s strategic response to COVID-19 by stepping up contact tracing efforts is exemplary and can serve as a good example for other states”, he adds.’

Read here (WHO, Nov 12, 2020)

Even with a vaccine, Covid-19 will last for years in the US, expert says

‘I think, even if the vaccine or several vaccines are invented in the next few months, which is likely, we still have challenges in manufacturing, distributing and persuading the public to accept the vaccine. And those challenges will take about a year. And, meanwhile, the virus is still spreading, and it will continue to spread until we reach a threshold of about 40 to 50 percent of Americans who are infected. Right now, we're only at about 10 percent. That threshold is known as the herd immunity threshold.

‘So, that will take us into 2022. So, from my perspective, the first period during which we're confronting the biological and epidemiological impact of the virus, and we're living in a changed world, wearing masks, physical distancing, school closures, and so on, will last until sometime in 2022. And then we're going to begin a second period, when we are recovering from the psychological, social and economic shock of the virus. And this has been seen for thousands of years with other epidemics. And that will take a couple of years for us to rebuild our economy and recover.

‘And so, sometime in 2024, I think, life will slowly begin to return to normal, with some persistent changes.’

Read here (PBS News Hour, Nov 12, 2020)

One in 5 Covid-19 survivors will develop mental illness, a new study found—So we asked an expert why

‘Covid-19 is an infectious disease that causes respiratory illness, but its effects can go way beyond that. A large study from Oxford University in the UK found that survivors are at a higher risk of developing mental illness, such as anxiety and depression. They are also more likely to develop dementia, according to the research, which was published in The Lancet Psychiatry on November 9.

‘The researchers analyzed electronic health records of 69 million people in the US, including more than 62,000 people who had COVID-19. They found that 20% of those infected with the coronavirus were diagnosed with a psychiatric disorder within 90 days—about twice as likely as for other groups of patients with other illnesses in the same time frame.’

Read here (Health, Nov 11, 2020)

Stanford study suggests indoor dining presents huge Covid-19 infection risk

‘According to the New York Times, the study followed the movement of 98 million people to and from indoor public spaces, then calculated traffic to each spot visited as well as how long people stay and each venue’s square footage. Using the area’s infection rate, they then used “standard infectious disease assumptions” to determine how the illness spread across cities.

‘Stanford computer scientist Jure Leskovec, the senior author of the report, tells the Times that “restaurants were by far the riskiest places” for new infections, “about four times riskier than gyms and coffee shops, followed by hotels,” he says. It’s news that jibes with another recent study from the Centers for Disease Control and Prevention (CDC), which said in September that a study of adults across 11 U.S. cities who tested positive for the novel coronavirus were twice as likely to have dined out within the last two weeks than those who tested negative.’

Read here (Eater San Francisco, Nov 11, 2020)

Breaking down Moderna’s Covid-19 patent pledge: Why did they do it?

‘Last month, Moderna Therapeutics, one of the global leaders in the race to produce a COVID-19 vaccine using mRNA, made the following statement regarding enforcement of its patents: “We feel a special obligation under the current circumstances to use our resources to bring this pandemic to an end as quickly as possible. Accordingly, while the pandemic continues, Moderna will not enforce our COVID-19 related patents against those making vaccines intended to combat the pandemic. Further, to eliminate any perceived IP barriers to vaccine development during the pandemic period, upon request we are also willing to license our intellectual property for COVID-19 vaccines to others for the post pandemic period.”

‘This post examines why Moderna made this patent pledge by examining its mRNA technology, go-to-market status, patent landscape, and market position.’

Read here (IP Watchdog, Nov 11, 2020)

Covid outbreak data on US carrier shows a plethora of initial symptoms among the symptomatic, only 5.3% fever : NEJM

‘Among the crew members who had symptomatic Covid-19 (confirmed or suspected), headache was the most common symptom reported at any point during illness (occurring in 68.0%), followed by cough (59.5%), nasal or sinus congestion (43.8%), and altered sense of taste or smell (42.3%) (Figure 3). The predominant symptoms reported at the onset of illness were cough (32.8%), headache (31.0%), and altered sense of taste or smell (24.1%). Shortness of breath at any point during illness was reported by 20.3% of the crew members with symptomatic cases, and 7.0% noted shortness of breath as an initial presenting symptom. In addition, 26.2% of the crew members with symptomatic Covid-19 reported chest pain or chest pressure at some point during their illness. Fever was reported as an initial presenting symptom by 5.3% of the crew members with symptomatic Covid-19, and fever at any point during illness was reported by 13.2%. Measured temperature readings showed that 2.8% of the crew members who had Covid-19 had a recorded temperature of 100.0°F or above, as compared with 0.3% of the crew members who did not have Covid-19. Among the crew members with Covid-19 for whom pulse oximetry data were available, approximately 0.5% had readings below 95% while breathing ambient air, with 0.08% below 94% and none below 90%.’

Read here (New England Journal of Medicine, Nov 11, 2020) 

How Pfizer Covid-19 vaccine could be cold comfort for some Asian nations

‘With tropical heat, remote island communities and a dearth of ultra-cold freezers, many Asian countries aren't betting on Pfizer's experimental vaccine solving their COVID-19 crisis any time soon. The world cheered on Monday (Nov 9) when Pfizer announced its shot, jointly developed with BioNTech SE, was more than 90 per cent effective based on initial trial results. Yet health experts cautioned that the vaccine, should it be approved, was no silver bullet - not least because the genetic material it's made from needs to be stored at temperatures of minus 70 degrees Celsius or below.’

Read here (Channel News Asia, Nov 10, 2020) 

Who are the candidates in the Covid-19 vaccine race?

‘Almost 200 Covid-19 vaccine candidates are being studied by scientists around the world. Of these, 44 are already in clinical trials, which means they are being tested on humans. The Straits Times highlights some of the prominent candidates in the Covid-19 vaccine race.’

Read here (Straits Times, Nov 10, 2020)

How Trump sold failure to 70 million people

‘The president convinced many voters that his response to the pandemic was not a disaster. The psychology of medical fraud is simple, timeless, and tragic... The narratives and tactics Trump used to persuade people to trust him as a sole beacon of truth—amid a sea of corrupt, lying scientists and doctors—draw on those of cult leaders, self-proclaimed healers, and wellness charlatans as much as those of authoritarian demagogues. They have proved effective over centuries...

“Reason is not involved in the process.” The draw is the personality of the healer, and “subsequent success is ensured by mass suggestion.”... If the nation’s public-health and scientific communities assume that the appeal of a quack was some transient aberration—something that will end when Trump is out of office, and that can be remedied with yet more facts—then the Biden administration will fail to reach millions of Americans, no matter how soundly it recites statistics. Its warnings and mandates will go unheeded and become fodder for charismatic outsiders who tell people what they want to hear...

‘There are ways to serve as a confident, optimistic leader without making up nonsensical promises. Hope can be conferred with promises to take care of people, and to be there for them. Reassurance can be offered by guaranteeing that no one will go into debt because they had to go to the hospital, and that people will have paid sick leave and job security so they can stay at home when necessary. If the public-health community does not do more to give people hope and reassurance in the face of this disaster, it will see people defect to those who will—even when they know the promises are too good to be true.’

Read here (The Atlantic, Nov 10, 2020)

Independent UN experts decry Covid vaccine hoarding: ‘No one is secure until all of us are secure’

‘The only way to fight the COVID-19 crisis is to make affordable vaccines available to everyone, independent UN human rights experts said on Monday, underscoring that in an interconnected and interdependent world, “no one is secure until all of us are secure”...  “This pandemic, with its global scale and enormous human cost, with no clear end in sight, requires a concerted, human-rights based and courageous response from all States”, four UN experts together with members of a human rights working group said in a statement on universal access to vaccines.’

Read here (UN News, Nov 9, 2020)

First ‘milestone’ vaccine offers 90% protection

‘The first effective coronavirus vaccine can prevent more than 90% of people from getting Covid-19, a preliminary analysis shows. The developers - Pfizer and BioNTech - described it as a "great day for science and humanity". Their vaccine has been tested on 43,500 people in six countries and no safety concerns have been raised. The companies plan to apply for emergency approval to use the vaccine by the end of the month.’

Read here (BBC, Nov 9, 2020) 

Could a cheap iodine mouthwash really help to beat Covid?

‘We all probably have a sense-memory of iodine: the blood-like drop to purify a camping can of stream-water or the inky dab with which your grandmother stained your grazed knee. It feels like an old-fashioned, primitive home remedy, yet could it also be an intriguing new weapon against our most modern threat: coronavirus?

‘One of the world’s leading authorities on infection in the mouth and nose believes the answer is yes. Stephen Challacombe is a professor of oral medicine at King’s College London, with a specialism in the immunology of the mucous membranes. His decades of experience meant that when the pandemic hit, his mind went immediately to one — literal — solution. Iodine mouthwash. “Yes. I have no doubt that this should be used,” Challacombe says, “and had it been, it would have saved lives.”

‘Bottles of this form of iodine, called povidone-iodine, also known by the most common brand Betadine, used to be on sale in British chemists, before the public began to favour fluoride rinses. It is still popular as a sore-throat gargle in many European countries, America, Australia and Far East countries such as Japan. When the pandemic struck, Challacombe and his colleagues wrote to the British Dental Journal reminding the scientific world of its potential.’

Read here (King's College Journal, Nov 9, 2020)

How Biden plans to change the US pandemic response

‘President-elect Joe Biden and Vice President-elect Kamala Harris say they will move the US Covid-19 pandemic response in a dramatically different direction... Here are five ways Biden says the US coronavirus response will change when he's President. (1) Increased testing and contact tracing. (2) Additional investment in vaccines and treatments. (3) Mandatory masks and more PPE. (4) A push for 'clear, consistent, evidence-based guidance'. (5) Rejoining WHO and searching for future threats.

‘There were dauntingly high new case numbers last week, and by the time Biden takes office January 20, the influential University of Washington Institute of Health Metrics and Evaluation model projects there will be more than 372,000 Covid-19 deaths -- that's 135,000 more than the current total...’

Read here (CNN, Nov 9, 2020)

‘Mutant coronavirus’ seen before on mink farms, say scientists

‘The coronavirus mutation causing concern in Denmark has arisen before in mink, scientists have revealed. The mutated virus has been detected retrospectively in mink at a farm in the Netherlands, but it did not spread to humans, said a leading Dutch expert...

‘The genetic data from Denmark was released on an international database a few days ago, with some scientists questioning why it had not been released sooner. "I think that it is most disappointing that the data have only just reached the light of day," said Prof James Wood, head of the department of veterinary medicine at the University of Cambridge, UK...

‘Six countries have reported coronavirus outbreaks at mink farms: the Netherlands, Denmark, Spain, Sweden, Italy and the US.’

Read here (BBC, Nov 9, 2020)

Coronavirus: The Swiss Cheese Strategy -- Tomas Pueyo

‘There are the four layers to stop the spread of the virus: Fences, Bubbles, Contrafection, and Test-Trace-Isolate. None of them is perfect. All have holes that let infections pass. But together they form an impenetrable defence.

‘An infection might be able to pass one layer, or even two. But if there are several, the odds that the infection goes through every layer undetected becomes minuscule. Imagine, for example, that a country has a Fence that catches 80% of infections, no Social Bubbles, Reduced Contagiousness that eliminates 95% of infections, and a test-trace-isolate that neutralizes 50% of infections. Together, these layers catch 99.5% of cases. If the transmission rate R is 3 (the number of people infected by a source), it will be reduced to 0.015! Every infected person only infects an additional 0.015 people, killing the epidemic within a few weeks.’

Also...

• How the US and the EU failed to control the virus, and how comparable countries succeeded.
• How you can make sense of all the necessary measures with one simple idea.
• Why the West’s testing and contact tracing is largely useless — and what they can do about it.
• The questions that journalists and the People must ask politicians to keep them accountable.
• How you can stop the virus in your own community, without the need of your government.

Read here (Medium, Nov 9, 2020) 

Memo for President Biden: Five steps to getting more from science

‘The list of needed actions is long, but here we highlight five that the Biden administration should take swiftly. We call not for a return to business as usual but for fundamental, sometimes counter-intuitive changes that will strengthen the use of science in US policy and by the research community more broadly... (1) Let an oft-overlooked White House office [Office of Science and Technology Policy] lead the pandemic response. (2) Make advisory processes more independent. (3) Expedite scientific-integrity legislation.  (4) Give public universities tough love and lots of support. (5) Refocus science funding.

Read here (Nature, Nov 8, 2020)

Counties with worst virus surges overwhelmingly voted Trump

‘US voters went to the polls starkly divided on how they see President Donald Trump’s response to the coronavirus pandemic. But in places where the virus is most rampant now, Trump enjoyed enormous support. An Associated Press analysis reveals that in 376 counties with the highest number of new cases per capita, the overwhelming majority — 93% of those counties — went for Trump, a rate above other less severely hit areas.

‘The US broke another record in the 7-day rolling average for daily new cases, hitting nearly 90,000. The tally for new cases Thursday was on track for another day above 100,000, with massive numbers reported all around the country, including a combined nearly 25,000 in Texas, Illinois and Florida. Iowa and Indiana each reported more than 4,000 cases as well.

‘Thirty-six percent of Trump voters described the pandemic as completely or mostly under control, and another 47% said it was somewhat under control, according to AP VoteCast, a nationwide survey of more than 110,000 voters conducted for the AP by NORC at the University of Chicago. Meanwhile, 82% of Biden voters said the pandemic is not at all under control.

‘The pandemic was considered at least somewhat under control by slim majorities of voters in many red states, including Alabama (60%), Missouri (54%), Mississippi (58%), Kentucky (55%), Texas (55%), Tennessee (56%) and South Carolina (56%).’

Read here (AP, Nov 6, 2020) 

India tops global survey on Covid-19 vaccination intent; rising hesitancy in many other countries

‘Indians are the keenest on getting vaccinated whenever a Covid-19 vaccine is available, even as people in 10 out of 15 countries showed a growing reluctance about getting vaccinated, according to a global survey. 

‘In the World Economic Forum/Ipsos survey of 18,526 adults from 15 countries, 73 per cent said they would get a Covid-19 vaccine if available, down from 77 per cent in August. While vaccination intent has remained unchanged at 87 per cent in India since August, it has declined in 10 of the 15 countries surveyed, most of all in China, Australia, Spain, and Brazil.

‘Globally, the two main reasons for not wanting to get a Covid-19 vaccine are concerns about side effects (cited by 34 per cent) and concerns about clinical trials moving too fast (cited by another 33 per cent). In India also, 34 per cent respondents.’

Read here (Deccan Herald, Nov 6, 2020)

Covid-19 a ‘perfect storm’ for organ trafficking victims

‘Fewer transplants means a huge unmet demand for organs... Rising inequality pushing disadvantaged to take desperate measures... Social media facilitates trade’

Read here (SciDev, Nov 5, 2020)

China seeks to flip the script on Covid blame game

‘Chinese state media is advancing a possible alternative explanation for the origin of the Covid-19 pandemic, one that claims that the contagion may have first arrived in China from abroad in imported frozen foods. Chinese officials quoted in the reports suggest  “cold chain food contamination” could debunk the widely held belief that the novel coronavirus first emerged from a wet market in the Chinese city of Wuhan, from where it reputedly made its lethal global spread.’  

Read here (Asia Times, Nov 4, 2020) 

Denmark to cull millions of minks over mutated coronavirus

‘Denmark, the world's biggest producer of mink fur, said Wednesday it would cull all of the country's minks after a mutated version of the new coronavirus was detected at its mink farms and had spread to people. The mutation "could pose a risk that future (coronavirus) vaccines won't work the way they should," Prime Minister Mette Frederiksen told a press conference, adding: "It is necessary to cull all the minks."

“The mutated virus could thereby have serious negative consequences for the whole world’s response to the ongoing pandemic,” she said. Danish police estimated that between 15 and 17 million minks would need to be put down. Twelve people are currently registered as infected with a mutated form of the coronavirus in Denmark, according to news wire Ritzau. The mutated virus is reported to respond weakly to antibodies.’

Read here (The Local, Denmark, Nov 4, 2020)

Lung damage found in Covid dead may shed light on ‘long Covid’: Study

‘A study of the lungs of people who have died from COVID-19 has found persistent and extensive lung damage in most cases and may help doctors understand what is behind a syndrome known as ‘long COVID’, in which patients suffer ongoing symptoms for months. “The findings indicate that COVID-19 is not simply a disease caused by the death of virus-infected cells, but is likely the consequence of these abnormal cells persisting for long periods inside the lungs,” said Mauro Giacca, a professor at King’s College London who co-led the work. In a telephone interview, Giacca said that, while his research team found no overt signs of viral infection or prolonged inflammation in other organs, they discovered “really vast destruction of the architecture of the lungs”, with healthy tissue “almost completely substituted by scar tissue”.

Read here (Reuters, Nov 4, 2020)

The wisdom of pandemics

‘Viruses are active agents, existing within rich lifeworlds. A safe future depends on understanding this evolutionary story...

‘Researchers since then have uncovered evidence that pathogens exert ‘the strongest selective pressure to drive the evolution of modern humans’. Among the drivers, look to evidence that prehistoric pandemics played a role in selecting for ancestral traits and behaviours that we recognise as human today. Scientists following another thread in this evolutionary narrative describe viral nucleic acids insinuating themselves into our genetic codes. The biologist David Enard at Stanford University in California and colleagues have concluded that ‘viruses are one of the most dominant drivers of evolutionary change across mammalian and human proteomes’...

‘As we become more deft at exploring the nested, dynamically complex relationships among viruses, bacteria, fungi and ourselves, we’ll come closer to grasping how pandemics emerge from a rupturing and rearranging of these relationships. From this deep linking of Aion with Chronos, we can already see the outlines of the wisdom that pandemics offer us. What we’re beginning to faintly understand is this: if we wish to survive as a species, we must gather all of our knowledge from multiple perspectives – however fragmented and partial – and actively engage in conversations with the world we inhabit and that gives us life. Only then will we begin to understand ourselves, and live up to our name, the wise ones, Homo sapiens sapiens.’

Read here (Aeon, Nov 3, 2020)

Polls reform panel hails govt review of electoral process for Covid-19 era

‘The Electoral Reform Committee (ERC) today welcomed the government's willingness to review create laws concerning elections during the pandemic. Its chairman Tan Sri Abdul Rashid Abdul Rahman said it is high time a comprehensive review be conducted on existing laws for the electoral process, whether it is for by-elections or for a general election. “This is especially to determine if elections can be suspended in times of crises, including those related to health, public disorder, natural disaster, or in situations which threaten national security,” he said in a statement.’

Read here (Malay Mail, Nov 3, 2020)

Winning trust for a vaccine means confronting medical racism

‘Just about every minority group residing in the United States can point to what feels like a reasonable basis for suspicion. For African Americans, there is not only the notorious Tuskegee study, which withheld syphilis treatment from rural Black men, but also experiments that used enslaved women to perfect surgical techniques and studies that tested new drugs in poor neighbourhoods without adequate consent. The Latino community can point to a syphilis study in Guatemala that was even more unethical than the Tuskegee one, and to pharma companies basing tests of the first versions of birth control pills, which caused significant side effects, in Puerto Rico (and also in Haiti). Attempting to pass smallpox to Native Americans via contaminated blankets is an infamous episode in Colonial-era history, and the US government has underfunded the Indian Health Service since its 1955 founding, depriving reservation dwellers of what should have been guaranteed medical care.’

Read here (Wired, Nov 2, 2020)

Daisy Chain: Can a Cornish town adapt to survive another lockdown?

‘When the remote town of St Just, Cornwall, was locked down in March, the small community worried that its economy wouldn't survive. But one town councillor, Daisy Gibbs, rallied an army of volunteers to form 'the Daisy chain', an informal support network to ensure every household in the district had support. Inspired by her imagination and resilience, filmmaker Sky Neal followed the Daisy Chain for seven months, as local businesses adapted and the community pulled together to realise a more sustainable future. However, as a second wave of restrictions threatens, the town has to dig deep to find the resilience they need to ensure their future. Can they re-invent their local economy to survive and thrive beyond Covid?’

View here (The Guardian, Nov 2, 2020)

Addressing Malaysia’s nutrition crisis post Covid-19: Time for nutrition-focused social protection

• With stunting and wasting at 21.8 and 9.7% respectively in 2019, Malaysia was experiencing a malnutrition crisis even prior to COVID-19.
• The COVID-19 pandemic has directly resulted in a severe economic crisis that will exacerbate food and nutrition insecurity.
• People who are already exposed to critical food and dietary deprivations before COVID-19 are most vulnerable to food insecurity.
• Food and nutrition insecurity are linked to malnutrition, where children in households with food insecurity were more likely to be malnourished.
• Beyond the consequences for individuals and families, food and nutrition insecurity has been linked to long-term economic effects such as higher health care expenditures, lower educational achievement, lost productivity, lower earnings in adulthood and increased risk of poverty later in life.
• Strengthening child-sensitive and nutrition-focused social protection is essential to reducing vulnerability, building resilience, and mitigating the impacts of COVID-19 crisis and should be a top policy priority

Download PDF here (Unicef, Nov 2020)